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By Hugo Medina M.

Dado que la producción de carbón en el Perú es menor frente a la demanda de petróleo, es necesario plantear una planificación de su estudio y sus posibilidades de desarrollo minero. En este sentido, el presente texto revisa las áreas prospectivas de carbón, reservas y su potencial como mineral con la finalidad de incentivar la reconversión industrial y las inversiones del mineral. Asimismo, señala los factores que afectan el desarrollo minero como el potencial carbonífero no tangibilizado a reservas, superposición, acaparamiento, prioritización y áreas reducidas; asistencia tecnológica y técnica y financiamiento. Finalmente, entre las alternativas de solución está el plan exploratorio nacional, operación minera, apoyo técnico, política de precios, madera, costo del transporte, capacitación e investigación, centrales hidrometalúrgicos, plantas de lavado de carbón y una ley de promoción carbonífera.

Aug 26, 1988

By José Vela E.

El almacenamiento de minerales en canchas para su lixiviación con líquidos no corrosivos, permite que estos no sufran pérdidas por filtraciones en terrenos de formación permeable. Por tal motivo, el presente texto describe la construcción de revestimientos de geomembranas impermeables que garanticen la retención de los residuos líquidos o sólidos en el proceso de lixiviación de minerales. Esta tecnología del revestimiento con geomembrana impermeable depende de factores como: la corroción del líquido, la oportunidad de su utlización, el tipo de terreno donde se deposita la membrana y la inversión económica esté disponible. Entre las más empleadas están: el revestimiento con geomembranas de asfalto, pre-fabricados, membranas de polivinilo y polieteleno.

Aug 26, 1988

By Edward Medina Bárcena

Actualmente la minera Atacocha explota minerales polimetálicos a través de dos tipos de relleno: hidraúlico y triturado. Sin embargo, el relleno de estas operaciones de minado se ha modificado, empleándose un nuevo sistema de operaciones mecanizadas. En ese sentido,el objeto del presente trabajo es incrementar la productividad, reducir los costos de relleno, mejorar las condiciones de vida y aumentar la vida económica de los scooptrams a través del sistema de relleno en la operaciones mineras, donde es necesario el traslado de arenas en las colas de las concentradoras ubicadas en Chicrin, zona alta del yacimiento.

Aug 26, 1988

By Rolando Luna B

El presente texto señala las áreas operables y marginales de cada veta trabajada dentro de la mina a través de la limitación rentable y marginal durante y para la operación de la mina. Para ello, se definen algunos conceptos del ámbito minero y se analiza la aplicación de una metodología más adecuada para la operación minera. En esta perspectiva, se busca encontrar áreas adecuadas en cada veta de explotación, cuyo valor de mineral se ubique por encima de tres niveles e involucre elementos de costos diferentes en la operación y administración de una mina. Una vez determinados los costos, se realiza la evaluación práctica de la veta mineral y se define cuáles son las zonas trabajables y no trabajables en función a los precios de los metales, costos geológicos, operativo y las proyecciones futuras de ambos.

Aug 26, 1988

By Carlos Santa Cruz

El presente trabajo refiere los fundamentos teóricos de algunas técnicas de conservación de energía eléctrica dentro de una operación minera como aquellas de control de demanda eléctrica, corrección del factor potencia, utilización de motores de alta eficiencia y control de la iluminación, a fin de enfatizar los beneficios económicos que se puedan obtener de su implementación.

Aug 26, 1988

By H. García

El yacimiento minero de Yauricocha cuenta con un área de exploraciones donde se ha encontrado material de afloramiento con terrones de oro y concentraciones de plata. Con la finalidad de seleccionar una alternativa que beneficie el tratamiento de estos minerales, se inició un programa experimental que evalúa el proceso de lixiviación en pilas a nivel piloto. En este sentido, el presente texto analiza la correlación de parámetros existente entre las diferentes escalas de experimentación que van desde el nivel de laboratorio hasta el pilotaje, a fin de plantear formulaciones matemáticas que faciliten el escalamiento de data y racionalizen mejor el proceso de lixiviación en pilas.

Aug 26, 1988

By Olivari O. Jorge

La explotación del yacimiento aurífero de San Antonio de Poto se realiza a través del uso de equipos pesados en el movimiento de tierra y plantas portátiles y gravimétricas en la concentración, así como los canales de refinería y petróleo. En este sentido, el presente trabajo señala los métodos de minado utilizados en la explotación de la mina San Antonio como son el método artesanal, semi-mecanizado y mecanizado. Para la remoción del mineral de cada método de minado, se utiliza la perforación y voladura. En cuanto a la evacuación del mineral grueso de los métodos de minado semi-mecanizado y mecanizado, se utiliza la locomotora con vagón. Finalmente, el empleo e equipos pesados y plantas móviles establece la necesidad de optimizar el empleo para justificar su inversión.

Aug 26, 1988

By Segundo Bejarano R

El presente trabajo describe las experiencias adquiridas en perforación y voladura en la mina Calera, perteneciente a la Compañía de Minas Orcopampa, a fin de a evaluar sus operaciones de minado. La perforación se realiza a través del uso de dos brazos de los equipos Jumbo Tamroc Minimatic y Upper Drills, constituyendo una perforación mixta de taladros horizontales y verticales respectivamente. Asimismo, cada equipo tiene sus áreas de operaciones de acuerdo a las condiciones geoestructurales del terreno, mejorando la supervisión y control de la red de perforación, así como de los equipos.

Aug 26, 1988

By Jorge Rodríguez V

El presente trabajo plantea una alternativa al sector cuprífero en tanto ofrece tecnologías que representen un valor agregado de los productos que se obtienen y un valor de uso intensivo Para logar este resultado, la recuperación del cobre se realizaba a través de la vía hidrometalúrgica, donde se empleaba la reducción por contacto con chatarra de fierro. Sin embargo, los trabajos actuales utilizan los solventes para la producción de sales de sulfato de cobre, logrando operaciones de selectividad de iones y concentración de los mismos. En consecuencia, el texto es describir los principales aspectos de investigación (batch y contínuas) para la producción de oxisales de cobre a través de soluciones cosechas de lixiviación de minerales oxidados de cobre.

Aug 26, 1988

By Pedro Tumialán

Desde el siglo XIX el distrito minero de Hualgayoc ha sido objeto de estudio por el Banco minero y la Geological Survey de Estados Unidos, realizando explotaciones de minerales polimetálicos. Posteriormente se desarrollaron explotaciones de oro en los óxidos de los 16 mantos de del Compañía Minera Los Mantos, ubicada en Cajamarca. En este sentido, el presente texto describe el proceso de explotación de oro en el yacimiento de Hualcayoc, cuya mineralización de la plata y oro en los mantos, registra un bajo costo de operación a través del proceso de lixiviación realizado en las rumas. Asimismo, los mantos presentan una concentración residual del oro en los óxidos que duplica la ley original, disuelven parte de la plata, el cobre y el zinc y están ligados a exhalaciones volcánicas continentales en el Apitiano y marinas en el Albiano.

Aug 26, 1988

By Oscar Perales P

Dada la necesidad de adquirir azufre puro para abastecer el consumo doméstico, se plantea el beneficio de los minerales portadores de azufre y caliches, provenientes de los yacimientos ubicados en el departamento deTacna. En este sentido, el presente texto refiere la etapa de beneficio en la obtención del no metal por el proceso de fusión en hornos licuadores provistos de sistemas de calentamiento por resistencias eléctricas. Es decir, se busca aprovechar el bajo punto de fusión del azufre respecto al material estéril acompañante a través de la definición de los parámetros de granulometría y temperatura de fusión de la carga. De esta manera, se maximiza la recuperación y pureza del producto obtenido y se definen alternativas para minerales de características no beneficiables para el método propuesto.

Aug 26, 1988

By Jan M. Mutmansky, Christopher J. Rise

"One of the most serious long term health problems associated with underground,mining is Coal Workers Pneumoconiosis (CWI'), more commonly known as Black Lung Disease. It occurs in some coal workers, normally after 15 or more years of exposure to coal mine dust, and leads to a variety of respiratory problems. Two types of pneumoconiosis are recognized simple CWP, which has been estimated to affect 6.9 percent of miners and is a condition that does not impair the miner's ability to work nor reduce life expectancy; and a more severe form of black lung (called progressive massive fibrosis) that occurs in about one percent of the cases and results in severe lung damage.Although the relationship between coal dust and CWP has long been recognized, detailed knowledge of the relationship is insufficient for setting up authoritative guidelines to reduce the health risks for those employed in dusty,underground environments. CWP is not only a health problem for workers that causes considerable distress, it is also a very expensive problem the total annual costs associated with CWP approach two billion dollars.As part of its efforts to combat CWP, the U.S. Bureau of Mines in 1983 established a Generic Mineral Technology Center to carry out basic research into all aspects of respirable coal dust:— control of dust generation — the behavior of dust in the mine — characterization of dust particles interaction of dust and lung— the relationships among dust generation and mobility and the mine environment, geology, and seam characteristics,Penn State, West Virginia University, the University of Minnesota, and the Massachusetts Institute of Technology are involved in this research, which is administered from the Department of Mineral Engineering at Penn State.Our work is one of the seven projects to be conducted at Penn Slate. We are concerned particularly with the characterization of dust and its relationships with the mine environment, and our main goal is to establish standard procedures for describing and measuring these variables.Coal DustCoal dust is a very complex material that varies greatly in chemical and mineralogical properties. Moreover, it is not the only constituent of respirable dust in the mine. When a coal seam is mined, it is inevitable that rock particles other than coal are included in the material. This rock comes from the mine roof, the floor, and the partings and inclusions within the coal scams. Since the roof and floor strata, the partings and inclusions are often stronger than the coal, mining them frequently causes more dust than mining the coal itself. One of the objectives of our research is to find the relationships between a specific coal's characteristics before it is mined and the respirable dust characteristics after it is mined. We are particularly interested in the size distribution of particles, the chemical properties, and the mineralogical properties."

Jun 1, 1988

By R. V. Ramani, R. Bhaskar

"The control of respirable dust in mines has been given paramount importance due to the health and safety implications associated with fine dust. The understanding of the temporal and spatial behavior of dust has been recognized as essential for increasing the efficiencies of the existing control techniques and for developing new control strategies. Mining-related studies in this area are, in general, limited. They are also mostly experimental. Some mathematical and computer analyses have been attempted. In this paper, first a review of the mathematical studies performed in the last three decades in this area is presented. Second, a mathematical model for analyzing dust flow in mines is proposed. The model takes into account a number of factors affecting dust transport. It incorporates varying dust generation source strengths and dispersion, deposition, and coagulation of dust in mine airways. Finally, application areas for the model are discussed. A computer program based on the mathematical model has been developed. The program will output the dust concentration in the mine atmosphere as a function of time and distance from the source. The amount of dust deposited on the sides, roof, and floor of the airway is also determined.IntroductionAn airborne dust cloud is a complex system containing particles of varied size, density, shape and state of aggregation. The behavior of the particles is dependent on a number of complex physical mechanisms, often opposing in nature. The net interaction results in the ambient concentration. This size dependent behavior of particles contrasts with that of gases, an area quite widely studied.The term aerosol is used to describe clouds of microscopic and submicroscopic particles in air such as chemical smoke or particulate matter released from smoke stacks. An aerosol system can be regarded as an arbitrary element of volume filled with gas and suspended particles of possible highly variable physiochemical nature. The parameters that are used to describe an aerosol system include concentration, mass average velocity and particle mass and radius. In characterizing such systems, several assumptions are made. Among these is the assumption that particles are smooth, inert and rigid spheres. Again, for example, when the particles are in transport, the possibility of collision exists. As a result of the collision, the particles may coalesce to form larger particles. The probability of sticking is considered a known quantity (lady, 1970). In this paper, the application of the principles used in aerosol systems is explored for the study of the transport and deposition of fine coal dust in underground mines."

Jun 1, 1988

By A. Wahab Khair, Nagendra P. Reddy

"This paper presents an analysis of preliminary tests on the effect of in-situ and operating parameters on fragmentation of coal using a specially designed unique automated rotary coal cutting simulator (ARCCS). In these tests coal blocks with an approximate dimension of 18 in. x 15 in. x 6 in. (45.7 cm x 38.l cm x 15.2 cm) were first. subjected to confining pressures, equivalent to in-situ conditions. Such. blocks were then cut by the cutting head of the ARCCS, thus simulating the action of the continuous miner in underground coal mining. During the tests under a particular set of in-situ and operating parameters a number of other parameters such as 1) penetration of bit into coal, 2) penetration resistance (thrust and cutting pressures), 3) rotating velocity of cutting head, and 4) acoustic emission activity in the coal block were monitored. After each cutting cycle the fractured surfaces were photographed and a velocity survey was conducted by using a sonic technique. At the end of each experiment the cutting paths of the bits in coal were photographed using an optical microscope with a camera attached to it. Furthermore, the coal fragments were collected in bags using a vacuum cleaner. These fragments were then sieved for size distribution analysis. The results of the preliminary tests indicated that underground coal cutting can be simulated in the laboratory and the effects of the important parameters, i.e. operating and in-situ parameters, can be studied successfully. INTRODUCTIONThe continuous-mining machines which were introduced in the 1950's now account for more than half the production of coal from underground mines. Unfortunately, these continuous miners, which were designed for increased productivity, have also increased the concentration of respirable dust in mines. As a result, the Federal Coal Mine Health and Safety Act of 1969 was enacted to enforce on the coal operators that the airborne respirable dust not exceed 2 mg/m3, and was intended to reduce the incidence of coal workers pneumoconiosis. This plus the other aspects of the legislation and the subsequent monitoring and enforcement by MSHA made it very imperative that the coal operators provide a relatively healthier and safer working environment for the coal miners. Since 1970, the Federal government has paid over 11.7 billion dollars to more than 470,000 miners with coal workers pneumoconiosis and their survivors (1). These regulations, coupled with the assessment of the continuing burden on miners, the mining industry and taxpayers appear to have provided an impetus for the mining .community towards comprehending the different parameters that influence dust generation and entrainment."

Jun 1, 1988

By A. Wahab Khair

"Geologic materials emit transient noises when stressed /1/. The rate and pattern of these transient noises or acoustic emissions (A.E. hereafter) depend on the stages of deformation of the material /2/. It has been demonstrated that rock/coal fracture processes under stress consist of three distinctive stages--crack initiation, propagation and ultimate fracture--and that coalescence of numerous cracks leads to ultimate failure rather than the propagation of a single crack /2,3/. This paper presents an analysis of fracture formation in rock/coal specimens subjected to straight wedge indentors using A.E. technique.The effect of specimen geometry, wedge indentor angle, confining pressure, and material anisotropy on fracture type (tension, extension, and shear crack), fracture length, and fracture intensity were studied. Two types of material mainly Berea sandstone and Coal Berg No. 2 coal were used in this study. Prior to the experiment the mechanical properties of both sandstone and coal were determined using rectangular specimen (Figures 1 a) in standard compression tests and are given in Table 1. In this study cylindrical and rectangular specimens were first prepared to proper dimensions of 2 in. x 1.5 in. and 3 in. x 1.5 in. x 1.5 in. (5.08 cm x 3.81 cm and 7.62 cm x 3.81 cm x 3.81 cm), respectively and then instrumented with SR-4 strain gages as shown in Figure 1. The instrumented specimens were then tested under four distinct load boundary conditions as illustrated in Figure 2. During a typical experiment the instrumented specimen was placed in a specially designed loading jig (Figure 3) where a predetermined lateral pressure was applied mechanically to the specimen by adjusting the inner plate of the confining chamber via screw while monitoring strains in the specimen. Using rock/coal elastic constants and measured strains, a predeter¬mined lateral pressure was applied to the specimen. Then a vertical load was applied by the straight edge of a wedge indentor attached to the upper platen of the universal loading machine via ball and socket arrangement (Figure 4). The arrangement allowed uniform application of load in a straight line manner on the surface of the specimen. During the test a number of parameters namely strains, load and A.E. rates were recorded (Figures 5a-b)."

Jun 1, 1988

By W. E. Wallace, V. Castranova, P. Hathaway, F. H. Y. Green, E. D. Recad, V. Vallyathan, M. J. Keane

Inhaled particle contact with pulmonary surfactant in the hypophase lining pulmonary alveoli was modeled in vitro by exposing two respirable sized dusts, kaolin and silica quartz, to lecithin, a major component of pulmonary surfactant, emulsified in physiologic saline. Lecithin adsorbs to the dusts upon incubation at 37º C and suppresses their cytotoxicity as measured by pulmonary macrophage and erythrocyte assays, suggesting that pulmonary surfactant provides a defense system against prompt cell membrane lysis by inhaled dusts. Subsequent pulmonary macrophage phagocytosis and lysosomal enzyme digestion of the coated dusts was modeled in vitro by incubation with phospholipase A2 for one hour. With increasing lipase activity, silica hemolytic potential was restored to native silica levels. Kaolin was retoxified to levels far in excess of native kaolin hemolytic potential. Elution, thin layer chromatography and phosphate assay of treated dusts indicate most lecithin on silica is digested to lysolecithin and desorbed, silica retoxification being due to surface and adherent lysolecithin effects. Most lecithin on kaolin is not digested in this same time; that which is results in adherent lysolecithin which is responsible for the kaolin retoxification. Digestion with phospholipases A2 and C together produces only weakly retoxified kaolin. Results suggest that surface adsorption properties which control the adherence of prophylactic surfactant distinguish the pathogenic potentials of quartz, kaolin and mixed dust.

Jun 1, 1988

By A. Wahab Khair, Richard D. Begley

"This paper presents results of destructive tests performed on rectangular coal specimen under the influence of two vertical and simultaneous wedge indentation forces. Several wedge designs and spacings were utilized in compression tests. The objective of these experiments was to qualitatively monitor the effect of different wedge designs and spacings on the stress distribution within the coal specimen.Coal samples from the Waynesburg coal seam were cut and trimmed to cubical dimensions of approximately 5 X 10 X 20 cm. These specimen were subjected to parallel compressive forces through two vertically applied wedge indentors. Loading was achieved with a hydraulic hand pump in order to facilitate interferogram construction. The load increments were limited due to the sensitivity of the holographic interferometric technique (holometry) in measuring small displacements; therefore, interferograms were taken only during similar increments in order to allow for a qualitative comparison between different wedge design and spacings. In some cases, interferograms were taken immediately before and after failure of the specimen.Introduction Failure Modes Three distinct modes of failure occur when geologic materials are subjected to wedge indentation forces. As shown in Figure 1, a crushed zone is located immediately adjacent to the indentor while chipping can occur if the fractures initiated in the crushed zone extend upwards to the free surface.. The third failure mode is a zone of intricate frac¬tures located between the crushed zone and the chipping zone. Several experiments have been conducted over the years to better understand crater formation and stress distribution within geologic materials under the influence of an indentor. Generally speaking, crack initiation and propogation observed in these experi¬ments correlate fairly well with wedge indentation theory; however, the nature of the .fractures is greatly influenced by different material properties such as grain size and cleavage planes. In other words, a wide range of behavior has been found in different rocks subjected to wedge penetration. For example, it has been observed that some rocks are merely crushed and indented while others are more prone to cracking and chip formation. Therefore, the development or nondevelopment of chips depends mostly on wedge geometry, rock type and depth of penetration. This work is part of the study associated with opti¬mization of cutting parameters, which is best modeled by using brittle materials and subjecting them to rigid wedge penetration tests."

Jun 1, 1988

By A. Wahab Khair, W. M. Devilder

"This paper presents an analysis of fragment size distribution and characteristics of fracture surface in coal cutting using a rotary coal cutting simulator. Coal cutting by a drum type continuous miner was simulated in the laboratory. A series of tests along both the face and butt cleat direction of coal under different operating and in-situ conditions were performed. In each experiment the cut surface was photographed microscopically and the coal cuttings were collected and sized. Data were used to show how and to what extent various parameters effect size distribution of the coal cutting and how this correlates with the characteristics of the fracture surface. This study resulted in establishing a number of distinct correlations between the size distribution and fracture surface. These correlations were primarily based on the degree of interaction between adjacent bits and the amount of bit-coal interaction taking place on the cutting path. Some of the major results of this study are as follows:Zones of bit-coal interactions proved vital toward understanding the effect the conical bit has on the fragmentation process. This in turn led to the identification of areas which are responsible for the production of fines and generation of respirable dust.The various parameters employed in the coal cutting experiments which showed a strong effect on the coal fragment size distribution were: bit type, bit spacing, depth of cut, in-situ stresses, and cleat orientation. Bit angle and cutting head velocity exhibited the least effect and no correlation was established.From this study it is obvious that the key to achieving efficient coal fragmentation is to limit the degree of bit-coal interaction that takes place throughout the bit path while causing maximum interaction between adjacent bits. Accomplishing this not only increases the percentage of large fragments produced but limits the amount of secondary crushing that takes place in the bit path thus resulting in decreasing fines and consequently, the amount of respirable dust generated.Over 2,000 continuous mining machines (introduced in the 1950's) equipped with conical bits or point attach bits account for well over half of the United States' production from underground coal mines. Today, competition in the coal industry has increased, due mainly to coal market conditions and legal restrictions, thus placing an emphasis upon increasing production, efficiency and health/safety of the workers. Mine operators are always interested in finding the most efficient performance of continuous mining machinery to produce the largest amount of size of coal at the lowest cost. An increase of fine material sent to the cleaning plant can seriously overload the plant to the extent that plant efficiencies deteriorate significantly (1). Also, the difficulty and expense of cleaning very small particles often cannot be done economically and thus, thousands of tons of coal are sent to the refuse pile because of costly or ineffective cleaning facilities. It has been said, ""the efficient extraction of coal or rock implies breakage into a size range that contains a minimum quantity of very small sizes"" (2). All known fragmentation theories concur that more fragmentation requires more energy (3). So, the importance of reducing fines is already evident from an outlook upon efficiency.Now, let's consider another view point., duet generation."

Jun 1, 1988

By D. Hinton, M. McCawley, R. C. Lantz, F. Pisano, C. Stanley

"INTRODUCTION Aerosols (5 um have not been shown to be consistently generated and characterized in inhalation chambers. Particle deposition in the lungs however may occur with particles as large as 25 um(1). Therefore, in order to closely simulate the atmosphere of an underground coal mine where the distribution is bimodal, with modes at S and 15 um (2), particles much greater than <1 um must be characterized for uniform mixing and size distribution within these chambers. The Hazelton Animal Exposure Chamber has been chosen because it has been best characterized for smaller particles (<1 um) (3), and is the major type used by most inhalation toxicology institutes such as Lovelace Inhalation Toxicology Institute and Battelle Northwest Laboratory.BACKGROUNDPreviously published studies on the inhalation of solid aerosols have attempted to characterize the distrition of particles of <2 um in diameter. There are no published reports of extensive work characterizing either the size distribution of particles <1 um or the concentration throughout the exposure chamber (Table 1).Table 1 shows the variability and sizes of several aerosols <1 um in diameter used in five previous chamber studies.Discussion of Previous StudiesThe study done by Bauermash, Bryan, Dickinson, and Burke (4)stated two major concerns in the development of the 6.5 ft. diameter chamber. The first was that a quantity of animals could be exposed to the same concentration regardless of the location of the animal, and second was that the chamber could be easily cleaned and decontaminated. The solution to the first concern required a circular chamber with the contamination air entering the chamber somewhere along the central axis. The animals could then be changed during exposure time so that each animal was exposed throughout the total volume."

Jun 1, 1988

By W. E. Wallace, V. Robinson, M. F. Keane, V. Vallyathan

"An in vitro study of the biologic responses of surface-modified and native silica and kaolin was made to provide comparative information on the supression of cytotoxicity by pulmonary surfactant. The release of alveolar macrophage cytoplasmic enzyme, lactate dehydrogenase (IDH), and lysosomal enzymes B-N-acetylglocosaminidase (B-NAG) and B-ghucuronidase (B-GLUC) and sheep blood-cell hemolysis were moni¬tored as indicators of cell membrane damage and cytutoxicity. Surface modification of silica and kaolin with dipalmitoyl lecithin (UPI) resulted in complete abrogation of cytotoxicity of both minerals. These findings indicate that surface modification of minerals with different adsorption properties by pulmonary surfactant generally lessens their prompt adverse effects.INTRODUCTIONAcute and chronic silicosis are well-characterized clinical and pathologic entities resulting from the inhalation of crystalline silica (Morgan and Seaton, 1984). Kaolin, a layered aluminosilicate clay frequently mined and used in manufacturing, contains tetrahedral silica alternately layered with alumina octahedra. Kaolin is relatively .inert biologically, and distinctly greater pulmonary burdens are seen in patients with kaolinosis than are seen in patients with silicosis. Crystalline siliea (quartz) induces a significantly greater degree of fibrosis in exposed animals in vivo than does kaolin (Hamilton and Hardy, 1974; Parkes, 1982; Hunter, 1976; Sheers, 1964; Warraki and t-lerant, 1963; Lynch and Mciver, 1954; Lapenas et al., 1984).This difference in pulmonary disease associated with the two types of dust is not reflected by in vitro cytotoxicity as Jetermined by pulmonary macrophage bioassays or erythrocyte hemolysis. Cytotoxicity studies using crystalline silica and kaolin of similar size fractions show comparable bioassay response on a mass basis. These cellular bioassays, therefore, do not correlate with the relative in vivo pathogenicity of silicates."

Jun 1, 1988