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By P. Wearden, K. Bryner, K. Vrana, V. Castranova, R. Dey, R. Reist, J. Blackford

"Summary: Fibroblast proliferation and enhancement of collagen synthesis are key steps in the development and progression of pulmonary fibrosis. The current investigation presents a fibroblast proliferation assay to detect the release of competence factors from pneumocytes. The specific objective of this study was to define cell culture conditions for fibroblasts that would allow selective detection of competence factors in test media. The results indicate the following: (a) fibroblasts should be cultured for 2 days in plasma-free medium rather than 2% plasma to assure complete quiescence; (b) 1% plasma was optimum for producing progression activity for the bioassay of a competence factor, while 0.5% plasma did not produce sufficient progression activity (yielding false negatives) and 2% plasma often contained significant competence activity (yielding false positives); and (c) fresh plasma should be used since the progression activity of plasma was adversely affected by freezing and thawing. Under these conditions, this bioassay can be employed with either rat or human lung fibroblasts to detect competence factors such as platelet-derived growth factor (PDGF), at levels as low as 25 ng/ml.Fibrotic lung disease, as a consequence of occupational exposure to silica dust. is characterized by the development of concentric hyalinized nodular lesions in the lung and the progressive loss of pulmonary diffusion capacity. Proliferation of pulmonary fibroblasts and enhanced synthesis of collagen by these pneumocytes have been shown to be key steps in the development of chronic silicosis ( 1 ). The regulation of lung fibroblast proliferation by cytokines released from alveolar macrophages may be an important pathogenetic mechanism in the development of the fibrotic process (2). Some cytokines stimulate fibroblast proliferation by activating specific phases of the cell cycle (3,4). In particular, platelet-derived growth factor (PDGF) promotes fibroblast proliferation by inducing the movement of quiescent (G0 ) cells into the G1 phase of the cell cycle (5). Insulin-like growth factor (IGF) and transforming growth factor-P (TGF-P). on the other hand, regulate the rate of transition of fibroblasts from G 1 into the S phase (5,6). These two classes of cytokines have been termed competence and progression factors, respectively. One approach used to examine the release of cytokines from macrophages is the fibroblast proliferation assay in which quiescent fibroblasts are exposed to culture supematants from macrophages exposed to various stimuli. In most of these assays, the supernatant contains fetal calf serum (FCS), which provides the competence factor(s) necessary to facilitate the proliferation of fibroblasts (7-9). Recently, a fibroblast proliferation assay using platelet-poor .plasma [lacking competence factor(s)] as a substitute for FCS bas been described (I 0, 11 ). In this assay, the release of a competence-inducing PDGF-like growth factor from rat and human macrophages can be distinguished from other cytokines that act as progression factors."

Mar 1, 1992

Confidence in the strength of the U.S. economic recovery was considerably enhanced by third quarter 1983 profits, which showed a 12.8-percent increase over those in the second quarter (table I). Although the increases were not as great as between the first and second quarter of 1983, profits have grown each quarter since fourth quarter 1982. Both total profits and profits per unit of output increased, which the Bureau of Economic Analysis (BEA) attributes to decreases in labor and nonlabor costs (per unit of output), as well as to moderate price increases. [ ] A number of durable goods sectors, however, continue to show profit declines, especially electrical and non-electrical machinery. Profits in the primary metal industry are still negative, but the economic picture of this industry is improving. Between the second and third quarters of 1983, capacity utilization increased somewhat in primary metal manufacturing and stone and earth mineral mining but did not change at all in metal mining. Capacity utilization in metal materials increased from 47.4 percent in the fourth quarter of 1982 to 64.2 percent in the third quarter of 1983 (table 2).

Jan 1, 1983

By Larry Gsellman

This report presents the results of a benefit/cost analysis of the Bureau of Mines' Coal Extraction RCD Program for the period FY 1977 through FY 1982. The analysis is an update of the analysis performed on the Coal Extraction R&D Program for EY 1975 - FY 1980 and presented in a MITRE report, MTR-7225, published in May 1975. Major changes included: new production scenarios and an update of R&D cost estimates.

Jan 1, 1977

By Wilbert J. Huff

The organization of the Explosives Division is indicated by the accompanying chart (fig. 1). As this has been discussed in a previous report3/, it will not be considered further in this report. The activities of the various units are outlined below. I. INFLAMMABILITY OF GASES AND VAPORS4/ Determination of the Explosion Hazards of Combustible Gases and Vapors Found in Mines and Industries The Explosives Division maintains, at the Pittsburgh Experiment Station, a laboratory specially equipped for the determination of the explosion hazards of combustible gases and vapors. Of particular importance, is the determination of the chemical composition within which explosions may occur and beyond which there is no danger of explosion, combustion or inflammation. These limits, known as the limits of inflammability, as determined by this and other laboratories, have been compiled in Bulletin 279 of this Bureau. The last revised edition (1931) of this bulletin has been exhausted. Since it was published, the Pittsburgh laboratory has determined the limits of about 40 combustibles and has ascertained more precisely ant accurately many previously published limits.

Jan 1, 1938

By L. M. Burman

The phase-boundary pressure required to maintain a natural hydrocarbon fluid in a single phase must be considered in planning the recovery of reservoir liquids by miscible-phase processes. The change in the phase-boundary pressure at reservoir temperature that results when a light component or a mixture of light components is added to a reservoir fluid is an especially important consideration. The cricondenbar pressure (maximum phase-boundary pressure) and the critical pressure are unique correlated pressures that have been utilized to calculate the change in phase-boundary pressure that may result when the composition of a reservoir liquid is altered by an additive. In this study one reservoir oil and three gas-condensate fluids are used as examples. Correlations pertaining to the critical and cricondenbar states in chapters 4 and 5 of Bureau of Mines Monograph 10 (3)5 were used to demonstrate how butane and lighter components added to these reservoir fluids affect their phase-boundary pressures.

Jan 1, 1962

By M. D. Aldridge

The results of a four-year research effort aimed at developing a practical and effective electronic system for monitoring safety conditions throughout a coal mine by displaying, at a central location, remotely measured parameters are described. This document presents the general philosophy of an experimental system in an operating coal mine. The conclusions drawn from this experience are presented and a typical design for a large coal mine is described.

Jan 1, 1974

By Harmon E. Keyes

Many organizations, including the Bureau of Mines, have made intensive studies of the application of leaching methods to relatively small low-grade disseminated deposits of copper ores, containing both oxide and sulphide minerals. One of the principal difficulties has been to obtain a solvent that could be made at a low cost and would effectively dissolve the copper minerals. Another drawback has been the high initial cost of a plant and the refined type of mechanism ordinarily required by standard practice for carrying out the leaching cycle. The Bureau of Mines has attempted to develop a cheap and efficient solvent that would especially meet the requirements of smaller plants. (See Bibliography.) It has been known that dilute ferric sulphate-sulphuric acid solution is an excellent solvent for most copper minerals, such as chalcocite, bornite, and oxidized forms, but not for chalcopyrite and certain silicates. A method of producing this solution from sulphurous products and waste liquors was developed by the bureau and tried successfully on a test-plant scale at the Southwest Experiment Station in cooperation with the department of mining and metallurgy, University of Arizona, Tucson, Ariz. However, this work did not involve the actual leaching of ores with the solutions thus produced or the cyclic use of the iron solutions in the regenerator cell. Except for certain laboratory tests, in which known impurities were added, no data were available to show the effect on regeneration if accumulations of impurities were built up in the leaching circuit.

Jan 1, 1930

By John D. Spencer

Projects aimed at achieving the least disturbance to the Nation's air, water, and land resources in the mining and utilization of coal continued to be a feature of the Bureau of Mines coal program. This reflects the current concern about damage inflicted on the environment by our growing and increasingly affluent society. Mine Health and Safety research, along with investigations related to all other aspects of coal extraction and use, also continued to be implemented and expanded.

Jan 1, 1970

By F. M. Jenkins

Longwall mining systems are used to mine approximately 50 pet of the world's total underground coal production. Single entries are the predominant method of longwall development in Europe and Asia, where mining conditions are more severe than those encountered in the United States. During the 1970's and early 1980's, the U.S. Bureau of Mines and the U.S. mining industry invested nearly $20 million in single-entry and related research. This report reviews the accomplishments of single-entry research in the United States and describes two U.S. single-entry field projects: the Sunnyside single-entry project in central Utah and the tunnel-boring project in northern West Virginia. Also discussed are a single-entry study conducted by North American Mining Consultants (NAMCO) and a single-entry design study conducted by Ketron, Inc. This Bureau report compares the resulting technology with European counterparts to further assess the utility and efficiency of U.S. systems.

Jan 1, 1990

By Jane Applegate

This report documents efforts to design, develop and test a training approach which would assist front-end loader operators in the acquisition of skills and awareness to reduce the probability of their involvement in accidents in the mining environment. The goal of this project was to prepare and use (on a trial basis) a training method and materials which would be generally applicable to any loader and surface mining operation while at the same time, be adjustable by mine personnel to meet the specific needs of each mining operation. This effort resulted in the Front-End Loader Training System, a structured, performance-based training approach with diverse instructional aids and classroom and on-machine training experiences. Validation of the System at a large western mine demonstrated the utility and flexibility of the training approach and materials.

Jan 1, 1983

By George Markon

The rapid growth and development of the Soviet coal industry rank the U. S. S. R. with the United States among the leading coal-producing countries. The coal resources of the Soviet Union are among the largest in the world, although coal development has been hindered by the disadvantageous location of the coal deposits with respect to the major consuming centers. Although coal production in the U. S. S. R. reached a record high, the total energy output of mineral fuels in 1957 was still far below that of the United States because a significant part of Soviet coal output was lignites or lower rank coals. Although the Soviet coal industry soon may exceed that of the United States in tons produced, the energy equivalent of Soviet output will be considerably less because of the inclusion of a high percentage of lower rank coals. Energy sources in the United States also involve large quantities of oil and natural gas, whereas coal supplies most primary energy in the Soviet Union.

Jan 1, 1959

By J. P. Walsted

Offgrade chromite concentrate, with a Cr-Fe ratio of 1.3 to 1.4 has been successfully smelted to produce useful ferroalloys. The Cr-Fe ratio is not improved, but the alloys can be used without a too drastic change in normal steel-mill practice. The ordinary high-carbon ferrochrome has been successfully produced by smelting under highly acid smelting conditions. An alloy containing 50 percent chromium was produced at a power consumption of 4,490 kw.-hr. per ton of alloy. Alloys containing 20 percent silicon were made by direct smelting chromite concentrate and silica.

Jan 1, 1956

By Jack L. Woodward

The evolution of surface mining equipment has resulted in larger, faster haulage units, loaders, etc., resulting in increased demands on steering technology. Careful analysis of these systems was warranted to determine if steering-related safety problems have been introduced. The objectives of this program were to: 1. Define the generic types of steering systems being used on mobile mining equipment used in surface mining operations. 2. Gather information on steering-related accidents in mining operations. 3. Assess the need for initiating government-sponsored research into steering system technology. A comprehensive literature survey was conducted concurrent with extensive contacts with mining operations, mining equipment manufacturers, steering system component manufacturers, and government agencies. A Technical Evaluation Group composed of representatives from the above organizations was formed to review the data gathered. It was concluded that the steering systems in use on surface mining equipment are reliable and do not present a safety problem. The Society of Automotive Engineers, Inc. is active in pre-paring voluntary consensus standards to assure that the minimum levels of performance are defined for industry.

Jan 1, 1979

By Edmund Newton

The Haile mine has been the outstanding gold-mining operation and the largest single producer of gold in the Appalachian region. Gold was discovered at the Haile in 1827, previous to the present operation, production has been nearly $4,500,000 (gold at $20.67 per ounce.) from somewhat over a million tons of ore, with an average extraction of about 70 percent. The Haile property, now operated by Haile Gold Mines, Inc., is in the southern part of Lancaster County, South Carolina, 3-1/2 miles northeast of the town of Kershaw and 55 miles north of Columbia, the State capital. (See fig. 1.) The corporation has a lease and purchase contract on 1,805 acres, covering the present productive area. In addition, it holds lease contracts on 1,500 acres additional adjacent to this area.

Jan 1, 1940

"IntroductionThe combined library facilities of the five universities in the Generic Technology Center for Respirable Dust, The Pennsylvania State University, West Virginia University, University of Minnesota, Massachusetts Institute of Technology, and Michigan Technological University, represent one of the most extensive and comprehensive collections of information on respirable dust research which is available in the United States. The Center encompasses two major medical schools, the Milton S. Hershey Medical Center at The Pennsylvania State University and .West Virginia University Hospital at West Virginia University, and includes national and international experts from such diverse disciplines as geology, geomechanics, mining engineering, mineral processing, electrical engineering, industrial engineering, mechanical engineering, material science, physics and several areas of medicine. In order to maximize achievements in research and facilitate early results application in the private industry, university, government and public sectors, a geographically dispersed Reference Center on Respirable Dust has been established at each of the affiliated universities. This network serves to encourage unity between the universities in the Center and coordination and communication with other entities who benefit from their research.Description of the Reference CenterIn this light, the goal of the Reference Center network is to identify at what location Information is available and to provide a means for others to access this information. It is especially necessary to have both ease of input and maximum retrieval capabilities available to all the research personnel in the Reference Center. At the same time, the service provided to the inquiring public must be complete and cost-effective. The Center's approach to realizing this goal incorporates advances in computerized and electronic searching of individual library holdings and the networking of major library and commercial search systems.The Reference Center uses the following means to achieve this goal. At each participating university, a hard copy collection ls maintained of the current respirable dust research in progress by that institution's personnel. Also, available. at each university ls a review of their past and present research on respirable dust. At each participating university a hard copy collection of annual status reports and of all publications produced by Center personnel for symposiums, national and international conferences ls maintained. A key word computer search capability ls available to participating universities. This computer search, by title, author and location, allows researchers to determine at which facility information is available, thus avoiding the tremendous expense and effort of housing all the information on respirable dust research under one roof. The Reference Center has access, through The Pennsylvania State University Libraries system and the libraries of other institutions, to a large number of data bases such as MEDLINE at the National Library of Medicine,"

Aug 31, 1989

By Frank E. Cash

Although during the past 10 years Alabama has attained an enviable position by its coal-mine accident experience and, like most of the other coal-mining States, has made progress in the safer operation of coal mines, there is still room for improvement, which can be realized only by still greater efforts on the part of employees and employers. From 1993, when accidents were first recorded by the Alabama State Mine Inspection Department, to 1934, inclusive, 3,451 men lost their lives in the production of 569,722,676 tons of coal. The primary purpose of this report is to bring to the attention of the mining industry in Alabama end elsewhere statistics of fatal accidents for 1931-34, with the hope that a study of the causes may lead to reduction of similar accidents in the future.

Jan 1, 1936

By W. R. Hardwick

This Information Circular describes the development of block-caving methods and practices by the Miami Copper Co. at the Miami mine in Gila County, Arizona. It is one of a series published by the Bureau of Mines on mining methods, practices, and costs in various mining districts of the United States. This report gives a history of the district and outlines early prospecting and exploration including methods of sampling and estimation of ore tonnage and value at the Miami mine. Early mining methods are described, particularly those that influenced developments in the caving method. Mine exploration, development, and operating methods for block caving are described with particular attention to those factors, physical, economic, engineering, and managerial that have improved efficiency in the mining operations over a long productive period. Extraction, ventilation, wage system, safety, water supply, power plant, and shop facilities are discussed. The last section gives a brief summary of such costs as are available for publication.

Jan 1, 1965

By W. R. Hardwick

This Information Circular describes the development of block-caving methods and practices by the Miami Copper Co. ar the Miami mine in Gila County, Arizona. It is one of a series published by the Bureau of Mines on mining methods, practices, and costs in various mining districts of the United States. This report gives a history of the district and outlines early prospecting and exploration including methods of sampling and estimation of ore tonnage and value at the Miami mine. Early mining methods are described, particularly those that influenced developments in the caving method. Mine exploration, development, and operating methods for block caving are described with particular attention to those factors, physical, economic, engineering, and managerial that have improved efficiency in the mining operations over a long productive period. Extraction, ventilation, wage system, safety, water supply, power plant, and shop facilities are discussed. The last section gives a brief summary of such costs as are available for publication.

Jan 1, 1965

By Walter I. Enderlin

To economically extract ore from great depths in the earth while sustaining an acceptable working environment will require the development of new technology and equipment, involving large capital expenditures. Moreover, careful analysis and advance planning will be required. But, the literature is lacking in data pertaining; to the thermal properties of various host rocks and to quantities of heat generated by various underground heat sources. This types, of data is required to forecast nine heat loads during advanced planning and design. This thesis sets forth a practical method for evaluating underground sources of heat in deep mines and provides an improved information base. Moreover, seven topics for further research are recommended. The heat sources considered are: wall-rock, ground water, adiabatic compression, equipment, service lines, blasting, metabolism, curing of cement, and oxidation of sulfides and timber. Seven deep metal mines with high production rates and high heat loads were visited to obtain data necessary to assess their thermal environments. Mine records were examined, wall-roc:, temperatures were measured and a survey of the mine ventilating air and mine drainage was performed. Also, the thermal conductivity of wet and dry specimens of the host rock were measured in the laboratory. Data analysis disclosed that rock heat and adiabatic compression account for stout 60 per cent of the mine heat load at depth. Equipment currently contributes approximately 20 per cent; however, to offset increasing costs with depth, increased mechanization is anticipated. The treat from ground water averages 19 per cent and the contribution from blasting, metabolism and cement is negligible. Also, approximately [0] per cent of the increase in the enthalpy of the ventilation air is in the form of latent heat. Moisture, however, did not significantly affect the thermal conductivity of the rock specimens measured in the laboratory. Also, from the data, it is evident that a negative correlation exists between the thermal conductivity of the host rocks and the per cent of the heat load derived from the wail-rock. Furthemore, steady state heat flow renditions may be assumed in airways where there has been no major changes in the ventilation system for a period of two years or more. Under these conditions, the author found it more convenient and reliable to compute heat influx using the steady state equation for heat flow into a cylinder, rather than Carrier's method for transient heat flow, which is so often used.

Jan 1, 1973

By K. M. Connor, O&apos

Variations in overburden geology must be considered in applying subsidence prediction methodologies developed by the U.S. Bureau of Mines (USBM). To characterize rock mass overlying high-extraction coal mines, the USBM utilizes a computer spreadsheet program and modified Rock Mass Rating (RMR) system. The spreadsheet calculates an RMR based on a bed's engineering properties determined from core logs and laboratory tests. An in situ deformation modulus and a bending stiffness are computed for each bed. Stiffness-versus-depth plots identify groups of beds with similar stiffness. Large variations in stiffness between adjacent beds are considered significant horizontal discontinuities where slip is likely. Time domain reflectometry (TDR) is used to verify this hypothesis by measuring shear displacement along such discontinuities. A model of the overburden is built by assuming that a near-surface laminated beam exists above a transition zone in which large plastic slip occurs along horizontal discontinuities. Increasingly thicker groups of beds are modeled to determine the most probable beam thickness based on a comparison with measured deflection profiles. The inverse of maximum beam deflection is an index parameter known as "bridging potential," a single value that incorporates both overburden geology and mine geometry.

Jan 1, 2010