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Projections of coal reserves in Central Appalachia are essential for long-term planning in the region. Annual production is declining in states such as Virginia. And minable reserves for the Central Appalachian coalfield are challenged by difficult geological, mining and market conditions. To project coal mining longevity in this region, interviews with mining companies were conducted to determine and assess technical and economic factors that affect coal seam minability. This information was ap- plied to seam and coal reserve data developed by state and federal governments. The results were analyzed to determine the effects of various factors on the overall minable coal reserve base.

Jan 1, 1998

By Chris Campbell-Hicks

Methods used for assay of gold values in resource estimation, grade control or downstream processing are based almost entire­ly on Fire assay or Aqua Regia techniques. Both these tech­niques frequently produce spurious results. The mechanism of error is explained. Major decisions are made based on this often flawed data. This is what our operating budgets and projected cash flows are based on. Project economics demands metallur­gical accountability for performance predicted. Accountants and more astute members of the board are often not sympathetic to gold out-tum from plant production which is occasionally or consistently less than that predicted. Equally importantly, better than budgeted gold out-tum, resulting from under assaying will produce reconciliation or accounting problems (surplus cash flow) often denying correct timing of expansion or acquisition. Both these scenarios can be avoided if 'real world' extractable gold values are presented to financial managers at all stages. Such extractable gold results are now possible, and compared to fire assay and aqua regia, the assays are faster, cheaper, simpler and more accurate.

Jan 1, 1996

"One of the corporate values mentioned by many companies deals with respect for people. This paper discusses one aspect of this value, namely, the need for clarity of accountabilities and authorities. The job of the manager in achieving this goal is analyzed and the benefits of enhancing the manager-employee conversation outlined. IntroductionCorporate values usually refer to the standards of behaviour that the leaders of the organization expect of all employees, including themselves, in carrying out their duties. Terms such as integrity, respect for the individual, continuous improvement, continuous learning, teamwork, speed, and innovation are quite common. The company-specific values are typically developed by the top executives of the company, and then tested with a broader group of employees. Where the process works, employees have a good understanding of what behaviour is expected of them in doing their work, in making difficult decisions, and in interacting with others.Having spent considerable time in his career investigating and studying the management systems at over 50 of the most successful companies in Canada, the United States, Europe and Japan, the author has had the opportunity to visit organizations such as Hewlett-Packard, 3M, Xerox, Intel, Toyota, NEC, Komatsu, British Airways, and Eastman Chemical. These experiences, together with the work of many other researchers, including the work of Dr. Elliott Jacques, have helped significantly to form the thoughts expressed below.Rather than reviewing the creation of corporate values and their deployment through the organization, these remarks focus on issues over which managers and employees have some control. The value in which managers can have significant impact deals with people and the respect shown them in the workplace. The component of respect to be emphasized is to be clear about expectations or accountabilities for oneself and the people who report to you, and to ensure that personal authority matches those expectations."

Jan 1, 1999

By S. Afrouz, C. Keles, W. R. Reed, E. Sarver, T. Akinseye, A. Greth, L. Pan, F. Animah

The resurgence of severe lung disease among U.S. coal miners has not only highlighted the need for improved dust controls, but also the need for an improved understanding of dust characteristics and monitoring strategies [1]. Following up on prior work by the National Institute of Occupational Safety and Health (NIOSH) to demonstrate a novel wet dust collection system on a roof bolter [2], the current study explores the effect of that system on dust characteristics and uses interlaboratory comparisons to comment on analytical methods. Results indicate the wet system did not appreciably affect the composition or size of respirable dust in the vicinity of the operating roof bolter. However, the system does appear to have substantial benefits for the operator. NIOSH has already shown it can reduce the respirable dust mass concentration to which the operator is exposed during dustbox cleanout [2,3], which is a frequent maintenance activity that can re-aerosolize dust, and new results here indicate the silica and silicates content in this dust may also be reduced, thereby reducing the overall hazard. Moreover, regarding analytical methods, excellent correlation was demonstrated between measurements of quartz mass, taken first by NIOSH and then by a university laboratory, using direct-on-filter Fourier transform infrared (FTIR) analysis. This method is the basis for envisioned “end of shift” silica monitoring (quartz is the predominant form of crystalline silica in coal mines) [4]. For particle-level analysis by scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDX), there was more variability in results generated by two independent university laboratories.

Mar 1, 2024

By Rainer Antretter

While respirable crystalline silica (RCS) dust that arises in industrial production mostly emanates from point sources and can be well mitigated, the extraction of dust is much more difficult in underground construction, since locally generated dust spreads widely. Analysis of dust measurements shows that RCS values are difficult to predict, and effective dedusting systems are required to comply with permissible exposure limits (PEL) in breathed air. Dedusting systems are effective near the tunnel face, while dedusting of working areas away from the tunnel face is difficult or even impossible. In general, there is little temporal influence on the tunnelling work—except for drill and blast excavation—which makes it necessary to remove the deduster and ductwork from the face area. Concurrent work in the tunnel is affected by the backflowing air mass of ventilation and therefore the quality of this air mass must be considered. The use of personal protective equipment (PPE), e.g., dust filter masks, is considered the least-desirable safety measure available. However, for certain individual operations in the tunnelling process, the use of PPE cannot be avoided, especially if other technical mitigation measures are not possible. In tunnels with small cross sections for example, dedusting systems often cannot be accommodated and PPE must be used instead. This raises the question of whether the use of PPE can be avoided by designing appropriate excavation cross sections and allowing for the implementation of technically engineered mitigation measures. The paper highlights problems with dedusting measures and shows possible ways to achieve OSHA compliance.

Jun 13, 2021

By Emily Sarver, Cigdem Keles, Jonathan Gonzalez, Nishan Pokhrel, Lizeth Jaramillo

This paper presents a case study of respirable dust characterization in a thin-seam coal mine in southern West Virginia. Samples were collected in various locations within the mine and analyzed using scanning electron microscopy with energy-dispersive X-ray (SEM-EDX), thermogravimetric analysis (TGA), and Fourier transform-infrared (FT-IR) spectroscopy. The study found high non-carbonate mineral content, particularly aluminosilicates and silica, in the dust. The results indicate that fine aluminosilicate particles may interfere with SEM-EDX analysis, leading to an underestimation of coal content. The findings highlight the importance of using multiple analytical methods to accurately characterize respirable coal mine dust.

May 5, 2022

By E. F. Divers, R. A. Jankowski

In response to a request from the Mine Safety and Health Administration (MSHA), the US Bureau of Mines completed a respirable dust survey of 18 US coal preparation plants. Of these, three were essentially free of dust problems. Respirable dust exposure to workers in the remaining plants depended on the time spent in the dusty areas. In five of the plants surveyed, Bureau tests showed that in some areas worker exposures could exceed Federal dust limits in less than two hours. Cooperative studies were arranged with coal preparation plants using three different dust control techniques. These included a standard baghouse-type dust collector, two types of scrubbers, and an electrostatic precipitator. Results of these evaluations are presented. Various types of ventilation systems used during summer and winter conditions were also evaluated. Results showed that appropriate ventilation can provide a highly cost-effective method for controlling coal preparation plant dust.

Jan 1, 1987

By E. F. Divers

In response to a request from the Mine Safety and Health Administration, the Bureau of Mines has recently completed a respirable dust survey of 18 U.S. coal preparation plants. Of these, three were essentially free of dust problems. Respirable dust exposure of workers in the remaining plants depended on the time spent in the dusty areas. In five of the plants surveyed, Bureau tests showed that in some areas worker exposures could exceed Federal dust limits in less than 2 hours.

Jan 1, 1988

By R. Lindsay Mundell

During the past 12 years, use of longwall methods to mine coal in the United States has continually in- creased. Although these methods offer several advantages, health hazards often exist because of unique and difficult problems in the control of respirable dust. This paper discusses the results of respirable dust studies conducted on United States longwall mining operations in 1972and 1978. Current engineering control methods (ventilation, water application and use of machine cutting parameters) and administrative controls for minimizing employees' respirable dust exposures are discussed.

Jan 1, 1980

By R. Bhaskar

The advantages of recirculation of air in underground mines have been well recognized, and several papers have been written on the subject. Issues of concern to the various segments of the mining industry relate to the health and safety of workers, specifically, methane and respirable dust build-up in the air, high humidity and temperature at the work face. This paper presents a survey of various studies pertaining to recirculation as a prelude to the experimental and quantitative studies performed by the authors. Experiments were performed at a trona mine on the transportation and deposition of dust along the return airways, for three different velocities. Modeling studies were performed using dust deposition models. The model predicted data were compared with experimental data in order to lay the foundation for the development of advanced predictor models for recirculation in trona mines. Two models for dust deposition were analyzed. The model predicted data are in divergence from the experimental data, indicating the need to develop better models.

Jan 1, 1992

By M. L. Harris, J. Organiscak, S. Klima, I. E. Perera

"The National Institute for Occupational Safety and Health (NIOSH) Pittsburgh Mining Research Division (PMRD) conducted underground evaluations in an attempt to quantify respirable rock dust generation when using an untreated rock dust and a rock dust treated with an anti-caking additive. Using PDM 3600s and 3700s, these evaluations measured respirable rock dust levels arising from a flinger-type application of rock dust on rib and roof surfaces. Rock dust with a majority of the respirable component removed was also applied in NIOSH’s Bruceton Experimental Mine (BEM) using a bantam duster. The respirable dust measurements obtained downwind from both of these tests are presented and discussed. This testing did not measure miners’ exposure to respirable coal mine dust under acceptable mining practices, but indicates the need for effective continuous administrative controls to be exercised when rock dusting to minimize the measured amount of rock dust in the sampling device. INTRODUCTION Two factors have combined to renew concern regarding respirable dust measurements and compliance. This renewed recognition is due to two regulations that have modified operators’ rock dust schedules. First, the 80% incombustible requirement in intake entries has increased both on-section and outby-the-section rock dusting. Secondly, the recent respirable dust regulation change that has increased the number of respirable dust samples taken per sampling cycle. Previously, when only 5 samples were needed bi-monthly, rock dusting could be scheduled to not interfere with the respirable dust sampling schedule. The significant number of samples now required under new regulations combined with the need to maintain 80% total incombustible content in active mining areas require the schedules for respirable dust sampling and rock dusting to intermix. This raises concerns about the amount of rock dust that potentially is included in the sampler weight gain. Additionally, the respirable dust maximum was lowered from 2.0 mg/m3 to 1.5 mg/m3 (effective August 1, 2016) increasing concern that rock dust contamination may be an issue. Currently, the acceptable practice is to apply administrative controls such as keeping the miners upwind during rock dust application or to schedule rock dusting during a maintenance shift when the number of miners present is lower. NIOSH’s research examining the quality of rock dust has led to the development of hydrophobic rock dusts."

Jan 1, 2017

By M. L. Harris, J. Organiscak, S. Klima, I. E. Perera

"The Pittsburgh Mining Research Division of the U.S. National Institute for Occupational Safety and Health (NIOSH) conducted underground evaluations in an attempt to quantify respirable rock dust generation when using untreated rock dust and rock dust treated with an anticaking additive. Using personal dust monitors, these evaluations measured respirable rock dust levels arising from a flinger-type application of rock dust on rib and roof surfaces. Rock dust with a majority of the respirable component removed was also applied in NIOSH’s Bruceton Experimental Mine using a bantam duster. The respirable dust measurements obtained downwind from both of these tests are presented and discussed. This testing did not measure miners’ exposure to respirable coal mine dust under acceptable mining practices, but indicates the need for effective continuous administrative controls to be exercised when rock dusting to minimize the measured amount of rock dust in the sampling device IntroductionTwo recent regulations have modified operators’ rock dusting schedules in order to meet compliance standards. First, the 80 percent incombustible requirement in intake entries has increased both on-section and out by the- section rock dusting. Secondly, the recent change to the respirable dust regulation has increased the number of respirable dust samples taken per sampling cycle. Previously, when only five samples were needed bimonthly, rock dusting could be scheduled to not interfere with the respirable dust sampling schedule.The significant number of samples now required under new regulations, combined with the need to maintain 80 percent total incombustible content in active mining areas, require the schedules for respirable dust sampling and rock dusting to overlap. Although rock dust is considered a nuisance dust in relation to U.S. Mine Safety and Health Administration (MSHA) sampling, these overlapping schedules raise concerns about the amount of rock dust that potentially is included in the sample. Additionally, the respirable dust maximum was lowered from 2.0 mg/m3 to 1.5 mg/m3 effective Aug. 1, 2016, increasing concern that rock dust contamination may be an issue (MSHA, 2016). Currently, the acceptable practice is to apply administrative controls such as keeping the miners upwind during rock dust application, or to schedule rock dusting during a maintenance shift when the number of miners present is lower."

Jan 5, 2017

By Raja V. Ramani, Robert L. Frantz

"In response to the U.S. Bureau of Mines (USBM) Request for Proposal (RFP) for "" the establishment of a Generic Mineral Technology Center (GTC) in Respirable Dust,"" the Mining and Mineral Resources Research Institutes (MRIs) at The Pennsylvania State University (PSU) and West Virginia University (WVU) in association with participating MRIs at Massachusetts Institute of Technology (MIT), and the University of Minnesota (UMN) have prepared the comprehensive research program described herein. Michigan Technological University (MTU) joined the Center as an affiliate after its inception. This program was developed with recognition of the stated objective of the Federal Mine Safety and Health laws which is to "". . . permit each miner the opportunity to work underground during the period of his entire adult working life without incurring any disability from pneumoconiosis or any other occupation-related disease . . . .""Exposure to respirable contaminants in mine atmospheres has long posed a serious hazard to miners. The control of these hazards, some of which can have sudden and catastrophic consequences and some others, slow and long enduring, has been a major concern for labor, management and the government. This concern has manifested itself in four mechanisms of control -- (1) regulatory control through minimum standard setting by the passage of mine health and safety laws, (2) engineering control through design and operation of mines according to the best recommended practices, (3) interaction of dust and lung control through periodic physical examinations, wearing personal protection devices, etc., and (4) legal and social control through workman's compensation laws for occupation related health deterioration."

Aug 31, 1989

Use water-jet-assisted cut-ting technology to reduce the exposure of mi ne workers' to respirable dust. Approach Install water-jet-assist on mining machines and evaluate its impact on respirable dust. How It Works Water-jet-assisted cutting involves a mechanical cutting bit working in combination with a moderate pressure (generally up to 10,000 psi) water jet directed just in front of, or through, the bit tip. One of its advantages is reduced dust generation because the jet wets the face of the material being cut more efficiently than a conventional low-pressure water spray, thus capturing much of the dust before it ever becomes airborne. It also removes loose cuttings ahead of the bit before they are pulverized by the bit into respirable dust. Total water consumption is about the same as for conventional low pressure dust control water spray systems. However, there is some increase in power consumption because of the energy needed to provide the high pressure water.

Jan 1, 1987

By Wallace W. Roepke, Richard C. Olson

To adequately attack the longwall dust problem, the US Bureau of Mines funded a contract to define dust sources on a longwall mine face area. The study examined the shearer during sumping, cutting, and tramming, the conveyor, and the roof supports. Tests showed the shearer to be the major dust source. Introduction Long-term illnesses place a heavy burden on miners, the mining industry, and taxpayers. Black lung payments to more than 400,000 miners and their survivors exceeded $9 billion between 1970 and 1980. They are continuing at a rate of $1 billion per year. Recent MSHA data indicate more than 50% of the longwall faces are still out of compliance with the 2 mg/m3 (0.00007 oz per cu ft) respirable dust regulation. Allowable dust limits are often further reduced owing to the presence of silica dust. This substantially increases the problem's severity. Research in the 1970s showed that by modifying the mining method through changing drum-type mining machines from high rpm shallow cutting to slow rpm deep cutting, both specific dust and energy could be reduced (Black et al., 1978; Ludlow and Wilson, 1982; Roepke, Lindroth, and Myren, 1976). The coal mining industry is using more longwall equipment to economically obtain high productivity. This high production rate, however, makes it difficult for longwalls to meet the legal dust standard. Research is showing how both these concerns may be addressed at the mining face. Results reported here explain the relationship of various major elements of the longwall system to dust generation on the longwall face. This paper is based on work completed by Foster-Miller Associates Inc. Objectives were to differentiate dust sources on the longwall face and to quantify dust levels for various elements of the shearer drum. The work was accomplished in two phases. Jonathon Ludlow, project engineer for FMA, developed and performed the necessary testing (Ludlow and Marshall, 1983). Bradley, Hadden, and Weston (1983) have done evaluations on British coal mines that produced similar results to those reported here. They found causative rela¬tionships between haulage speed, production, depth cut, drum speed, and dust generation. They also found that roof support movement increased the dustiness, whereas this work indicated that support movement had only a minor effect on total dust exposure. Both of these results are valid when the variation of mining conditions is analyzed. British mines are deeper than US mines. Therefore, roof rocks and coal are more fragmented than in the shallower US mines. Other reasons for the dust differences include the weaker shales found in Britain and the variation of roof support equipment designs between the UK and the US. Four mines in this report had rock roofs and, thus, would be less dusty. The fifth longwall mine had a coal roof, but the large cross-sectional area and high air velocity minimized dust exposure. Mines and Equipment Five underground longwall mine sites were tested (Fig. 1). All were using double-ended ranging-drum shearers (derds) with some variations in equipment. The mines and equipment details are shown in Table 1. No modification of mining equipment or operating cycles was made during the first phase of testing. The mining process observed followed the normal mine operating procedures. Three GCA RAM-1 respirable dust monitors and two vortex anemometers with cycle notations on portable tape recorders were used in each face area. The start and end of each cycle segment were recorded. Dust monitors record the dust levels once every 10 seconds, thus providing a relatively continuous real time indication of change in

Jan 8, 1984

Reduce respirable dust in coal preparation plants. Approach Survey a representative sample of coal preparation plants to (1) determine the dust problem extent, and (2) evaluate practical dust control techniques. Coal Preparation Plant Survey Results Of the approximately 500 coal preparation plants in the United States, 18 plants in six States were randomly selected for survey. The raw hourly capacities ranged from 250 to 1,250 tons, plant construction dates ranged from 1037 to 1982, and usually 3 to 10 workers were required per shift. Respirable dust concentrations within the plants surveyed ranged from very good (less than 1 mg/m') to very poor (14 mg/m3). No relationship was found between dust concentration and age or capacity of the plant. Six of the plants had long-term respirable dust concentrations between 7 and 14 mg/m' in specific areas; six had concentrations between 2.2 and 6.2 mg/m'. Except fur ventilation, only 4 of the 18 plants used operating dust control devices with mixed effectiveness.

Jan 1, 1989

By D. L. Nussear, W. E. Wallace, N. Clark, M. Gautaum, G. Hong-Guang

"Results of a research effort directed towards identifying and measuring the genotoxic properties of respirable particulate matter involved in mining exposures, especially those which may synergistically affect genotoxic hazard, are presented. Particulate matter emissions from a direct injection diesel engine have been sampled and assayed to determine the genotoxic potential as a function of engine operating conditions. Diesel exhaust from a caterpillar 3304 diesel engine, representative of the ones found in underground mines, rated 100 hp at 2200 rpm is diluted in a multi-tube mini-dilution tunnel and the particulate matter is collected on 70 mm fluorocarbon coated glass fiber filters as well as on S"" x 10"" hi-volume filters. A six mode steady state duty cycle was used to relate engine operating conditions to the genotoxic potential. Results to-date on diesel exhaust have indicated that use of a primary component of pulmonary surfactant as a medium for collecting and applying respirable particulate material to cells for mutagenicity testing offers a true representation of in-vivo delivery of such respired aerosols to pulmonary cells and the genetic material within. Protocols have been developed to sample and assay the diesel soot and diesel soot/mineral dust complexes which would not compromise the surf ace and physical properties of the particulate material. Evidence has been gathered to show that diesel soot expresses mutagenic potential as dispersions in DPL in the Ames tests as well as sister chromatid exchange activity in the animal lung fibroblast ·derived V79 cell line. The results are comparable to the standard solvent extraction procedure. INTRODUCTIONDiesel engines are primarily associated with transportation; however, they are also very common in the work place. Of particular concern is the use of diesel engines in mining operations. Currently there are 1,950 diesel machines working in underground coal mines throughout the country. These units are used in 151 mines encompassing nine different states (MSHA, 1991). It is believed the use of diesel powered equipment has contributed to higher productivity in these mines. However, the exhaust from diesel engines operated in underground mines has been a subject of concern during the past decade because of its suspected relationship with health aspects. The particulate matter generated by the diesel engine is of particular concern."

Mar 1, 1992

By Cheryl Hill, Michael Keane, Pamela Mike, Raghoottma Pandurangi, William Wallace, Mohindar Seebra, Val Vallyathan

"Dipalmitoyl glycerophosphorylcholine (lecithin) dispersed in physiologic saline, a model of the primary component of pulmonary surfactant, is adsorbed by respirable quartz and aluminosilicate dusts. Dust cytotoxicity as measured by erythrocyte bemolysis and pulmonary macrophage enzyme release is suppressed by this adsorption. The degree of suppression of hemolytic potential versus specific adsorption of lecithin from dispersion in saline by respirable quartz and kaolin dusts are compared with dusts' BET specific surface areas to interpret the prophylactic effect of lecithin adsorption. Dust hemolytic potential versus medium pH is presented. Fourier transform infrared spectroscopy and photo-acoustic spectroscopy of lecithin on quartz and of lecithin on kaolin are presented and reviewed with results of studies of the time course of removal of lecithin adsorbed on mineral surfaces by digestion by phospholipase enzyme. Results are discussed in terms of a model of prompt neutralization of respired mineral dusts by pulmonary surfactant, and a gradual re-toxification by digestive processes acting on the adsorbed prophylactic surfactant coating following phagocytosis. INTRODUCTIONQuartz dust of respirable size is well known to cause fibrotic lung disease, but numerous questions persist in the understanding of the initiation and progression of this disease. Our approach concentrates on physical and chemical aspects of mineral dusts early-on in their interactions with living organisms, and we have chosen simplified models to investigate that interaction.In the alveolar ·spaces of the lung, tissue is coated with a surface-active material (pulmonary surfactant), which, among other functions, mechanically stabilizes the lung from collapse by reducing the surface tension of water in the alveolar sacs.1 This surfactant is also the material that is first contacted by a mineral particle that is transported to an alveolus and is impacted there. This surfactant material has been studied extensively. The primary components are known to be proteins (about 11 % in dog lavage fluid), and phospholipids (about 88%).2 Pbosphatidyl cholines constitute roughly 80% of the phospholipid fraction; about 70% of the phosphatidyl choline fraction is dipalmitoyl lecithin (DPL).2 Respirable aluminosilicate particles are capable of adsorbing dipalmitoyl lecithin from dispersion in physiologic saline, a model for a possible initial event occurring upon deposition of a particle in a pulmonary alveolus. As may be seen from Figure 1, the DPL molecule has several fixed charges at neutral pH; a positive charge on the trimethylamine (choline) moiety, and a negative charge on the phosphate group. Also evident are the two fatty acid residues of palmitic acid, which are bonded through ester likages to the glycerol segment of the molecule. The fatty acid moieties of phosphatidyl choline make the molecule inso1uble in aqueous solutions under normal conditions, but a colloidal unit of aggregated molecules called a micelle is usually formed spontaneously above a certain minimum concentration. Small micellar vesicles are generally formed in the laboratory by using ultrasonic agitation or by solvent evaporation methods."

Jan 1, 1990

By W. E. Wallace, P. S. Raghootama, M. S. Seehra, C. A. Hill, M. J. Keane, P. Mike

"Dipalmitoyl glycerophosphorylcholine (lecithin) dispersed in physiologic saline, a model of the primary component of pulmonary surfactant, is adsorbed by respirable quartz and aluminosilicate dusts. Dust cytotoxicity as measured by erythrocyte hemolysis and pulmonary macrophage enzyme release is suppressed by this adsorption. The degree of suppression of hemolytic potential versus specific adsorption of lecithin from dispersion in saline by respirable quartz, kaolin, and alumina dusts are compared with dusts' BET specific surface areas to interpret the prophylactic effect cf lecithin adsorption. Dust hemolytic potential versus media pH are presented. Fourier transform infrared spectroscopy and photoacoustic spectroscopy of lecithin on quartz and of lecithin on kaolin are presented and reviewed with results of studies of the time course of removal of lecithin adsorbed on mineral surfaces by digestion by phospholipase enzyme. Results are discussed in terms of a model of prompt neutralization of respired mineral dusts by pulmonary surfactant, and a gradual re-toxification by digestive processes acting on the adsorbed prophylactic surfactant coating following phagocytosis.Introduction Quarts dust of respirable size is well known to cause fibrotic lung disease, but numerous questions persist in the understanding of the initiation and' progression of this disease. Our approach concentrates on physical and chemical aspects of mineral dusts early-on in their interactions with living organisms, and we have chosen simplified models to investigate that interaction. In the alveolar spaces of the lung, tissue is coated with a surface-active material (pulmonary surfactant), which, sagas other functions, mechanically stabilises the lung from collapse by reducing the surface tension of water in the alveolar sacs.(1) This surfactant is also the material that is first contacted by a mineral particle that is transported to an alveolus and is impacted there. This surfactant material has been studied extensively. The primary components are known to be proteins (about 11% in dog lavage fluid). and phospholipids (about 88%).(2) Fhosphatidyl cholines constitute roughly 80% of the phospholipid fraction; about 70% of the phosphatidyl choline fraction is dipalaitoyl lecithin (DPL).(2) Respirable aluminosilicate particles are capable of adsorbing dipalmitoyl lecithin from dispersion in physiologic saline, a model for a possible initial event occuring upon deposition of a particle in a pulmonary alveolus.(3)"

Jan 1, 1988

By M. Townsend, E. L. Petsonk, B. Fedders, M. Niggemeyer, H. Abrons, E. Daniloff, J. Griffin, K. Kinsley

In certain populations, nonspecific airway hyperreactivity (HR) is associated with increased respiratory symptoms and decreased lung function. We analyzed standardized pulmonary symptom questionnaires and pre-shift spirometry with methacholine inhalation challenge (Chatham, M. et al, Chest 82: 15) on 228 control workers (C) with no known exposure to occupational hazards, and 200 underground bituminous coal miners (M). M and c were similar in age, height, sex, and smoking status. HR (defined as >15% fall in FEVI after up to 5 vital capacity breaths of 25mg% methacholine) was found in 25% of M and 28% of C (NS). M showed higher% predicted FEVI (%PFEV) than c (M 107%, C 104%*). 28% of current smokers showed HR versus 22% of never smokers (NS). Current smokers showed reduced %PFEV but were not different from lifelong non-smokers regarding prevalence of HR. Subjects with HR showed reduced %PFEV, (HR 101%, not HR 107%*) but M and c with HR showed similar reductions. M had more dyspnea and chronic cough than c*. Hyperreactivity was associated with increased symptoms in controls but not miners. In our study, the prevalence of HR in coal miners was similar to nonminers, and did not explain miners' respiratory symptoms. * P < 0.05

Jan 1, 1989