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By Diane Schwegler-Berry, Vincent Castranova, Chang-geng Moe, Jane Y. C. Ma, Mark D. Moore, Joseph K. H. Ma, Carl J. Malanga, Ji-Hee Kane

"Effects of Bisbenzylisoquinoline Alkaloids on Alveolar Macrophages: Correlation between Binding Affinity. Inhibitory Potency and Antifibrotic Potential. CASTRANOVA, V., KANG, J-H., MA. J. K. H., Mo, C-H., MALANGA, L. J., MOORE M. D., SCHWEGLER-BERRY, D.. AND MA. J. Y. C. (1991). Toxicol. Appl. Pharmacol 108, 242-252. The Chinese have conducted extensive studies concerning the medicinal properties of plant products. In this investigation the ability of three bisbenzylisoquinoline alkaloids to inhibit particle-induced activation of alveolar macrophages was evaluated and this inhibitory potential was correlated with the ability of those drugs to bind to membrane components. Tetrandrine. i.e.. an herbal medicine used as an antifibrotic agent in China, was a potent inhibitor of particle-stimulated oxygen consumption, superoxide release, and hydrogen peroxide secretion by alveolar macrophages. Tetrandrine also exhibited substantial binding affinity for membrane lipids and alveolar macrophages. In contrast, tubocurine, an analogue with little antifibrotic potential, exhibited low binding affinity and had little effect on macrophage activation. Methoxyadiantifoline, an alkaloid of unknown antifibrotic potential, exhibited inhibitory and binding properties similar to those of tetrandrine. The data indicate that a strong relationship exists between the antifibrotic potential of these alkaloids and their ability to bind to alveolar macrophages and inhibit particle-induced activation of these phagocytes. These drugs should serve as useful probes to evaluate the role of alveolar macrophages in pulmonary fibrosis. © 1991 Academic Press, Inc.Chronic silicosis is a fibrotic disease resulting from occupational exposure to silica dust. It is manifested initially by an increase in the quantity of pulmonary surfactant (Dethloff et al., 1986). However, in later stages it is characterized by an increase in collagen formation and the development of concentric hyalinized nodular lesions in the lung (Ziskind et al., 1976). Although mechanisms for the progression of silicosis have not yet been completely defined, activation of alveolar macrophages by respirable silica particles is believed to play an important role in the etiology of this disease. Studies from our laboratory have shown that both in vitro and in vivo silica exposures result in a stimulation of macrophage release of reactive products capable of damaging the lung parenchyma (Castranova et al., 1990; Goodman et al., 1990). In addition, exposure of al¬veolar macrophages to silica results in the release of fibrogenic factors which enhance the proliferation of fibroblasts and the synthesis of collagen by these pneumocytes (Leibovich and Ross, 1976; Bitterman et al., 1982, 1983).The bisbenzylisoquinoline alkaloids, which represent the largest group among the iso-quinoline compounds isolated from the plant kingdom, are known to exhibit a broad rangeof pharmacological activities. Tetrandrine, for example, an alkaloid isolated from the root of Stephania tetrandra, has been tested for its antitumor, antihypertensive, and antisilicotic effects (Kupchan and Atland, 1973; Zeng et al., 1985; Yu et al., 1983). It is currently used in China as a treatment for angina, hypertension, and silica-induced pulmonary fibrosis (Li et al., 1981). Several related bisbenzylisoquinoline alkaloids such as methoxyadiantifoline and tubocurine have also been evaluated for medicinal effects. Methoxyadiantifoline has been shown to exhibit effects on the cardiovascular system similar to those reported for tetrandrine (Jia et al., 1988). However, to date, the antifibrotic activity of methoxyadiantifoline has not been evaluated. In contrast to tetrandrine, tubocurine, a structural analogue of this drug, has been reported to be relatively ineffective against fibrosis (Mo et al., 1982)."

Mar 1, 1992

By F. Guo

"The leaching kinetics of zinc sulphide concentrate was studied under total pressures ranging from 0.3 MPa to 0.5 MPa and leaching temperatures ranging from 358 K to 378 K. The apparent activation energy of leaching reaction under different total pressures was calculated. The results show that for the extraction of zinc at low-temperature pressure leaching is controlled by an interfacial chemical reaction. This was supported mineralogical analysis of the leaching residue. The kinetic equation for low-temperature pressure leaching of zinc sulphide concentrate was further established by quadratic regression on the basis of shrinking core model.INTRODUCTIONThe Roast-Leach-Electrowinning Process (RLE) is the primary route for zinc production and responsible for more than 85% of the total zinc production (Souza et al., 2007). During the roasting of zinc concentrates, fugitive SO2 causes pollution. The prevention of SO2 emissions from the RLE process can be one of the challenges to this technology (Deller, 2005). In the 1980s, the Zinc Pressure Leach (ZPL) process changed the concept of zinc hydrometallurgy, in which zinc sulphide concentrate is directly leached at approximately 423 K and approximately 0.7 MPa oxygen overpressure and the sulphidic sulphur is oxidized into elemental sulphur so that the pollution by SO2 is completely avoided. Since 1981, five zinc plants have adopted the ZPL process either for expansion by integration with existing roasting facilities, or for the production of zinc without any roasting at all (Collins et al. 1994; Barth et al. 1998). The innovation of the ZPL process has made the zinc industries more competitive although it needs an autoclave. The direct leaching technology of zinc is still in development."

Jan 1, 2012

By G. S. Scott

[In the course of the investigation the Bureau of Mines is carrying on to determine the causes, behavior, and control of mine fires, the detection of incipient heating underground in the mines and above ground in refuse banks has received consideration. A report has been published5/ describing apparatus and tests made on anthracite to determine the amount and composition of the a oxidation products when normal dry air was passed through it at temperatures varrying from 100° to 350° C. These tests showed that the amount of evolved gases and their relative proportions varied with the temperature. From these results, graphs were prepared by which the temperature at which the coal was oxidized could be estimated thus giving a possible means of detecting incipient heating.]

Jan 1, 1938

By Z. Y. Lan

Bioleaching of marmatite with various mixed cultures of microorganisms was investigated. The experiments were carried out in shaking flasks with iron-free nutrient and the pulp density of 10% wt/vol at the temperature of 30?. The results show that zinc is preferentially leached before iron. The leaching rate of zinc with the mixed culture of Acidithiobacillus ferrooxidans, Acidithiobacillus thiooxidans and Leptospirillum ferrooxidans is 62% in 18 days. The leaching rate of zinc with the mixed culture of Acidithiobacillus ferrooxidans and Acidithiobacillus thiooxidans is nearly the same as that with the mixed culture of Acidithiobacillus ferrooxidans and Leptospirillum ferrooxidans (45% versus 50%). SEM and EDX analysis of the leaching residues indicate that a solid product layer composed of iron sulfide, elemental sulfur and jarosite accumulates in the mineral surface and becomes a barrier to the dissolution of marmatite. The bioleaching of marmatite follows the shrinking core product layer model. When the product layer increases and becomes insoluble, the leaching rate is controlled by the diffusion through the product layer and slows down. When the product layer decreases or becomes a porous layer, the leaching rate is controlled by chemical reaction and enhanced dramatically.

Jan 1, 2014

By S Goff

The Northern Sewerage Project (NSP) is a $650 M infrastructure project that will increase the capacity of the sewerage system for Melbourne’s growing northern suburbs while also helping to protect the Merri and Moonee Ponds creeks by significantly reducing the number of sewage overflows that can occur after heavy rainfall. The NSP consists of two stages: Stage 1 (NSP1) will be owned and operated by Melbourne Water Corporation, and Stage 2 (NSP2) will be owned by Yarra Valley Water and operated by Melbourne Water Corporation.Glass-fibre reinforced plastic (GRP) was used on both NSP stages, however, since Stage 1’s schedule for installation of GRP was slightly ahead of Stage 2’s, this paper will only focus on Stage 1’s use of GRP.NSP1 involves the construction of 7.9 km of new sewer tunnel ranging in diameter from 1.6 to 2.5 m, five main access shafts at depths of up to 65 m, and connections to the existing sewerage system including several access manholes. Construction began in 2007, and project completion is expected in 2012.The original design for NSP1 specified the use of high-density polyethylene (HDPE-) line precast concrete pipes as the final tunnel lining and HDPE-lined reinforced concrete for the access shafts and manholes. During construction, the rising cost of precast concrete pipes and the introduction of an additional GRP pipe supplier in the market justified a review of the tunnel final lining material. The contractor-proposed GRP pipe alternative was accepted for the final tunnel lining based on time and cost savings that were possible without compromising the design intent. After gaining experience with GRP through this design change, Melbourne Water Corporation reviewed and accepted GRP as the final lining for five smaller connection manholes. The use of GRP for the manholes was particularly inventive as the redesign made use of the approved tunnel GRP pipes as both a structural and corrosion-resistant lining.This paper discusses the use of GRP on NSP1; how the change in material, from concrete to GRP, affected the design philosophies assumed during detailed design; and how construction methods were modified to handle the less rigid GRP material. Details on the structural, hydraulic and durability considerations for the design are included, as are details about the time and cost savings and the quality and safety improvements that were achieved during construction.

Mar 8, 2011

By Charles Vaught

The U.S. Bureau of Mines evaluated the self-contained self-rescuer (SCSR) donning proficiency of 243 miners. These workers were from eight underground coal mines in the eastern United States. The objectives of the study were (1) to gather information on skill levels, since all miners in the study had prior instruction and opportunity to practice donning the apparatus, and (2) to summarize a quality control procedure useful in conducting periodic evaluations of donning proficiency. The sampling procedure used proved to be both reasonable and efficient in gathering information on training effectiveness_ It also provided a good statistical base for making informed site-specific decisions regarding SCSR training needs. Results from the observed samples at each of the eight mines indicate a wide variability across sites. The rate at which miners failed to isolate their lungs varied from 33 to 40.0 pct. Concomitantly, proficiency rates (miners either performing adequately or demonstrating a perfect 3+3 sequence) ranged from 13.3 to 63.3 pct.

Jan 1, 1991

By W. D. Mcmillan

Soapstone is the term applied to an impure, massive, soft rock with a greasy feel. It is of variable composition, consisting chiefly, however, of talc, tremolite, and chlorite. Although limited quantities of soapstone are used as building material, in fireplaces, and in the manufacture of laundry tubs, sinks, laboratory-table tops, and-oven and furnace blocks, the principal part of the production is ground for use in roofing paper, insecticides, and as a filler in asphaltic paints.

Jan 1, 1949

By P Kirsch, P Jagals, D Viswanathan, J Shandro, R LaBouchardiere

The planning, design and operation of mines must include the development of positive environmental, community and land-use benefits if it is to achieve good corporate social responsibility and minimise detrimental impacts throughout the life of the mine. Life-of-mine (LOM) planning should, therefore, consider conducting mining activities in the best socially, environmentally and economically acceptable manner, from the commencement of exploration to post-closure of the mine. Current knowledge of LOM activities in relation to public health (life-of-community, or LOC) impacts neither fully captures the full suite of human health and well-being impacts, nor comprehensively informs society on these issues. This knowledge gap is becoming more apparent as public antipathy is increasing towards mining activities within Australia, Canada and globally. The purpose of this paper is to present preliminary and informative results of a literature review to gain insight into the extent of available public health and well-being knowledge associated with mining development. LOM development must also benefit the LOC, in that it must aim to minimise detrimental impacts, and maximise beneficial (including health) impacts on all associated communities. Health planning and programing for mitigation of potential adverse health impacts of mining should extend beyond the scope of work-related injury and illness (resulting from chronic exposure to harmful substances, infectious and lifestyle illnesses), to the health and well-being of workersÆ families and extended associated communities. By mapping the available but rather scarce literature on LOC areas to recognised LOM stages, this review found shortcomings and imbalances regarding research reporting on mining and its health-related impacts in the worker-to-community continuum.CITATION:Kirsch, P, Viswanathan, D, LaBouchardiere, R, Shandro, J and Jagals, P, 2012. Health impacts extend from the life of a mine to the life of a community - Knowledge gaps, in Proceedings Life-of-Mine 2012 , pp 161-168 (The Australasian Institute of Mining and Metallurgy: Melbourne).

Jul 10, 2012

This paper presents a theoretical investigation on the ionic equilibrium of Fe(III)?Ni(II)?H2SO4?H2O system. A non-ideal speciation model is developed to calculate the concentration distribution of iron and nickel species in a mixed ferric and nickel sulphate aqueous solution over the pH range from 0 to 4 and temperature from 25 to 100°C. A series of speciation diagrams for iron and nickel species is plotted with the effects of ionic strength and temperature on the equilibrium constants being taken into account. The ionic strength-dependent equilibrium constant is treated through a semi-empirical Vasil'eV equation, which is based on an extended Debye?Hückel theory. A Helgeson model is applied to extrapolate the equilibrium constant to elevated temperature. The ionic equilibrium reactions are described by a group of numerical equations containing the temperature and ionic strength-dependent equilibrium constants, which are solved by the Newton-Raphson method. The speciation model is also applied to estimate the hydrogen ion activities and corresponding pH values. The calculated pH values are in agreement with the experimentally measured pH, and are compared to literature data and pH values produced by the Visual MINTEQ® program (a computer code for the calculation of chemical equilibrium in natural aqueous system). This investigation provides a deep insight into the ionic equilibrium behavior of a mixed metal sulphate aqueous system which commonly occurs in hydrometallurgical processing. Keywords: speciation, chemical modelling, thermodynamics, iron, nickel

Sep 1, 2012

By J. J. Beeson

For the past fifty years or more, the structural features of the Cordil-leran mountain system of western United States have presented some most interesting problems. Any geologist or engineer living in this region, or even making occasional examinations of the mines, will lose much of interest and importance if he is not familiar with the literature. Some of the greatest works on geology have been the result of studies carried on in sections of this region. Among the more important of the earlier works are those of Dutton,l King,2 Gilbert3 and Powell;4 of the more recent Lindgren,5 Ransome,6 Spurr,7 Butler8 and others have contributed much. Many of the papers are largely of scientific interest but even these lay the foundation for the commercial application of the broader features of the geology. I have read many of these works with the keenest interest and pleasure; in fact, some have been read until some of the more important findings seem to be my own. In this paper, however, it is my aim to accept credit for little more than the labor of assembling some of the ideas of others. This is done with the hope that an interesting and valuable discussion will be the result. If some of the ideas presented should

Jan 1, 1927

By Aiming Z, Shenyi S, Xialei W

Zhangmatun Iron Mine is situated in the suburbs of Jinan city. Shandong, China. Because of surface environmental constraints, no suitable site can he selected to dispose of mill waste. The full mill tailings must be disposed of underground. This paper deals with the work conducted at Zhangmatun mine to develop a total tailings backfill system, taking advantage of a double- shaft blade mixer and an activating agitator to prepare backfill. Cement and ground slag are added to tailings for strength development. Two scopes have been filled and the pillars have been effectively mined out during the field trial. The application of innovative total tailings backfill technology is a new concept at the mine. Detailed planning has achieved a close integration of mining, milling and backfilling. Full mill tailings, with or without rock, are disposed of underground in a continuous process to fill, totally and systematically, the cavities formed by mining.

Jan 1, 1998

By AIME AIME

ON the headwaters of the Hudson Riser, in a sparsely populated area of the north woods at Tahawus, N. Y., thirty miles from the nearest railroad, is the Maclntyre property of National Lead Co. Operations involve the mining and processing of titaniferous iron ore to produce ilmenite concentrate, and magnetite concentrate containing vanadium, for use in the production of iron, titanium, and vanadium in the war program. Accordingly, Maclntyre at present is classed as a war plant. More than 3000 long tons of ore is ruined daily by opencut methods and treated in an ore concentrating plant.

Jan 1, 1943

By D. Wenstrup, K. Perry, J. Hatfield, P. Sainato, B. Lusk

Concrete-infused cloth is used in several civil and mining surface applications whose circumstances are similar to some of those in underground mining. A feature of this material is that it cannot be overhydrated. In underground conditions, however, the excess supply of water to the cloth for hydration could lead to muddy and potentially unsafe working conditions, as well as resource wastage by supplying more water to the construction site than is needed. The objective of this study is to verify the water-to-cloth ratio and study the effect of hydration level on the strength of the Concrete Cloth product. We found that the strength increases with increased hydration up to a 1:2 water-to-cloth ratio by weight, after which the strength holds steady regardless of additional hydration. This confirms the 1:2 water-tocloth ratio by weight for hydration and confirms that strength is retained even if the cloth is excessively hydrated.

Jan 1, 2014

By William Hilliard

IN any manufacturing business, it is of vital importance that the management should know the exact cost of the units of production. Without such knowledge, a company can sell blindly in the open market, obtaining the best prices it can in competition with other firms, and manage perhaps to continue in business for a time; but at any moment, and especially in a period of falling prices, such a firm is at a loss to know exactly at what point it can sell at a profit and exactly how much it is losing per unit if it sells below that point. Furthermore, it is necessary not simply to know the exact total cost per unit, but to know definitely all the different-factors which enter into that cost. A firm manufacturing pocket knives had been doing a profitable business for many years when it began to earn smaller and smaller profits, until there was scarcely any profit at all being realized. Being unable to determine exactly what its future policy should be, it called in experts who studied the past records carefully and followed out for a period a better cost, system. Investigation then showed that on several different kinds of knives in common use, a small profit per unit was being made. On a number of special kinds of knives, of which the firm was very proud, it had been forced to cut prices under the pressure of outside competition and had believed that a small profit per unit was still being made on that product, while a detailed cost analysis showed that a loss was being incurred on each knife of that kind produced. It then became clear that the company must either give up the special line and concentrate wholly on the cheaper knives and extend their sales to territory not yet developed; or expand its plant and produce more of the higher grade knives and thus lower the cost per unit enough to make money on the higher grade knives also, if conditions warranted such expansion. Investigation revealed that the market for large quantities of the high-grade -knives was decidedly uncertain and that the most promising move would be to manufacture only the less expensive knives on a larger scale. That plan was carried out and the concern began again to make a better profit.

Jan 1, 1932

By Y Nagendra, A. Ravi Kumar

A breakwater is a construction for protecting the marine structures like port, harbor, or anchorage-basin and berthed marine vessels from the destructive influence of the sea waves. The breakwater is constructed by using geologically competent, heavy, massive rock like granite, basalt etc having physical and mechanical properties within the limits specified by the designers. The construction requires boulders in varying sizes ranging from 0.5 kg to 20,000 kg. The stones from 0.5 to 1000 kg are called as core fill and boulders greater than 1000 kg are termed as armor blocks. These armor blocks cover and protect the core fill and prevent it from escaping. The requirement of armor blocks ranges between 25 to 35 %. The rest is core fill. However, the actual requirement depends on the breakwater design. In this context, the task of the mining engineer is to economically produce armor blocks and core from the designated quarry in right proportion with minimal losses. The whole bunch of engineering ingenuities should be put forth for obtaining the required armor blocks. The armor block production from any blast depends chiefly on geological conditions, bench dimensions and blast design. This paper is an attempt to bring out the various parameters affecting the performance of the blasting for armor block production using a case study.

Jan 1, 2005

By Joseph A. DeCarlo

THE TOTAL VALUE of sales of coal-chemical materials in the 10-year period 1948-57 increased 34 percent or at an average annual rate of approximately 3.5 percent. According to the Chemical Industry Facts Book, third edition, 1957, published by Manufacturing Chemists' Association, Inc., the production of industrial chemicals since 1939 "has grown at au average rate of about 10 percent" a year (p. 7). The rapid growth of the chemical industry increased requirements of chemical raw materials at a faster pace than could be supplied by coal carboniza¬tion, and view sources of supply became necessary. The petroleum industry in the past decade increased tremendously the flow of chemical raw materials to the chemical industry through the processing of crude petroleum and natural gas. Whereas coal carbonization supplied most of the raw materials for manufacturing synthetic organic chemicals before World War 11, coke ovens supplied only about 40 percent of the total used in 1957. Although the proportion of chemical raw materials supplied to the chemical industry by coke-oven operators declined, this source of supply is large and important to our economy. In 1957, the value of coal-chemical materials sold, including surplus gas used by producing companies, totaled $358 million, compared with $267 million in 1948. Major factors that contributed to this gain were (1) increased production of all coal chemicals and (2) higher prices for tax and light-oil products. Gains in output of coal chemicals resulted principally from expansion in carbonizing capacity of coke plants owned and operated by the iron and steel industry, as yields of the basic coal¬-chemical materials (tar, ammonia, light oil, and gas) varied only slightly during the 10 years under review.

Jan 1, 1959

By Shu Fan Chau, Innes Duncan, Harry Asche, Bill Newns

The North Auckland Line (NAL) in Northland, New Zealand, is being upgraded to pass Hi-Cube containers. The line includes many tunnels and bridges which need to be refurbished to improve structural clearances and line capacity. Tunnel 2 along the line, the Makarau Tunnel, has posed special challenges. Opened in 1898, the tunnel suffered multiple collapses during construction and has shown significant distortion during operation. The tunnel has been repaired many times since opening. Successfully enlarging this delicate and distressed structure has involved historical research, advanced analysis and design, and careful construction. The results provide lessons for dealing with brick lined tunnels and poor ground conditions

Jun 13, 2021

By H. Dale Nichols

[The growing importance of the Sundance (Jurassic) formation as a source of oil in the Rocky Mountain area has prompted the making off a series of porosity determinations of core samples collected from the reservoir sands of the Lance Creek oil field, Niobrara County, Wyo. These analyses are preliminary to a study of fluid and energy relations in the Basal Sundance reservoir of that field, and the determinations of porosity will be used in subsequent studies requiring calculations of the volumetric capacity of the reservoir and estimation of the reserves of oil and gas.]

Jan 1, 1938

By S. Pastor, S. Hahn

"As the concept of autonomous haulage systems (AHS) moves from proto-types to production-ready applications, the operating performance of the haul road will become ‘mission critical’ to the overall success of autonomy in mining. Deterioration in road performance will require remediation, human intervention and significant, albeit temporary, changes to operating procedures, to accommodate road maintenance. With autonomous trucks comes the opportunity to reduce road formation and operating width, and therefore generating potentially significantly reductions in stripping ratios and improvements to mine economics, but only if the design of the road, and it’s associated deterioration rate, is predictable and manageable, based both on the materials used to construct the road and the maintenance interventions to be carried out on the road. This paper presents the assessment of a digital photogrammetric approach to the characterization of a mine haul road surfacing, or wearing course material. Design and maintenance parameters for these roads are currently determined from physical particle size distribution (PSD) assessments of ‘in-road’ material. However, this approach does not accommodate the need, nor leverage the benefits from, AHS. The digital imaging approach is assessed in this paper, using two standard digital analysis software tools, together with in-service mine haul road wearing course samples and images which are assessed to determine the applicability and reliability of the approach to deliver a real-time assessment of haul road surfacing conditions and thus to identify the road maintenance interventions required to address deterioration. INTRODUCTION Enhancements in mine road design, construction and management for the past 20 or more years has largely been focused on short-term tactical needs. These improvements have not been matched by advances in the fundamental technologies that underpin mine road design and management, and although the quality of mine roads have probably increased, many of fundamental and longer-term issues have yet to be addressed. With AHS’s evolving from prototype to production applications, any decision to implement these systems in a mine requires a thorough evaluation of impacts, not only operational improvements, but the inter-connectivity of this autonomy technology to other organizational processes. In developing an understanding, the full interactions that may affect autonomous truck behaviour due to changes in various sub-systems or external environments, haul road conditions and operating performance is a key consideration. This is as true in autonomous as well as in conventional mine truck-based hauling systems where the mine haul road network is a critical and vital component of the production process."

Jan 1, 2015

By W. F. Durfee

In the year 1862 the author of this paper was called upon to design and superintend the erection and working of the machinery of an experimental works for the production of steel by a process

Jan 1, 1884