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By P. Wearden, K. Bryner, K. Vrana, V. Castranova, R. Dey, R. Reist, J. Blackford

"Summary: Fibroblast proliferation and enhancement of collagen synthesis are key steps in the development and progression of pulmonary fibrosis. The current investigation presents a fibroblast proliferation assay to detect the release of competence factors from pneumocytes. The specific objective of this study was to define cell culture conditions for fibroblasts that would allow selective detection of competence factors in test media. The results indicate the following: (a) fibroblasts should be cultured for 2 days in plasma-free medium rather than 2% plasma to assure complete quiescence; (b) 1% plasma was optimum for producing progression activity for the bioassay of a competence factor, while 0.5% plasma did not produce sufficient progression activity (yielding false negatives) and 2% plasma often contained significant competence activity (yielding false positives); and (c) fresh plasma should be used since the progression activity of plasma was adversely affected by freezing and thawing. Under these conditions, this bioassay can be employed with either rat or human lung fibroblasts to detect competence factors such as platelet-derived growth factor (PDGF), at levels as low as 25 ng/ml.Fibrotic lung disease, as a consequence of occupational exposure to silica dust. is characterized by the development of concentric hyalinized nodular lesions in the lung and the progressive loss of pulmonary diffusion capacity. Proliferation of pulmonary fibroblasts and enhanced synthesis of collagen by these pneumocytes have been shown to be key steps in the development of chronic silicosis ( 1 ). The regulation of lung fibroblast proliferation by cytokines released from alveolar macrophages may be an important pathogenetic mechanism in the development of the fibrotic process (2). Some cytokines stimulate fibroblast proliferation by activating specific phases of the cell cycle (3,4). In particular, platelet-derived growth factor (PDGF) promotes fibroblast proliferation by inducing the movement of quiescent (G0 ) cells into the G1 phase of the cell cycle (5). Insulin-like growth factor (IGF) and transforming growth factor-P (TGF-P). on the other hand, regulate the rate of transition of fibroblasts from G 1 into the S phase (5,6). These two classes of cytokines have been termed competence and progression factors, respectively. One approach used to examine the release of cytokines from macrophages is the fibroblast proliferation assay in which quiescent fibroblasts are exposed to culture supematants from macrophages exposed to various stimuli. In most of these assays, the supernatant contains fetal calf serum (FCS), which provides the competence factor(s) necessary to facilitate the proliferation of fibroblasts (7-9). Recently, a fibroblast proliferation assay using platelet-poor .plasma [lacking competence factor(s)] as a substitute for FCS bas been described (I 0, 11 ). In this assay, the release of a competence-inducing PDGF-like growth factor from rat and human macrophages can be distinguished from other cytokines that act as progression factors."

Mar 1, 1992

By L. W. Berger, R. I. Jaffee, D. N. Williams

The effects of hydrogen on the properties of binary Ti-A1 alloys containing 2.5, 5, and 7 pct aluminum and ternary alloys of the same compositions with added interstitial elements oxygen, nihrogen, and carbon were studied. Aluminum increases the apparent hydrogen solubility of the a-phase, resulting in a marked increase in resistance to impact embrittlement. In the Ti-5Al and Ti-7Al alloys, for example, the addition of 180 and 305 ppm hydrogen, respectively, did not cause embrittlement, while unalloyed titanium was embrittled by as little as 75 ppm. The role of aluminum in increasing hydrogen solubility of the a-phase probably accounts for the excellent hydrogen tolerance of a-ß alloys containing considerable amounts of aluminum. There is some evidence that aluminum retards the rate of hydride precipitation. If so, these alloys may be susceptible to slow-strain embrittlement. UNALLOYED a-titanium is extremely sensitive to small amounts of added hydrogen in that there is a marked decrease in notch properties. For example, as little as 100 ppm hydrogen is sufficient to lower the room-temperature notch-impact strength from over 100 to less than 20 in.-lb.' This loss of impact Strength has been associated with the Presence of hydride phase in the microstructure. Hydrogen in the amounts encountered in commercial practice

Jan 1, 1959

By D. Mohapatra

Extraction of Al(III) from aqueous sulfuric acid solutions into organic Cyanex 272®-carbon tetrachloride systems was investigated from a multi-component mixture containing aluminum, cobalt and nickel. Al(III) extraction efficiency was quantitative with 1.0 M Cyanex 272® in two stages at an aqueous: organic (A:O) phase ratio of 1:1 and an equilibrium pH of 3.2. The stripping of Al(III) from the loaded organic (LO) with different acids indicated sulfuric acid to be the best stripping agent. More than 99% stripping of Al(III) from the LO was achieved using 2 M H2SO4 at an A:O phase ratio of 1:1 in a single stage. The stoichiometry of the extracted species of Al(III) was determined by the slope analysis method. The extraction reaction proceeded via the cation exchange mechanism and the extracted species was assumed to be AlA3?3HA, where HA refers to the dimeric and A the anionic form of the extractant, Cyanex 272®. The extraction of Al(III) was studied in the presence of various ions to ascertain the tolerance limit of individual ions.

Jan 1, 2008

By John Dean Smith

In order to discuss problem solving techniques for the future. we must first review the past. This paper will discuss the drilling and blasting problems and techniques that were used by .Imax Coal in the past few years, tn those of today.

Jan 1, 1991

By Mike McWha

Drivers to increasing RM use ?Compliance issues ?Section 12 JSE Listing Rules ?Canadian NI 43-101 ?Sarbanes Oxley ?Shortage of African ore reference materials ?Poor perceptions about quality of some local RM?s

Jan 1, 2005

The early development patterns of both Australia and New Zealand were substantially in parallel and both were heavily indebted to gold mining for, providing the stimulus to growth. However, since the mining boom, of 1895 - 1899, the mining sector in New Zealand has progressively declined, while in Australia it has assumed an increasing importance in the economy. The continued dominance of minerals in Australian trade, and the fact that eight out of the top ten companies in Australia are directly involved in mineral exploration and production, has strongly influenced government and public attitude's to the minerals sector. Although the legal framework of mining and exploration Acts and Regulations are similar it is in, the method of administration, particularly in regard to exploration and prospecting licences, that the gulf across, the Tasman is apparent. Despite the relative ease of application and granting of licences in Australia, in the more settled south eastern part of the continent we are finding more and more land is being zoned unavailable for exploration. In the remote areas, the Aboriginals now control nearly ten per cent of the land area of Australia, virtually with drawing that portion from exploration. The concept of 'Australianisation' has softened a hardening attitude against foreign investment in mining on the part of the bureaucracy. This anti-mining attitude is fortunately, not shared by the public, and we can but hope that the will of the Australian people can filter through to our masters in Canberra, and ease the rapid increase in the number of regulatory bodies which does so much to inhibit the normal conduct of business. The delays caused by interminable hearings and committee investigations all cost money. This cost can only rebound back on the end consumer, who after all is a voter.

Jan 1, 1982

By V. T. McLemore

In-situ leaching (ISL) operations have been proposed to recover uranium from sandstone-uranium deposits in NM. ISL (also known as in-situ recovery, solution mining, solution-leach mining, leach mining) consists of injecting a leaching solution into the mineralized zone through injection wells. The leach solution migrates through the formation, dissolves uranium and is recovered through production wells. The uranium is then precipitated through a conventional uranium recovery system. Several criteria must be met in order for in-situ leaching to be successful, most important is that the ore body must be amenable to chemical leaching. A number of ISL operations have been conducted in NM in the past (Mobil, Crownpoint; UNC-Teton, Section 23; Grace Nuclear, Hook?s Ranch, Seboyeta, Church Rock; Anaconda, Windwhip). Kerr-McGee (later Quivera Mining Co., Rio Algum) successfully produced uranium from mine-water recovery (recirculated mine water) from the Ambrosia Lake mines (mid-1960s to 2002). Despite some difficulties, ISL is a viable alternative to recovering uranium and could be utilized in the Grants district with proper aquifer characterization and monitoring.

Jan 1, 2009

By Vanessa C. Koppe

During ore body modeling normally additional samples are required to improve resources evaluation and mining planning. At this stage one rises the question about where additional samples should be located. Regular sampling pattern seems to be a reasonable choice, since all the regions within the deposit receive the same number of samples without a clear clustering. Nevertheless, values for certain attributes (grades for instance) from a mineral deposits may behave more erratic in some regions than others. Consequently, by adding samples to these regions could bring more benefit for reducing the uncertainty related to a transfer function such as Net Present Value (NPV), instead of adding samples to location of low grade uncertainty. Thus, for a given number of additional data, the test of a regular pattern and a pattern which add samples on areas of high uncertainty of the attribute of interest is worth. This paper presents an algorithm that allows the construction of these two patterns, automatically, on a software commonly used in the mining industry. The algorithm leads to a fast analysis on the efficiency of the two patterns in reducing the uncertainty associated with a transfer function.

Oct 1, 2009

By R. S. Dean

[In E;encralt the I~8:al:ul',~,C,-J. Div:'sion conducts in\'8stigations relat-ing to the treatment of OrGR o.nd L!\3tallurl..'"lcal prod tctR froJ] t~e condi tion in :hich they are Itinod to t!1e refi!l(,u r.etal, . ' th 'the ob,icct of conserving natmal' resources .e..nd 81:mir..3.tin~ wacte by furn.i:::hir..g :nforInf'_tiou on current methods of metal11:.rgical practice, Tfu'..:.kir..g fund T!l;ntal .;;.otudie'" of metal-lurgical processe~, and de~eloping ~e~ proc6sses O~Q lloys to the point of dewonctrati:r:g the:'..r practicab'lity or va.lue}

Jan 1, 1941

By E Topal

Stopes are used in several underground mining methods. Boundary determination of these stopes is generally based on simple rules of thumb. While several stope boundary optimisation techniques are available, they fail to guarantee true optimum results. The first part of this paper reviews some important stope boundary optimisation studies and proposes a new algorithm to optimise stope boundaries and layouts for underground operations. The second part applies the proposed algorithm to a block model to test its ability to produce optimum results and demonstrate its applicability in a number of different scenarios. The results demonstrate that the proposed algorithm can find optimum stope boundaries and layouts in three dimensions for different stope sizes and economic conditions.

Jan 1, 2009

By Daniel Ng

The U.S. Bureau of Mines-Michigan Technological University mine ventilation mainframe program was successfully adapted for execution in a personal computer (PC). The hardware requirement can be as modest as 256 kilobytes (33) of random access memory (RM) and two floppy disk drives. A version compiled for a PC possessing 512 Kb RAM has arrays dimensioned to accommodate 512 separate mine airways and junctions, and it contains all the features and capabilities of the original version. It has successfully analyzed all the ventilation networks tested, including a very large commercial mine (404 airways, 237 junctions, and 5 fans). In all cases the PC version produced practically identical results as obtained from the mainframe computer. In all respects, the PC version performed the same as the mainframe version with the exception of execution speed When a numerical coprocessor is employed, execution time can be reduced by more than 50%.

Jan 1, 1989

By Sandip K. Mukherjee

This report presents the results of the economic analysis of several applicable alternatives to increase airflow in four underground coal mines. Pressure-quantity surveys were conducted underground and measurements were also made at the main mine fan(s). The existing ventilation networks were modeled using the modified Penn State ventilation simulator. The applicable alternatives were simulated. Performance data obtained from these simulation runs were utilized to conduct the cost-effectiveness analysis. The costs for each of the alternatives included capital, operating and operating costs. These costs were expressed as annual ventilation costs per active section in terms of dollars per cfm taking into account the economic life associated with each of the alternatives. The benefits were expressed as increased airflow quantity in the critical sections. A section of this report also deals with comparison of simulator predicted air quantity values against air quantity values measured under-ground. This volume constitutes Volume II of the report and contains the outputs of the computer simulation runs.

Jan 1, 1983

The recovery of coarse particles has been widely recognized as being limited by the froth in mineral flotation. In response to this, FLSmidth has developed the Selective Froth Recovery (SFR) System. The SFR System is an extraction system that vacuums material from select locations within the froth and separates the recovered solids into coarse and fine fractions with a hydrocyclone. The SFR is supported and located by an actuator connected to the cell?s level control so that the suction heads are maintained at an offset distance from the slurry level. This can increase the recovery of coarse material by selectively recovering the material close to the bottom of the froth where drop-back of coarse particles typically takes place. The SFR System has been tested at two separate mine sites, and has been proven to increase the copper recovery in both trials. TEST RESULTS The SFR prototype was installed in a copper recovery circuit, on a rougher scavenger 160-m3 flotation cell. Figure 1, shows the SFR System, which consists of four conical skimmer heads that are plumbed together and share a common actuator. The SFR System, raised out of the froth prior to a test, can be seen in Figure 2. The SFR prototype was able to maintain a variety of set points using the level control to determine the slurry height.

Feb 27, 2013

By Scott Orenstein

Construction blasting has allegedly been the cause of property damage in the following situations: (1) When the detonation of the shot hurls rock and debris into the air that causes property damage upon impact; and (2) When property owners notice cracks in their walls and foundations after they experience the momentary vibrations that coincide with the detonation of the shot. The current state of the law for both these situations is firmly established. Blasting is classified as an abnormally dangerous activity, for which the blaster is held strictly liable, whether the damage is the result of flying debris or vibrations and concussions generated by the blast. It is when the alleged blasting damage is supposedly from concussions and vibrations, however, that the courts usually reach the wrong result. The typical scenario involves property owners that thoroughly investigate their property after feeling blast generated vibrations, and find cracks that they believe did not exist beforehand. Most often the truth is that the property owners have never noticed these cracks before because they have never looked that closely before. Any structure has a certain number of cracks due to a variety of causes, such as settlement overtime and temperature and humidity changes.

Jan 1, 2004

By A M. Sherwood

The Otago and Southland lignite deposits represent by far the largest known fossil energy resources in New Zealand. Despite their size they have remained virtually untouched since exploration in the 1970s and 1980s defined their extent. In total there is an estimated 10.9 billion tonnes of lignite in 13 defined fields in Otago and Southland. Much of the exploration work only targeted seams at shallow depth and it is highly probable that there are further resources at depth in the fields that have been explored to date.   L&M Lignite Limited (L&M) holds exploration permits over a number of lignite deposits and is currently engaged in pre-feasibility studies to investigate the potential of the lignites for gasification. L&M is focussing its studies on the Hawkdun and Ashers-Waituna deposits. Coal quality in these deposits, particularly Ashers-Waituna, is highly suitable for gasification. In total the two deposits contain 1647 Mt of potentially recoverable lignite. L&M has engaged a variety of consultants to progress this project. The Hawkdun and Ashers-Waituna deposit databases have been re-evaluated and the resources remodelled. Further drilling has been carried out and the coal quality database has been expanded. The baseline project is to develop a mine to feed a plant that will produce liquids, specifically low-sulphur diesel and naptha, using the Fischer-Tropsch process. The project anticipates a staged development of 10 000 barrel per day units, each requiring mining at the rate of 12 700 tonnes of lignite per day. The production of other products including ammonia-urea, methanol, hydrogen and electric power is also under study.

Jan 1, 2005

Microorganisms are finding more use in the mineral industry, with extensive research efforts being reported in 1991. Most of these research efforts were presented in two major meetings, the SME Annual Meeting in Denver (February, 1991) and the Engineering Foundation Conference about Mineral Bioprocessing in Santa Barbara (June 1991). In addition, several articles were published in the IMM Transactions, Minerals and Metallurgical Processing and Water, Air. and Solid Pollution Journal. The literature can be categorized as: • Review articles presenting an overview of the activities in the use of biotechnology in mineral processing. • Research efforts into genetic manipulation of microorganisms to perform a specified job. • Studies in bioleaching of metals from different types of ores. • Biotreatment of wastes from the mineral industry including acidic mine waters, uranium tailings, cyanide destruction, etc. • Investigations into the role of microorganisms in the energy materials, such as oil, coal, tar sands, oil shales, etc. Smith (Mineral Bioprocessing Conference) presented a review of research efforts as well as practical applications of biotechnology in the mineral industry. In another article, Smith et al. (Minerals Engineering) emphasized that extensive fundamentals and applied research work should be pursued to explore the fundamentals, potential and practicality of the various possible uses of microorganisms in mineral engineering.

Jan 1, 1992

By Samantha Beeson, Collin Poole

"This paper examines the development of two new selective flocculation techniques for recovering KCI values from low grade carnallite potash ore.Direct recovery of KCI was achieved using one of two mid-range molecular weight polymers, one non-ionic and the other strongly cationic, in conjunction with the same selective anionic dispersant. From initial response studies on pure minerals and selective flocculation tests on synthetic mixtures, investigations were extended to recover KCI values from a natural carnallite potash ore. A single-stage process achieved products grading up to 61.3% KCI at recoveries up to 85.4% for the cationic flocculant suite and up to 64.8% KCI with recoveries as high as 90.3% for the non-ionic flocculant suite, with dispersant and flocculant dosages of 150-250gr1 and 10-75gr1, respectively. These results clearly demonstrate not only the feasibility of treating such problematic ores at low reagent dosages, but also the potential elimination of desliming prior to froth flotation.The experimental results presented are considered in terms of the reagent adsorption phenomena present in the system and various aspects of floe formation and cleaning.IntroductionAs high-grade sylvinite potash ores become scarce, lower grade sylvinite and carnallite potash ores are becoming more attractive. However, these ores often contain large amounts (up to 15% by weight) of water-insoluble slimes which must be removed prior to KC! flotation, owing to their high adsorptive capacity for the amine collectors used. The slimes are generally removed by scrubbing followed by hydroclassification and any residual material not eliminated is blinded with reagents such as guar gum or starch to inhibit interference in subsequent KC1 flotation.An alternative approach used commercially in Canada by Agrium Inc. involves water-insoluble slimes flotation prior to KC! flotation. In this process, the slimes are selectively flocculated and then separated by froth flotation. Losses of KC! to the slimes product and associated brine requirements are both reported to be less than those encountered in conventional desliming, but the technique is somewhat limited in its application at present."

Jan 1, 1997

By C. D. Thompson

Pile load test programs were carried out in 1984 and 1985 at Stelco's and Dofasco's Steel Making Plants in the Hamilton Bayfront area. 323.9 mm outside diameter by 9.5 mm wall thickness Grade 3 steel closed-end pipe piles were driven to practical refusal at depths of 21 to 30 m in very dense silt till with Delmag D30 open-end diesel hammers. Ultimate bearing capacities of up to 5330 kN were proved by dynamic monitoring and static load tests. Allowable bearing capacities of 1780 kN were achievable on production piles without undue difficulty. It was found that the impact stress at the top of the pile was controlled by the yield strength of the steel rather than a useable upper limit based on the modulus of elasticity. A bearing to impact stress ratio of 1.2 at practical refusal was observed to be reasonable but conservative at this site, and is felt to be generally applicable for piles driven to practical refusal elsewhere. Dynamic monitoring during production pile driving was able to show that apparent relaxation was caused by pre-ignition of the hammer when visual observations indicated that pile driving was proceeding satisfactorily.

Jan 1, 1987

By Steven W. Hunt, Safdar A. Gill

Design and construction of temporary shafts for underground facilities often require evaluation of bottom stability due to rupture (blow-ins) caused by water pressure acting on a bottom plug. This paper provides an overview of shaft bottom stability evaluation methods for the case of a relatively watertight soil plug which overlies an artesian aquifer. Methods of considering plug perimeter shear, plug buckling and pressure relief are discussed. Minimum factors of safety are suggested. Future use of the shaft subgrade is also considered. Bottom plug failure case histories at several shafts are evaluated. This paper should be useful to project designers, ground support system design engineers and contractors involved with construction of shafts for underground facilities

Jan 1, 1997

By Paul G. Swanson

This investigation was conducted to identify the principle causes of spoil instability problems in the Eastern Coal Province. The study was also conducted to develop a matrix to predict the strength and groundwater parameters necessary to conduct stability analyses on a proposed reclamation scheme. Suggestive methods to reduce spoil instability potential are also included. Numerous physical property, strength, compressibility, chemical and mineralogical tests were conducted on mine spoil samples obtained from 11 different surface mine sites. Site characteristics that influence the position of the post reclamation groundwater table were identified. Distinct regions within the Eastern Coal Province with high incidences of surface mine slides or high landslide susceptibility were identified. The application of the predictive matrices developed in this study is for surface mine sites mined and reclaimed in general accordance with the Surface Mine Reclamation Control Act of 1977. A review of current mining practices and the relative effect on spoil stability is included.

Jan 1, 1983