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By L. I. Boshoff, S. Gracie

This paper discusses pilot and laboratory-scale metallurgical test work conducted on bulk samples from a low grade heavy mineral deposit and provides an overview of basic practical metallurgical techniques applied to ascertain the suitability of existing production plants to process material from this orebody. Previous investigations have shown this specific orebody to be more challenging in terms of mineral beneficiation as it has a high gangue mineral content. Test work was conducted on targeted stratigraphic units based on lithology and assay results to enable identification of the stratigraphic units portraying quality issues. Unit specific metallurgical pilot work has never been conducted on any of the RBM orebodies and is a new field currently being explored. During this investigation focus was placed on potential quality and yield issues for ilmenite product, with particular reference to CaO quality. A basic evaluation of zircon and rutile separability was also conducted. The test work was conducted using a comparative baseline methodology with metallurgical test work methods specifically aiming at mimicking the existing production plant as closely as possible. This enabled not only the likely metallurgical performance to be assessed but also indicated whether current plant design would be suitable to process the low grade ore types into products of acceptable quality at acceptable yields. The methods and findings discussed in this paper indicate that although there is considerable variation between different units, a blended feed can be successfully processed. With unit specific metallurgical data applied to the existing geological block model, expected yields and recoveries using current plant designs could be predicted.

Jan 1, 2007

By G. J. de Korte

Dense-medium beneficiation of fine (minus 0.5 mm) coal is not a new concept and has been used in South Africa previously. The dense-medium fine coal plant at Greenside Colliery operated for almost 18 years and, despite proving a difficult plant to operate, did succeed in producing a fine coal product with a low ash content of 7%. No other beneficiation process available could achieve this. Dense-medium beneficiation of fine coal was also used in other countries, of which the plants at Homer City in the USA and Curragh in Australia were the best known. The first application of dense-medium cleaning of fine coal was, however, at the Tertre plant in Belgium1. This plant was built in 1957. About nine years later, a second fine coal dense-medium plant was built at the Winterslag Mine, also in Belgium. According to reports, this plant operated satisfactorily for a period of some 17 years.

Jan 1, 2002

By A. W. F. Smith, P. B. Prangnell, D. N. Crowther, P. J. Apps

It is well known that the refinement of grain size in metals leads to a significant improvement in important mechanical properties. As part of a European collaborative project, processing schedules have been investigated aimed at producing a homogeneous ultra-fine ferrite and spheroidised carbide aggregate microstructure structure in high carbon (CMn) steels (0.6-1.2wt%C), via conventional 'warm' rolling and innovative Equal Channel Angular Extrusion (ECAE). Suitable deformation schedules were determined from dilatometry and thermo-mechanical Gleeble simulations. Evidence of an ultra-fine ferrite and carbide aggregate microstructure following 'warm' rolling is given. A significant improvement in tensile strength, particularly proof stress (0.2%) was also noted in comparison to material deformed at higher temperatures. Concurrent Equal Channel Angular Extrusion (ECAE) experiments investigated microstructural evolution with incremental strain. Extensive analysis was carried out using various techniques, including high resolution Electron Back Scattered Diffraction (EBSD). Evidence of ferrite grain refinement was noted in a eutectoid composition steel. A sub-micron ferrite structure was observed following high strains (E-3.33) and the mechanical properties exhibit a marked increase in tensile strength.

Jan 1, 2004

Jan 1, 1884

By K. Leutwyler

The key to realistic casing stress analysis in thermal recovery installations is accurate knowledge of the temperatures involved. Much information leading to prediction of heat losses from tubing string to wellbore has been published. This .same information permits calculation of casing temperature under certain conditions. This paper reviews the basis for most of the published work, the line source solution to the diflusivity equation and examines some of its application criteria in the light of unsteady-state conditions. An alternate finite differences method is presented for correlation, and experimental data pertaining to the heat transfer mechanism in the annulus is reported. In the light of the information presented in the paper, it appears that the assumption of a line source for the tubing-wellbore system is valid even for reasonably short periods of heat flow, .such as "steam soak" operations. The empirically modified equation presented earlier matches computer derived results of the finite differences approach lor periods as short as 50 hours. Previously predicted cas ing temperatures and the associated stress levels are thus verified based on these correlative computations and the reported experimental information. Fall out from the computer output resulting in some studies of the influence of insulating cement properties on casing temperature, and experimentally studied effects of nitrogen placed in the annulus at various pressures., are described. INTRODUCTION Generally speaking, predictions of average casing temperatures have been based on an idealized model involving a centralized tubing string at uniform constant temperature radiating energy towards the casing under steady-state conditions.'. ' Heat is transferred away from the casing to the formation by unsteady-state conduction across thermal barriers consisting of cement and the mud sheath. Heat balances written on the casing permit prediction of instantaneous casing temperatures. During early periods of injection, casing temperature varies appreciably as a function of time; however, for long injection times this variation decays as heat flow from the wellbore to the formation stabilizes, and it becomes virtually negligible as conditions surrounding the wellbore become quasi-steady-state (Fig. 1). Carslaw and Jaeger -escribe a solution to the diffusivity equation for a line source (Fig. 2). A constant supply of heat is introduced into the medium from the line placed into the origin of the x-y coordinate system and parallel to the z-axis. Heat spreads outward in the infinite cylindrical solid and the temperature increase on a line going through point (x, y) parallel to the z-axis at a distance r can be predicted by: The following criterion must be considered: the Carslaw and Jaeger equation is obtained on the basis of a large

Jan 1, 1967

By A. L. Mular

In order to simulate a grinding circuit, it is necessary to obtain valid mathematical models of the grinding mills and classifiers in the circuit. Several models of grinding mills Ova been proposed 1,2,3 and models of cyclone classifiers are available 4,5. Those models developed by Lynch et. al. 3,5 have been tested in the plant, so that some degree of reliability can be placed on them. Because of this, it is reasonable to assume that the Lynch models will apply for a given circuit, and then to test this assumption. Empirical modifications are made as necessary for a given situation. Usually, valid simulation models can be modified slightly to provide control models6,7. The purpose of this paper is to describe the results of an approach taken by Mular8 to obtain the Lynch models of parallel cyclone classifiers being used in the A-circuit of the new Strathcona Mill***.This was one of the projects undertaken by the fourth year Metallurgical Engineering Class of 1969, Queen's University, Kingston, Ontario, Canada, as part of their process design course which cooperates closely with the Canadian metallurgical industry.

Jan 1, 1970

Agnico-Eagle Mines Ltd. comprises a Gold Division at Joutel, Quebec, and a Silver Division at Cobalt, Ontario. In 1979 the Silver Division milled 41,700 mt (46,000 st) of ore at a recovered grade of 139 g per mt (4.06 oz per st) for a production of 5,816 kg (187,000 oz) of silver. The 100 -year -old mining, camp of Cobalt has long been noted for its high-grade silver ores, and now seems to be on the threshold of being revived with several companies operating in the area. In 1979, the Gold Division milled at the rate of 27,200 mt per month (30,000 st) and processed 333,000 mt (367,000 st) at a grade of 6.58 g per mt (0.192 oz per st) with a mill recovery of 91.670 to produce 2,013 kg (64,700 oz) of gold. The average total cost per ton milled was $22.10 per mt ($20.05 per st) which was $3.66 per g ($1 13.90 per 0s). These figures make Agnico-Eagle one of the lowest cost producers in North America. Gold occurrence in the Joutel ore is fine-grained and contained within sulfide facies composed mainly of pyrite with minor pyrrhotite. Two underground mining methods are employed with long hole stoping accounting for about 75% of the ore mined and shrinkage stoping the remainder. Ore from underground is hoisted into a 545 mt (600 st) coarse ore bin from where it is conveyed to a 45 mt (50 st) surge bin ahead of the 10-51 Hydrocone crusher. Crushed ore is then screened to make a 13 mm (112 in.) product with the oversize being recrushed in a 7-60 Hydrocone. Mill feed is conveyed to two 900 mt (1,000 st) fine ore bins. The Hydrocones were installed as part of a new crushing plant in March of 1980 and have contributed substantially to an increase in mill capacity. Space has been left to install a third crusher in the future. The fine ore bins discharge to a 2.75 m by 3.66 m (9 ft by 12 ft) rod mill, followed by a 3. 7 m by 5.5 m (12 ft by 18 ft) ball mill in closed circuit with a Krebs 380 mm (15 in.) cyclone to produce a 7070 minus 37 micron (400 mesh) .flotation feed. This pulp is first treated in a 34 cu m (1, 200 cu ft) Maxwell flotation cell and then in an additional twelve 2.8 cu m (100 cu ft) cells. Combined flotation concentrates are reground to 9070 minus 37 microns (400 mesh) in a 1.8 m by 4.9 m (6 ft by 16 ft) ball mill in closed circuit with a single Krebs 254 mrn (10 in.) cyclone. Flotation tailings are sent to the tailings dam. Reground concentrates are then aerated with lime to a single Pachuca and thickened in a 16.75 m (55 ft) diameter thickener with the addition of diesel fuel to render any activated graphite inert to adsorption of

Jan 1, 1981

Jan 1, 1948

By Robert C. Speck

Floor heave or deformation of the mine floor into the mine opening is a problem which has plagued coal mines in this country and others. In mining areas where room and pillar mining is practiced, floor heave generally occurs when the stress applied to the floor material by a coal pillar exceeds the bearing capacity of the floor strata. When the floor strata beneath the coal pillar fail, the pillar moves downward and displaces the material under it. This material, in turn, moves outward and upward into the mine opening (Figure 1). As the underlying materials fail, the load supported by the coal pillar may be transferred to adjacent pillars. If these are marginally stable, they too may become overloaded and push into the floor. Thus, floor heave can spread through a large portion of the mine in a progressive manner. As the pillars push into the floor, differential movement and flexure of the roof strata may cause them to weaken and fail, resulting in subsidence of the ground surface above the mine. This paper describes the problem as it was manifested in the Zeigler Coal Company No. 5 and Murdock room and pillar coal mines near Murdock, Illinois, and reports the results of a U. S. Bureau of Mines- sponsored study conducted by the University of Missouri-Rolla. During the course of the study, floor heave in the two mines hindered the transportation of men, machines, and coal to and from the working mine-face, interrupted ventilation plans, drastically increased roadway maintenance costs, intensified safety and strata control problems, destroyed large pieces of equipment, and, several times, pre- vented access to otherwise minable coal resources. The ultimate objective of the study was to develop one or more simple procedures to allow detection of a potential floor heave problem during the exploration phase of mine design--before initiation of production mining.

Jan 1, 1981

By J. A. Jr. Church

I. EARLY FURNACES. . COPPER blast-furnace construction in America has long recognized a general standard in the rectangular water-jacketed shaft with separate forehearth. The details, however, and especially those relating to shaft dimensions, have had to meet a great variety of conditions, and show no uniformity whatever. Selecting a few of the present day Western plants, we find furnace lengths varying from 12.5 to 87 ft., widths at tuyere level from 42 to 84 in., and heights above tuyeres from 5 ft. 4 in. to 22 ft. 4 in. ; and comparing present designs with those of the past, we meet contrasts no less striking. Unlike its transverse section, the length of a furnace has come to depend rather on the size of unit desired than on the requirements of smelting ; and if the question of length be ignored, several of the various existing designs can be grouped together on the basis of a common transverse section. This section, having a width at tuyere level of 56 in. and a height above tuyeres of 18, ft., was developed at Great Falls, and the story of its development contains some interesting features. Ground was broken for the Great Falls works in the spring of 1891. About a year later, the concentrator was able to begin operation, followed within the next few months by the Brueckner, reverberatory, and converter departments, and in April, 1893, by the first blast fur-

Jan 7, 1913

Plant based on the New Jersey refluxing process was installed at the Cockle Creek Works of Sulphide Corporation Pty. Ltd. to refine portion of the zinc output from the Imperial Smelting furnace.Refining of impure zinc is effected by distillation in two stages in vertical columns comprising a series of superimposed silicon carbide trays designed such that ascending zinc vapours and descending liquid metal are in intimate contact. In the first stage, portion of the zinc and its cadmium content are distilled from impure feed metal, condensed, and while still molten, fed to the second column in which zinc is boiled under controlled refluxing conditions to remove the cadmium content.The resultant zinc has a purity in excess of 99·995 per cent zinc.The availability of refined zinc has made possible the production of a number of zinc alloys for marketing in addition to the basic grades of zinc.

Jan 1, 1970

By M I. Pownceby, N A. S Webster, R Pattel, N Ware

The decrease in quality of Australian iron ore, coupled with the demand for more efficient energy use, necessitates closer monitoring and optimisation of process conditions for iron ore sinter production. Sinter properties are correlated with the mineralogical content and traditionally, quality control has relied on methods such as Fe2+ determination, point counting via optical microscopy and automated electron beam techniques such as QEMSCAN; these can have a typical turnaround time of several days between sampling and reporting of results. As well, there is additional uncertainty around quantifying some of the complex mineralogical phases in sinter such as silico-ferrite of calcium and aluminium (SFCA) and SFCA-I, which are key phases influencing sinter quality. There is a clear need for the implementation of alternative analytical methodologies that offer a turnaround in hours or even minutes to provide information to accurately maintain production conditions.X-ray diffraction (XRD) is a technique widely used for the quantitative mineralogical phase analysis (QPA) of ores and processed materials in the iron ore industry. Partial least squares regression (PLSR) analysis methods have recently been suggested as an indicator of sinter Fe2+ content from powder XRD data without the need for rigorous and often time-consuming mineralogical analysis by the operator. In this study we provide results from the implementation of PLSR to predict the strength of iron ore sinter. Results are sourced from a well-constrained data set comprising strength properties (as quantified by a tumble index (TI)) from a series of compact laboratory test samples. Using this data set it was determined that PLSR has potential to be used as a method for calculation of sinter TI from powder XRD data and, therefore, process control.CITATION:Webster, N A S, Pownceby, M I, Ware, N and Pattel, R, 2017. Predicting iron ore sinter strength through X-ray diffraction analysis, in Proceedings Iron Ore 2017, pp 331–334 (The Australasian Institute of Mining and Metallurgy: Melbourne).

Jul 24, 2017

By J. C. Febles

HISTORY. THE use of iron for the precipitation of copper was known at least as early as the fifteenth century. Both Paracelsus and Basil Valentine refer to it in their writings, as early as 1500 A. D. It was used in Peru for this purpose prior to 1637, and at Rio Tinto, Spain, as early as the sixteenth century. The statement has been made repeatedly that in the early history of the mining industry at Butte, the practicability of this method of recovering copper from solution was overlooked, and that enormous quantities of copper-bearing water were allowed to go to waste, the copper in which might easily have been recovered at small cost; and .that this oversight on the part of the mine operators was due to ignorance of this method of recovering copper. As a matter of fact, very little copper-bearing mineral was encountered in the mines of Butte until a depth of 400 or 500 ft. bad been reached, and in many cases much greater depths were necessary to reach the copper-bearing zone. The water encountered in the upper levels (although in most cases quite highly mineralized) contained little or no copper, and it was only after considerable areas of copper-bearing ore' had been uncovered and developed that copper sulphate began to appear in the mine water in any considerable quantity. In fact, the first water that was observed to contain copper carried it in such small amounts as to be of little or no importance. It was only after years of underground work had opened extensive areas of stopes, drifts, and other underground workings, these being subsequently filled with waste, nearly all of which contained small copper values, which became oxidized by exposure to the air and were acted upon by the slowly percolating mineral water, that the recovery of copper from mine water became commercially important.

Jan 7, 1913

By R. A. Anderson, O. D. Sherby, J. E. Dorn

Solid solution alloying increases the plastic properties of aluminum at elevated temperatures by solid solution strengthening, by restraining recovery and recrystallization, and by a Cottrell effect. When binary aluminum alloys are strained and aged at 1940° to 300°K they develop a yield point. This is attributed to a migration of dislocations to solute atoms during aging. IN view of the ever expanding interest in applications of metals and alloys to high temperature service conditions, it becomes increasingly important to be cognizant of the effect of various metallurgical factors on the strength of alloys at elevated temperatures. One problem of wide interest, not only because of its engineering significance but also due to its fundamental scientific importance, is the elucidation of the effect of alloying elements on the plastic properties of homogeneous a solid solutions at elevated temperatures. It is indeed astonishing to note that in spite of its importance, and in spite of extensive random testing of alloys at elevated temperatures, no systematic investigation has been reported yet on the effect of alloying additions on the plastic properties of a solid solutions at elevated temperatures. This deficiency in our knowledge prompted the investigation described in this report. Rather extensive data are currently available on the effect of alloying elements on the plastic properties of a solid solutions at atmospheric and sub-atmospheric temperatures. Such data might be ex- trapolated to higher temperatures and reasonable guesses might be made regarding the influence of such factors as recovery and recrystallization in order to hazard a qualitative estimate of the effect of alloying elements on the plastic properties of a solid solutions at elevated temperatures. Such

Jan 1, 1952

By J. D. Sudbury, J. E. Landers, D. A. Shock

The external corrosion of casing is one of the most important problems facing the present day production man. A 1953 NACE report' estimated the annual cost of casing corrosion at $2,200,000 in 22 fields studied. The fields represented only 10 per cent of the wells in the United States. It was significant that 77 per cent of the failures reported were due to external corrosion. A variety of means for combatting the casing corrosion problem have been discussed in papers such as the NACE survey' mentioned previously. No attempt to revicw these will be made in this paper. Thc scope of this paper has been limited to a discussion of the following major items: (I) an instrument for studying external electrolytic corrosion; (2) use of this instrument to determine the quantity of protective current required to prevent corrosion of casing; and (3) problem of accelerated external corrosion of the oil string at the base of the surface string. ELECTROCHEMICAL MECHANISM OF CORROSION It IS gcncrally belleved that one major cause of external corrosion is the existence of electrolytic cells operating between various formation waters. A theoretical discussion of the role of earth potentials in casing corrosion has been presented by L. de Witte and F. J. Radd.2 A brief picture of the electrolytic corrosion action between two differcnt formations (A and B) is presented in Fig. I. This picture is a review to many but is given to insure clarity. In the anode area, oxidation takes place as iron ions go into solution in formation A as a product of corrosion. In the cathode area. reduction takes place and hydrogen atoms are formed at the boundary between the pipe and formation B. The flow of electrons. as indicated. is into the pipe at the anode or corroding area and out of the pipe into the formation at the cathode. In order to conform with regulations of this journal, the flow of a conventional current (I! is also indicated in this sketch. All subsequent references will be to this so-called conventional current flow and will be indicated by the symbol (I). As this action takes place the layer of hydrogen developed on the cathode offers a resistance to the flow of current in the cell. It is said (hat the cathode has been polarized. This polarizing film can be rcmoved by addition of a so-called dcpolarizing agent which reacts with and removes this hydrogen film. Such an agent must be present in ordcr for this corrosion reaction to go at a rate sufficient to cause a severe corrosion problem. The two common depolarizing agents are: (I) oxy-sen. which readily reacts with hydro gen to form water, and (2) certain bacteria which use atomic hydrogen as part of their life process. It is not difficult to explain the presence of these agents. Oxygen may be present in some very shallow formations. Sulfate reducing bacteria are found to exist in nearly any ground where mud pits might be dug. THE CASING POTENTIAl-PROFILE Instrumentation A sketch of the equipment* uscd in determining casing potential profiles is shown in Fig. 2. The tool is run in the hole using a hoist truck with a three-conductor cable. This tool must be run with tubing and rods out of the hole and should be run with the flow line disconnected. By proper choice of electrode size it can be run in any size casing. The electrodes must be run in an open hole or a hole filled with oil. Measurements cannot be made while immersed in water. The tungsten carbide-tipped knives serve as the electrical robes and arc spaced 25 ft apart. The potential difference along a 25-ft section of casing is measured with a potentinmeter to an accuracy of about 5 mv. Current flowing in the pipe can then

Jan 1, 1956

US 4,185,872-In the solution mining of uranium values from a subterranean uranium ore deposit, a lixiviant comprising sodium sulfate or other alkali metal sulfate and optionally minor proportions of an alkali metal carbonate or bicarbonate and an alkali metal hypochlorite is introduced into the ore to solubilize uranium therein. The pregnant lixiviant is recovered for processing. E.T. Habib, Jr., assigned to Mobil Oil Corp. Jan. 29, 1980. 5 pp (299-4). Filed- 8-18-78 (934,933).

Jan 1, 1982

By Nicolas Reynier

The separation of radionuclide during rare earth element (REE) production is an important requirement for developing the Canadian REE mining industry. Separation of actinides from REE is often a large concern in the rare earth industry because of the need to manage the radioactive nuclides. A patented process developed for actinides extraction from radioactive wastes was applied to REE ore. Objectives were to optimize the process for REE leaching from ore, and separate radioactive impurities from sulphuric and nitric liquor by ion exchange (IX). Ore leaching was optimized using a surface response plan to ensure statistical significance. In optimized conditions, solubilization yields ranged from 90–95% for Th, 60–75% for U, 48–55% for LREE, and 59–75% for HREE in sulphuric and nitric media. Both media were compared for radionuclide removal from rich REE-bearing mineral liquor by IX. Actinides separation ranged from 92–97% for Th and 69–96% for U in sulphuric and nitric media.

By D. I. Phillips, P. J. Bethell

This paper focuses on the -1/2 mm cleaning at Elk Run Coal. The original circuitry incorporated desliming cyclones. Problems with slimes entrainment in the cyclone underflow (froth cell feed) resulted in poor froth cell selectivity. Laboratory test work led to the installation of high frequency desliming screens. Consequently, great improvement in cell performance was brought about by enhanced desliming with the ability to use split flotation. The modifications resulted in significant improvement in total plant performance and overall yield while maintaining clean coal quality.

Jan 1, 1987

By Sean Gallagher, William S. Marras, Alan S. Litsky, Velimir Matkovic, Deborah Burr, John Landoll

Study Design. Survival analysis techniques were used to compare the fatigue failure responses of elderly motion segments to a middle-aged sample. Objectives. To compare fatigue life of a middle-aged sample of lumbosacral motion segments to a previously tested elderly cohort. An additional objective was to evaluate the influence of bone mineral content on cycles to failure. Summary of Background Data. A previous investiga¬tion evaluated fatigue failure responses of 36 elderly lumbosacral motion segments (average age, 81 ± 8 years) subjected to spinal loads estimated when lifting a 9-kg load in 3 torso flexion angles (0°, 22.5°, and 45°). Results demonstrated rapid fatigue failure with increased torso flexion; however, a key limitation of this study was the old age of the specimens. Methods. Each lumbosacral spine was dissected into 3 motion segments (L1-L2, L3-L4, and L5-S1). Motion segments within each spine were randomly assigned to a spinal loading condition corresponding to lifting 9 kg in 3 torso flexion angles (0°, 22.5°, or 45°). Motion segments were statically loaded and allowed to creep for 15 minutes, then cyclically loaded at 0.33 Hz. Fatigue life was taken as the number of cycles to failure (10 mm displacement after creep loading). Results. Compared with the older sample of spines, the middle-aged sample exhibited increased fatigue life (cycles to failure) in all the torso flexion conditions. Increased fatigue life of the middle-aged specimens was associated with the increased bone mineral content (BMC) in younger motion segments (mean ± SD, 30.7 11.1 g per motion segment vs. 27.8 ± 9.4 g). Increasing bone mineral content had a protective influence with each additional gram increasing survival times by approximately 12%. Conclusion. Younger motion segments survive considerably longer when exposed to similar spine loading conditions that simulate repetitive lifting in neutral and flexed torso postures, primarily associated with the increased bone mineral content possessed by younger motion segments. Cycles to failure of young specimens at 22.5° flexion were similar to that of older specimens at 0° flexion, and survivorship of young specimens at 45° flexion was similar to the older cohort at 22.5°. Key words: biomechanics, low back disorders, fatigue failure, age, motion segments, vertebral endplate fractures, torso flexion, lifting, bone mass. Low back disorders (LBDs) are a major cause of both short- and long-term occupational disability in the United States, and it is clear that workers in certain occupations are more susceptible to LBD.2-5 Specifically, epidemiologic studies have shown that jobs involving heavy physical demands such as construction,2,3 mining,2,4 and farming,5 engender increased risk of back pain. These occupations are thought to experience high LBD rates as a result of their extreme postural and manual lifting demands. Studies have shown that jobs involving significant lifting 6-9 and jobs that involve frequent bending10-12 are associated with increased LBD risk. Workers in the mining industry, in particular, often have to lift heavy materials in restricted workspaces that compel torso flexion. An understanding of the impact of repeated loading of the spine in flexion on fatigue failure of spinal tissues is thus a critical issue for our research agency, which is concerned with reducing the pain and disability associated with LBD in the mining industry. It is well accepted that loads experienced by the spine during manual lifting tasks are sufficient to cause fractures in the endplates of lumbar vertebrae, particularly on repeated loading. 13-15 Endplate fractures may not be painful in and of themselves 16; however, evidence suggests that the process of internal disc disruption and disc degeneration may be initiated via endplate fractures. 16,17 It has been shown that endplate damage will alter the distribution of stress in the disc, resulting in buckling of the lamellas of the internal anulus.17 Once this process has been initiated, repeated spine loading will cause additional disruption of the anular fibers, resulting in formation of significant fissures or tears. 11-21 If these tears occur near or extend close to the outer portions of the anulus, a wound healing process is initiated, which involves infiltration of mast cells, macrophages, and re¬lease of cytokines and growth factors. 21 The presence of these infiltrates has been strongly linked to discogenic low back pain. 21,22 Indeed, for patients experiencing chronic low back pain, the prevalence of internal disc disruption is at least 39%,19 which represents the most

By R. Masse, J. Chameaud, J. Lafuma, R. Perraud

Estimating the risk of lung cancers for workers in uranium mines and defining the resulting dose equivalent limits have been made possible thanks to work carried out in two scientific fields : physics and epidemiology. Theoretical calculations on the basis of physical models for the former and epidemiological surveys on the mortality of uranium miners from lung cancer for the latter. However, even though considerable work has been done in these two areas, the results obtained still remain controversial on several points. The radioactive and physical instability of the aerosols present in the atmosphere of the mines and the biological complexity of the human lung which even the most sophisticated physical models can reproduce only very schematically have often proved to be insurmountable difficulties for physicists, explaining the uncertainties which subsist concerning the dose delivered to the various parts of the respiratory tract from the air breathed by miners during their work. Epidemiological investigations on the other hand, in spite of the high quality of the surveys carried out, remain open to criticism, essentially because of the very approximative estimation of the individual occupational exposure to radon daughters. This is due to the fact that uncertainties arise from the measurement of radon gas if the state of equilibrium with the daughters is not accurately known or, if the active deposit is measured, to the fact that these measurements are insufficient in number. The controversies and discrepancies which subsist with regard to the evaluation of the level of risk, and in particular for low doses, can thus be understood. In addition, epidemiological surveys cannot dissociate the carcinogenic action of radon from the synergistic or potentiating actions of tabacco and of other pollutants present in uranium mine air. Animal experiments have been largely taken into account for evaluating the toxicity of various radionuclides. This type of experiment is necessary when human data do not exist and has provided us with much information. For instance, the relative biological effectiveness of the various types of radiation, the metabolism of radionuclides and the mechanisms of cancer induction have been approached and satisfactorily resolved in this way. Concerning radon and its daughters, however, animal experiments have been used very little even though it seems apparent that they should complement epidemiological studies. For instance, whereas doubt can be cast on the data obtained from human epidemiology because of the uncertainty concerning the individual exposure of miners, those drawn from experiments are indisputable because in this case the dose is as perfectly known as the effect. In addition, the effects of radon can experimentally be appreciated separately whereas in the surveys, they cannot be dissociated from the effects of the other pollutants in the mine. Finally, there are no other means of dealing with the mechanisms of cancer induction. In order to gain any useful knowledge from this method however, the experimental model must necessarily present certain methodological guarantees and the effects seen in the animals must enable a comparison with those which appear in man. For this reason we will present here the animal model we have been using for 15 years, and will give the results obtained and compare them with human data and made a synthesis. Finally the conclusions which can be drawn will be discussed as well as their limitations with respect to the protection of uranium miners. I - MATERIAL AND METHODS Male SPF Sprague-Dawley rats were used. At the onset of the inhalations they were around 3 months old. Their small size makes it possible to expose a large number of animals at the same time. Their life-span is long enough to be able to follow the evolution of the cancers and to estimate the latency time. Finally, they present the advantage of having a very low rate of spontaneous lung cancers (SANDERS, 1979). I.1 - Three inhalation techniques were used. 1.1.1. – [Inhalation of radon decay products.] The inhalation apparatus has been described previously (CHAMEAUD et al. 1971). The first experiments utilized a room of a half cubic meter linked to a source made up of high grade uranium ore. Later on, a large installation was built with a 10 m3 inhalation chamber making it possible to expose up to 500 rats at one time at radon concentrations ranging from 100 to 10 000 WL for variable lengths of time (1 to 10 hours per day). These concentrations are higher than those to which the miners are generally exposed, but in order for the cumulated doses in man and in animal to be similar and delivered for the same fraction of their respective life-spans, the ratio of the concentrations should be approximately that of the life-spans. The concentrations of radon and its daughters during the experiments were carefully controlled thanks to multiple samplings of radon gas associated with measurements of radon decay products. I.1.2 – [ The dust inhalation chamber] has already been described : it is a dust-loading chamber where the dust content remains constant during the experiment and can hold over 20 - 30 animals (PERRAUD et al, 1970). I.1.3 – [Tobacco inhalations] take place in a smoke box

Jan 1, 1981