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By Vincent Castronova, Jane Y. C. Ma, Joseph K. H. Ma, Chang-geng Mo, Carl J. Malanga

A group of bisbenzylisoquinoline (BBIQ) alkaloids has been shown to exhibit various degrees of effectiveness in preventing silicainduced fibrosis in animal models (1, 2). The capability of these drugs to interact with phosphatidycholine vesicles and rat alveolar macrophages was studied using fluorometric and equilibrium dialysis methods. The lipid binding affinity of these alkaloids was found to depend upon several structural factors including hydrophobic substitutions, the chiral configurations, and the double oxygen bridge-restricted conformation of the benzylisoquinoline moieties. Tetrandrine, which is highly effective in preventing fibrosis, showed strong binding to both lipid vesicles and alveolar macrophages. In contrast, curine and tubocurine, which have little or no effect on silicosis, exhibited only weak binding to lipid vesicles and almost no binding to cells. The moderate binding affinity of fangchinoline to vesicles and cells corresponded to a moderate effectiveness of the compound as an antifibrogenic agent. Methoxyadiantifoline, an alkaloid of unknown antifibrogenic potential, also exhibited high binding affinities for lipid and cells. In summary, this study indicates that alveolar macrophages exhibit large binding capacities for certain members of the BBIQ alkaloids. A positive correlation was observed between binding affinity to alveolar macrophages and the reported antifibrotic potency of these compounds, suggesting that the ability of these drugs to interact with alveolar macrophages may be a key step in inhibition of the progression of silica-induced pulmonary disease.

Jan 1, 1991

By A. Pavlides

The purpose of this work is to conduct a preliminary analysis of the spatial variations of the thickness of lignite layers in the area of the Amyndeo mine, and to estimate the lignite reserves of the mine. The reserves are estimated by the method of the Voronoi diagrams, using a group of mirror points to close the polygons around the boundaries of the mine. Two data sets are investigated. The first one corresponds to an exhausted part of the mine. The derived reserves estimates are compared with the actual data obtained by the Public Power Corporation (PPC) to validate the analysis. The second data set extends over the entire mine, and it is used to derive an approximate estimate of the total lignite reserves. A geostatistical analysis of the total layer thickness is performed. The experimental semivariograms are evaluated for both data sets in different spatial directions. Two possible theoretical models for the experimental semivariogram (the exponential and a novel Spartan model) are compared and discussed. An interpolated kriging map of the total thickness variation is produced accompanied by a map of the kriging precision. The performance of kriging interpolation is discussed in terms of cross validation measures.

Jan 1, 2007

By Hu Wenjun, Li Maonan

Mine ventilation systems mostly are ventilation networks with fixed-quantity branches. The solution to the problem of ventilation networks with fixed-quantity branches is obtained by choosing the fixed quantity branches as chords and using Hardy Cross iteration method. The solution usually is feasible but may be not economical. This paper takes minimal annual ventilation electricity cost as an object, considering the power of main fans and boosters, natural ventilation pressures and resistances of regulators, and builds up a nonlinear programming model. A set of initial values of the nonlinear programming can be obtained by using Hardy Cross method, The MAP technique then used to find a set of local optimal solution The running procedure with a simple example is dicussed. Mine ventilation systems mostly are ventilation networks with fixed quantity branches. In the networks, air quantity of branches are generaly regulated by increasing branch resistance or air pressure. A comon approch to the of the networks with fixed quantity branches is to formulate it based on Kirchhoff's current and voltage laws and the solution is obtained by Hardy Cross iterative technique. The solution usualy is feasible but may be not economical. The optimal plan of air quntities regulation of mine ventilation network should be to make the solution satisfy both required quantity of work places and minimal ventilation operating cost. It is the purpose of this paper to introduce a new approch and computational experience of nonlinear programming of the optimal problem.

Jan 1, 1991

The minerals industry contributes to the economic growth, prosperity and quality of life of nations, particularly in areas where there might be limited opportunities for employment in other sectors. However, notwithstanding their economic importance, the minerals extraction and processing industries are considered to have significant impacts on the surrounding environment. In recent years many mines have implemented modern monitoring technology and modelling of the monitored environmental parameters to provide scientifically proven indicators about the state of the environment. The flexibility required by the minerals industry to respond dynamically to a changing natural, social and economic environment has become a major consideration. Whilst the notion of continuous improvement is embodied within most environmental management systems, what is now required is a structured audit trail which tracks the flow of resources through the production process to the ultimate environmental impact associated with their consumption, transformation and disposal. Imperial College is coordinating an EC funded project, which is developing a methodology to minimise the ?full life-cycle? impact of metalliferous mining projects, adopting an integrated approach to production and process design, and the costs involved. In order to develop a life cycle assessment (LCA) system that will incorporate different types of data related to the minerals extraction operations, a data inventory was designed and coded in an object-relational database model. The calculation procedures accounting for the input/output balance of the alternative scenarios for mining production, processing, waste disposal, monitoring, and their financial implications are being programmed into a software system. This paper presents the rational and innovative aspects of this work. The methodology developed for the life cycle database is illustrated for the mining production and gaseous emissions components of the system.

Jan 1, 2003

By W. J. Wuest, M. J. DeMarco, J. R. Koehler

Yield-pillar-based gate-road designs often fail to provide mine operators with adequate ground control. This is because of the unknowing m is employment of "critically" sized pillars. A "critical” pillar is one that is too large to either yield nonviolently or to yield before the roof and floor sustain permanent damage and is too small to support full abutment loads. To demonstrate the critical pillar concept, afield study of a tapering gate road was conducted by the US Bureau of Mines at the Sunnyside Coal Mines, Sunnyside, UT. Extreme pillar stresses and associated coal bumps characterize the response to first panel mining of a 16.8-m (55.1-ft) wide critical design. Significantly lower pillar stresses, early yielding of the pillar and adjacent panel rib, and an absence of coal bumps suggest that a narrower 12.2-m (40-ft) wide design more closely approaches proper yield pillar dimensions. A probe hole in several 10.6-m (34.8-ft) wide pillars revealed low stress levels and substantial pillar and panel rib yielding prior to abutment onset, indicating a properly functioning yield pillar design.

Jan 1, 1997

By Shijie Wang

The metals of value in tetrahedrite are copper, antimony and silver. A new hydrometallurgical process is proposed to recover these metals from tetrahedrite. The process consists of leaching concentrate with ferric fluoborate, solvent extraction, electrowinning and residue treatment. Products from this process are high-purity SX-EW copper and antimony and a high-grade silver residue that will be further treated in a hydrometallurgical process for early release of silver. The process has advantages, such as achieving rapid leaching rates at modest temperatures with high metal recovery. Most pyrite is not attacked. Thus, it remains in the leach residue along with elemental sulfur.

Jan 1, 2003

By S. L. Jung, T. L. Nichols, K. Prisbrey

The problem was to evaluate the on-line detection of rock properties through acoustic emission sensors. Acoustic emission sensors, when attached to crushers, grinders, and roof bolters, are robust, economical, and relatively maintenance free. Our objective was to relate acoustic emissions to rock fracture mechanisms, including micropore closures, linear elastic deformations, and crack propagation. We evaluated acoustic emissions from steel jacketed rock cores during indentation tests. In addition we attached sensors to the rotating shaft of a rock bolter drill. A back propagation neural network "learned" rock fracture characteristics and rock type with 99% classification accuracy. A neural network's calibration and computational abilities suggest better acoustic emission sensor capabilities.

Jan 1, 1993

By Y. Topkaya, R. E. Johnson, B. R. Palmer, Jia-Jun Ke, Da-Ping Kang

The kinetics of the leaching of antimony oxide ore (Sb2O4) in aqueous hydrochloric acid solutions has been investigated. This dissolution reaction is a heterogeneous solid-liquid reaction. It has been found that the leaching temperature and the concentration of hydrochloric acid turn out to be the significant influencing factors on the leaching rate. The apparent activation energy for the leaching reaction was determined to be 63.5 W/mol within the experimental temperature region of 50O to 90O C. The experimental results indicate that the leaching process is controlled by the rate of the chemical reaction.

Jan 1, 1993

By Stephen Pogorski, Colin R. Phillips, Atika Khan

An optimized counting scheme for a mixture of radon daughters and thoron daughters typical of Ontario mines, developed in a previous study, was experimentally examined under mine conditions. The counting scheme requires a 10 minute sample and 5 1/2 hours counting instead of a 60 minute sample and more than 40 hours counting as required by a previous method. Taking into account the uncertainties associated with concentrations, flowrate and radioactive decay, the precision of the counting scheme was analyzed and found to be on average better than the 40 hour method.

Jan 1, 1981

By Wen-Long Cai, A. Frederick Banfield

This paper investigates, through case studies on a porphyry copper and a coal deposit, the differences and relevances between an approximate production schedule approach, i.e., the best case and the worst case schedules and a practical production schedule approach. The comparisons were with regards to: 1) choosing an optimum ultimate pit size, 2) determining processing capacities, 3) selecting 'optimum' cutoff grades, and 4) blending. The comparison criteria was to maximize the project net present value. Conclusions were drawn based on the study results.

Jan 1, 1996

By Peter C. Lighthal, Harvey N. McLeod, Iain G. Bruce

This paper describes the practical aspects of handling cyanide leach tailings. Alternative systems for cyanide destruction are briefly discussed. The provision of adequate retention time to allow natural degradation of cyanide during summer months is the most economical method of cyanide destruction. Cyanide in ground- water can frequently be both persistent and mobile, so that tailings basins should be designed to limit seepage. Common methods for limiting seepage are presented. Other aspects addressed are water balance, winter operation and abandonment of cyanide tailings systems. A case example of the Cheni Gold Mines Lawyers Creek Project tailings handling system is presented.

Jan 1, 1987

By Song Xiaotian

In this paper the enviroment in which Tong Kuang Yu mine, China is developed is described. Geological and geomechanical environments which pose difficulties in the design and optimization of Block Caving are discussed. According to mine conditions, caving process simulation was carried out using Displacement Discontinuty Method and relationships between stress distribution .and undercut parameters were established in accordance with different undercut sequence. Based on simulation the influences of caving parameters on caving probability, drift instability and ore-draw control were analysed in order to optimize Block Caving Mining. On the basis of simulation and mathematical programming, the optimal sequence is proposed essential to satisfy the safety, production and other restrictions.

Jan 1, 1989

By T. Brady, J. Johnson, J. Whyatt, B. Pariseau, M. Stahl

An elastic-viscoplastic material model allows for time- dependent rock mass motion in proportion to excess stress above the elastic limit. The model produces rounded stair-step curves of displacement vs. time that are similar to those obtained from recent borehole extensometer measurements made in the central portion of the Ross Shaft pillar at the Homestake mine. The work in progress, including two- and three-dimensional finite element analyses using the UTAH2/3 codes, indicates that the model is a step towards more realistic safety and stability analysis, but that inclusion of rock mass damage may be desirable.

Jan 1, 2000

By A. Marabini, J. Cases, M. Barbaro

Outlined is a review of the application of new selective chelating reagents as flotation collectors; calculation methods for the selection of chelating structures, limitation of the function of commercial chelating agents as collectors, and the synthesis of two new classes of chelating collectors with mixed aliphatic-aromatic structure for oxidized lead-zinc ores. Given are: examples of substituted mercaptobenzothiazole and aminothiophenol structures, flotation and adsorption study of an alcoxyl-mercaptobenzothiazole on cerussite, comparison of adsorption of conventional and chelating collectors, study of the influence of the aliphatic structure1 component on the collecting power of chelating type reagent and the design of chelating collectors with optimal structure.

Jan 1, 1989

By Phil D. Newman, Robert J. Pine, Kevin Ross

The Stratoni Operations in northeastern Greece rely on a selective backfill method to exploit high-grade lead-zinc deposits. Underhand cut and fill often results in spans approaching 6-9 m (depending on the mining method employed) and a competent backfill is required to avoid dilution problems. Cement consumption represents a significant mining cost and through improving the control of the backfill batch preparation, the cement content could be greatly reduced without jeopardizing the grade control. A new distribution system was installed and a QAIQC system designed in cooperation with the operators to allow a wide range of backfill recipes, providing cost savings to the mine. A review of possible failure modes and the consequent strength required for the chosen mining method was also completed and indicated potentially significant cement content reductions. The calculations are supported by 12 years of experience at the mines which provides a valuable insight into the applicability of the approach developed.

Jan 1, 2001

By K. A. Natarajan, M. K. Yelloji Rao, P. Somasundaran

The bacterium Thiobacillus ferrooxidans triggers the surface modification of sulfide minerals to provide hydrophilicity or hydrophobicity for the flotation of sphalerite and galena. The effects of initial cell concentration, period of biotreatment and pulp density on the floatability of the minerals are discussed. With galena, flotation enhancement obtained through sulfuric acid treatment was retarded by biotreatment at all cell concentrations due to chemical effects. Such a decrease occurred for sphalerite only at cell concentrations sufficiently high for bacterial attachment to the mineral surface. The variables affecting surface modification (and, thus, flotation response of the minerals) include the cell concentration used for bacterial conditioning, the period of biotreatment and the pulp density. Although bacterial growth during biotreatment was observed even in the absence of nutrients, such growth was more common in the sphalerite suspension than in the galena suspension. Cell protein estimations suggest that more cells are attached on galena than on sphalerite. Probable reaction mechanisms associated with bacterial modification are discussed.

Jan 1, 1993

Ever since A Decade of Digital Computing in the Minerals Industry was published in 1969, mining men have expressed the need for an additional reference on computer methods. It was felt such a volume should spell out the "how to" of computer applications in the solution of their problems. Computers in the minerals industry will be 20 years old when the 1979 SME Fall Meeting and the 16th International Symposium on the Application of Computers and Operations Research in the Mineral Industry (APCOM) take place jointly in Tucson, AZ. On such an occasion it was thought appropriate to publish an anniversary volume which reviewed current practices and projected what might prevail as computer methods for the future. Thus was born the idea to publish Computer Methods for the 80's. The first planning meeting for this volume took place in Las Vegas, NV, during the 1976 annual meeting of the American Institute of Mining, Metallurgical, and Petroleum Engineers. It quickly became evident that no single computer method existed to solve most mining problems; rather, mining computer methods are generally tailored to fit unique geologic, mining, and organizational conditions. Hence a format which included both the theory and practice for each of the computer applications was adopted for this volume.

Jan 1, 1979

By H. Nakazawa, A. S. Malicsi, K. J. Reid, P. J. Ryan, I. Iwasaki, P. W. Weiblen

Precious metals are commonly believed to be recovered along with sulfide minerals in flotation, but a few neutron activation analyses showed that the recoveries of gold and silver were unexpectedly low. Reasons for low recoveries of platinum group metals remained unresolved due to interferences in the analyses. Electron microprobe, scanning electron microscope, and scanning Auger microprobe analyses have identified nickel arsenide minerals in the ore and confirmed a close association of platinum group metals with the arsenide minerals as minute inclusions. These results indicated a need for re-evaluation of flotation procedures that have so far ignored special problems related to arsenide minerals. The electrochemical and flotation behaviors of nickel arsenide and their application to the flotation recoveries of precious metals from copper-nickel bearing Duluth gabbro are presented.

Jan 1, 1987

By D. E. Ranta, John G. Stone

One of the steps in an ore reserve estimate is customarily a rigorous calculation of the in situ grade of the orebody itself. The result of this calculation is usually reduced by some purely arbitrary factor to force the calculation to agree with the observed grade of ore actually mined. The failure of the calculation to realistically depict the grade of ore actually extracted is in many instances not the result of either an incorrect calculation procedure or of sloppy mining practice, but is a direct consequence of unsuspected irregularities in the contact between the orebody and the surrounding wall rock. A pattern of holes spaced at 1.5-3.Om foot intervals, drilled as part of a pre-development program, will often reveal that a presumed "regular' ore/waste contact is, in fact, so highly irregular that it will be next to impossible to separate ore from waste during mining. In such an instance, 'fingers' of waste projecting into the mining block will substitute for equal volumes of ore left outside the mining limits. As a result, the grade of material actually mined will be less than the grade envisioned for the orebody. The volume of waste substituting for ore in the mining block is about 0.4X, where X = the average error in projecting the ore/waste contact between alternate holes in the test pattern, and is expressed in units of volume per unit of area of the contact surface.

Jan 1, 1992

Bigger is indeed better in today's surface mining operations. That is especially true regarding haul trucks. Building larger, "supersize" trucks, however, means designing more powerful engines and drive systems that are also more efficient and environmentally friendly. And miners are demanding that these trucks have longer service lives with minimum maintenance. So truck makers are teaming with engine manufacturers and mining customers to design these larger trucks that will ultimately lead to reduced mining costs. About 180 of those truck makers, engine designers and miners gathered in Tucson, AZ in September to discuss the state of haul trucks in today's mining environment. Haulage 2000 was sponsored by World Mining Equipment and attracted attendees from around the world. Manufacturers described the latest in haul truck advancements. These included the design of more powerful engines, improvements to mechanical and ac and dc drive systems and suggestions on how to reduce maintenance spending. Technology improvements in tires for larger struck was discussed as was the cost efficiency of new, lighter-weight bed liners. The following is a summary of a handful of the presentations.

Jan 1, 1997