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By Peter J. Barnard

Mitochondria play a key role in the regulation of apoptosis (cell death) and in diseases characterised by abnormal apoptotic responses such as cancer. Mitochondrial membrane permeabilisation (MMP), regulated by the mitochondrial permeability transition pore complex, is widely accepted as being central to the process of cell death. As a result there has been considerable recent interest in targeting mitochondrial cell death pathways in the development of new chemotherapeutic agents.(1) There is potential to overcome the two overriding problems in cancer chemotherapy?the common occurrence of drug-resistant tumour cells and the lack of selectivity of cancer drugs in differentiating between tumour cells and normal tissues. Significantly, carcinoma cells have an elevated mitochondrial membrane potential relative to normal cells and lipophilic cations are concentrated within mitochondria in response to mitochondrial membrane potentials. There is potential for the selective targeting to tumour cells with compounds having optimal lipophilic-hydrophilic character. Research stemming from the early 1980?s points to two distinct classes of Au(I) phosphine antitumour agents where an antimitochondrial mode of action has been implicated: (i) neutral linear two-coordinate Au(I) complexes such as triethylphosphinegold(I) chloride and the tetraacetylthioglucose gold(I) phosphine complex, Auranofin; (ii) cationic tetrahedral bis-chelated Au(I) phosphine complexes related to [Au(dppe)2]+.(2) Recently it has been reported that Auranofin, at submicromolar concentrations, induces MMP observed as mitochondrial swelling and dissipation of membrane potential.(3, 4) Both events are completely inhibited by cyclosporin-A, the specific inhibitor of MMP. The permeability changes were shown to occur at concentrations associated with the selective inhibition of mitochondrial thioredoxin reductase.(3) Auranofin is a potent and specific inhibitor of this enzyme due to Au(I) binding to the active-site selenol group.(5) The redox state of mitochondrial thiols may be critical in the control of MMP.(3) In general, swelling is stimulated by thiol blocking or oxidising agents and is prevented by thiol reducing agents.(1) Mitochondrial thioredoxin reductase may play an import role in the redox control of the permeability of mitochondrial membranes.(3) Our interest is in investigating the antitumour potential of Au(I) phosphine compounds using a number of different approaches. In recent work we have evaluated a series of hydrophilic analogs of [Au(dppe)2]+ containing pyridylphosphine ligands which have demonstrated greater tumour selectivity than the parent compound. To investigate the possible antimitochondrial mode of action we are studying the effect of [Au(dppe)2]+ and related compounds on isolated rat liver mitochondria. To assess whether the lipophiliccationic nature of the compounds determines the antitumour activity, we have synthesized a series of novel Au(I) complexes based on heterocyclic carbene rather than phosphine ligands. The similar chemistry and structural features of the two classes of complexes allow us to assess whether the phosphine ligands are essential for the antitumour properties.

Oct 1, 2003

By Jeremy D. Glennon

A number of exciting challenges, opportunities and unanswered questions remain concerning the chemistry, geochemistry, medical, industrial and analytical applications of gold and its compounds.1 Among the challenges presented is the need for extraction methods for gold, at process and indeed analytical scales, that avoid the use of organic solvents or hazardous reagents. Extensive environmental contamination has occurred in the Brazilian Amazon from the mercury-gold amalgamation process. Major problems with the cyanidation process are the relatively slow dissolution kinetics and the health and environmental problems associated with it. With innovation and technical changes, a cleaner way for solubilising and extracting this versatile precious metal can be found. This cleaner future may lie in supercritical fluid science. Interestingly, geochemical studies of gold solubility and speciation in hydrothermal solutions have highlighted the importance of supercritical conditions and sulphur species in the deposition of gold in natural environments. Gold solubility in supercritical brines is far higher than previously supposed while interest in the high content of carbon dioxide in the mineralizing fluids is growing. 2,3 In recent years, also, there has been a tremendous amount of attention paid in analytical chemistry and in industry, to the area of supercritical fluid extraction (SFE) of organic and metallic species. 4 This interest has been fuelled by the introduction of more stringent environmental control and the subsequent need for cleaner solvents and processes to replace established ones. Carbon dioxide is the substance of choice for SFE because of its moderate critical parameters (Tc = 31oC, Pc = 73atm), inertness and availability in pure form. It is an excellent extraction medium for non-polar and moderately polar species, and with careful ligand design, it can be used for analytical and process scale metal extraction from solution and solid phases. In general, the dissolution of a metal in supercritical CO2 (sc-CO2) requires that the charge on the metal ion be neutralised on complexation by the ligand or through a form of ion pairing (analogous to the situation where metal ions are extracted into organic solvents, such as methyl isobutyl ketone or toluene). In this way, then, many chelating agents such as dithiocarbamates and hydroxamic acids have been utilised to extract metal ions such as Cu and Fe into sc- CO2, the process greatly enhanced by the use of fluorinated ligand derivatives. 5-7 In this review paper, we show that supercritical conditions and complexation with sulphur donor atoms, important in the natural deposition of gold, can form the basis of a clean, eco-friendly chemistry for gold extraction. Analytical scale extractions of gold from a variety of matrices can be conveniently used to assess the efficiency of any new proposed ligand.

Oct 1, 2003

By J. A. Finch

Solvent-coated air bubbles in the Air-Assisted Solvent Extraction (AASX) process achieve the dual role of high solvent specific surface area and ease of phase separation. The thickness of the solvent film is of fundamental interest but difficult to measure directly in the process itself. As an approach interferometry (in the UV-vis region) was used to measure the time dependent thickness of a film formed by blowing an air bubble in kerosene-based solvents. The film was stabilized by the presence of 1.5 ppm silicone oil, as employed in AASX. The film appears to comprise two layers; an outer "free" layer of almost constant thickness and an inner "bound" layer which decreased in thickness with time. The bound layer is considered relevant to AASX. For a 20 mm diameter bubble blown in LIX/kerosene solvent the initial thickness was ~ 3 um which decreased over 10 minutes to a final rupture thickness of 500 nm. The bound layer thickness and time to rupture decreased with decreasing bubble size. Correspondence to prior indirect estimates of solvent layer thickness is examined.

Jan 1, 2006

TIPS FOR SUCCESSFUL WASTE MANAGEMENT ? WASTE MANAGEMENT PLANS ? Define the question to be asked in waste characterization studies ? Calibrate assessments and designs with field conditions ? Ensure consistent with short, medium and long-term mine plans ? Design robust plans - goalposts and expectations will change ? Fully assess and integrate costs into economic models ? Integrate waste specialists into the feasibility and design teams ? Keep it simple and when you can?t, communicate it in simple terms ? PLAN EXECUTION ? Integrate the waste management plan into daily mine operations ? Identify the critical KPI?s , track them and set clear action triggers ? Know the difference between knowledge and data ?make sure you retain knowledge and document the important Maintain management, engineering and operational focus through the mine life

May 1, 2010

By Ahmad Ghahremaninezhad, Noelene Ahern, Yeonuk Choi

Arsenic (As) is a toxic element and is a major contaminant in the extraction processes of some metals (e.g. gold and copper). Due to the toxicity of arsenic species, its removal from As-containing streams from extractive metallurgy processes and safe disposal is absolutely necessary. For nearly complete removal of waste arsenic species from metallurgical process streams, it is required to have arsenic in its pentavalent state (As5+ species). This study presents an oxidation process for arsenic species with air or oxygen gas as oxidant. Activated carbon (AC) or other carbon based materials are used to catalyse the oxidation reaction. Air or oxygen gas is the only consumed reagent which makes the economy of the process very attractive. The oxidation reaction can be carried out at ambient conditions (room temperature and atmospheric pressure) in less than 24 hours.

Jan 1, 2014

By G. Dodbiba, A. Otsuki, T. Fujita, J. Ponou, A. Shibayama

"The different types of nano to submicron particles, which are well-dispersed nano particles, coagulated nano particles or settled submicron particles, have been measured by the interactive force apparatus (IFA). The information is very useful for mineral processing treatment. The IFA can measure the particle size distribution in low to high concentration of particles in liquids and non-light transparent liquids. Here, mainly the emulsion and bubble size measurements are described.Emulsion (w/o type) is prepared with oil and water mixture. The nano to micro emulsion particle size is usually measured by light scattering method. The particle size distribution of emulsion of light oil measured by IFA agreed well with the one by the dynamic light scattering (DLS) method. The water size distribution in emulsions of gasoline is difficult for the small reflection index and C heavy oil is difficult for the black color by DLS method. The IFA can measure both emulsions.There are many methods to measure fine air bubbles, however, the finer nano size measurement apparatuses are DLS method and IFA. A “ghost” peak appeared in the large particle micron meter size in DLS method. The mean diameter in IFA is similar with DLS for the nano meter size. INTRODUCTIONParticle size distribution measurement of nano to submicron particle, emulsion and bubble size distribution are very useful for ultrafine particle separation and characterization of fine particles by the necessity of recent fine minerals separation (For example, Li et al.2016, Mikhlin et al.2016, Wang et al.2013). As for the size measurement of solid particles in liquids, three different types of nano to submicron particles, that are well-dispersed nano particles, coagulated nano particles or settled submicron particles, have been measured by the interactive force apparatus (IFA). The particle size distributions are compared with the one of dried particles measured by TEM or SEM. The well-dispersed nano particle size distribution by IFA is influenced by the nano size surfactant micelles and becomes smaller, when compared with the TEM result. The size distribution of nano size of magnetite particles in water is influenced by the isoelectric point and the mean diameter of coagulation becomes larger. The particle coagulation in diluted suspension is about 2nm smaller when compared with the higher concentration. The submicron nickel particle size distribution is well agreed the result by SEM. The coagulation effect is small in the submicron size of nickel powder in water (Fujita et al., 2013). In this paper, the emulsion and bubble size measurements are mainly described."

Jan 1, 2016

By Yugo Mitani, Tatsuya Kato, Chiharu Tokoro, Abdullah Al Mamun

Acid mine drainage (AMD), which is a major source of mining pollution, often contains ferric and/or ferrous ions together with several toxic elements. The ferric and ferrous ions in AMD precipitate in several mineralogical forms after neutralization, and the ferric/ferrous precipitates become the main component of the sludge generated after AMD treatment. The precipitates are also good absorbents for several toxic elements. To avoid generation of voluminous sludges and the re-dissolution of toxic elements from the sludge, it is very important to generate well-draining and efficiently adsorbing sludges by controlling the mineralogical form of the ferric/ferrous precipitates. Green rust, which is ferric and ferrous hydroxide, is a double layer hydroxide which is able to sorb several toxic elements. The green rust transforms to goethite or lepidocrocite by rapid oxidation, whereas it transforms to magnetite at ambient temperature by slow oxidation. The magnetite is also good absorbent especially for toxic cations and it makes a compact sludge due to its magnetic properties. We investigated the magnetite generation process at ambient temperature in detail. The magnetite generation process can be divided into three steps; (i) oxidation of Fe(II), (ii) Fe(II) surface complexation to Fe(III) hydroxide, and (iii) crystallization of magnetite. More magnetite can form when the oxidation rate is slower than the crystallization rate, and optimum conditions for its formation are at pH 9.5 with mild agitation. Ferrihydrite is the most common precipitate and it is able to sorb many different toxic elements. However, it drains badly and its solid/liquid separation properties are poor. We investigated the removal mechanism of several toxic elements by co-precipitation with ferrihydrite. We confirmed that the removal mechanism by co-precipitation partly involved surface precipitation when the initial ratio of toxic elements to ferric ion was high, although the main mechanism was always surface complexation. When surface precipitation occurred, highly efficient toxic element removal with ferrihydrite could be achieved.

Jan 1, 2016

By Pierre Laliberté

Introduction ??Mine ventilation is a major consumer of power in underground mining, including air heating (winter) and air conditioning (deep mines). ??Any advances, including the development of low emission vehicles, that can improve underground air quality can reduce ventilation demand, and likewise reduce costs and energy consumption, including their associated greenhouse gas emissions.

Nov 1, 2011

By Marko Lampi, Ross Andrews, Jouni Pihlasalo, Robert Matusewicz

With widespread discussion on reducing carbon, sulphur and other emissions, use of sustainable energy sources and the pivotal circular economy theme, consideration needs to be given to pyrometallurgical operations broadly and more specifically, non-ferrous metallurgy. These themes present a number of challenges in terms of current operations and the view of processing the metals which are largely taken for granted in day to day living. This paper considers how these themes will impact pyrometallurgical flowsheets using the non-ferrous base metals as an example. It will examine the flowsheet chain to offer views on the boundaries of flowsheet optimization and the application of available tools to meet these future goals and challenges. INTRODUCTION The themes of reducing footprint through lowered CO2, S and other emissions, together with process sustainability (e.g. lowered energy) and links to the circular economy are well known to everyone in the metals industries. Whether it is reducing greenhouse gas emissions or analysing the importance of metals recycling in the circular economy, all these themes carry with them the fundamental premise of any change being considered; how can you best optimize a system to meet your aims? Of course, this depends on the available tools and the approach used for optimisation.

Jan 1, 2019

By G. Barbery, P. Dauphin

"In order to obtain reproducible and reproducible results in batch flotation, researchers have tried various approaches, from normalized testing, to modifying existing cells, and even designing new machines. The paper reviews the basic concepts that must be fulfilled in a laboratory flotation machine, and present the FLOTOMATEC design, which results from five years of testing and development. In addition to providing accurate measurements of air flowrate, power consumption, agitation speed, the cell eliminates most operator induced errors. Results of experiments comparing FLOTOMATEC to a conventional cell, as well as reproducibility tests are given. Introduction The use of batch flotation machines in mineral processing research and development is very common. These machines have been used for many years without almost any change in their design, instrumentation or automation. Various authors since Raffinot (1960) have criticized the available designs, especially with respect to the large errors that are introduced by the manual mode of operation. Barbery et al. (1986) have presented a review of the problems involved in laboratory testing in flotation research.Batch laboratory machines should have the following characteristics:"

Jan 1, 1989

By Dwayne D. Tannant

Digital photogrammetry allows rapid, remote measurement of millions of points, thus providing an unprecedented amount of spatial information. Research is being conducted to explore practical applications of digital photogrammetry for monitoring, surveying and mapping in surface mines. The performance, accuracy and operational ease of digital photogrammetry are discussed and practical aspects of conducting digital photogrammetry surveys are reviewed. Case histories from coal, diamond and limestone mines are presented.

May 1, 2006

? Introduction ? Partenariat MRNF - MAE ? Goldex ? Manitou : - Ré-aménagement du bassin versant - Accès aux zones problématiques - Filtration du ruisseau pour les travaux - Nettoyage près de la rivière - Régulation du débit et bassin - Digues et bassins - Déposition résidus Goldex ? Chemins d?accès Goldex-Manitou ? Pipelines: Goldex ? Retour Goldex ? Manitou ? Station de pompage ? Résumé

Feb 1, 2008

By Timothy W. Ellis

Gold-based materials have been a mainstay of the electronics and semiconductor industry since the physics was just a laboratory curiosity. Gold is the workhorse material in wire bond, flip chip and off wafer interconnections due to its corrosion resistance, ability to form metallurgical bonds by soldering or cold welding, and ease of fabrication. As the electronics and semiconductor industries grew, so did the use, of Gold in spite of the feature size reduction so elegantly demonstrated in Moore?s law. However, several revolutions in the Silicon miracle are threatening Gold?s place as the material of choice. Although cost is always an issue, the limitations are associated with the chemistry of Gold based alloys. Will Gold remain? Emerging requirements of bioelectronics, photonics and power requirements in conventional device represent new opportunities for Gold to shine. Additionally, as the world market demand for electronic, semiconducting, bio-electronic and photonic technology increases, given the right technology, Gold still can provide value proposition.

Oct 1, 2003

By S. Suzuki, C. Tokoro, S. Owada, T. Sakakibara

Acid mine drainage (AMD) has been actively treated by neutralization from about 80 abandoned or closed mines in Japan. More efficient and cost effective treatment processes has been demanded for AMD due to the government investment of billions of yen every year to protect the environment from these discharges. In this study, quantitative modeling was conducted for actual AMD to predict pH or residual concentration of toxic elements after neutralization/co-precipitation process. Simple chemical equilibrium calculation was not adequate for quantitative prediction of pH after neutralization, because residual concentration of major elements of AMD, such as Fe or Si, could not be quantitatively calculated. When oxidation rate of Fe(II) to Fe(III) and precipitation rate of kaolinite were added to the model, quantitative prediction of pH and Fe or Si concentration was achieved. Surface complexation at the interface between hydroxide such as ferrihydrite or aluminum hydroxide and AMD was the most important mechanism for removal of dilute toxic ions. When surface complexation model at the interface of ferrihydrite was added to the model, residual As (V) and Pb (II) concentration after neutralization/coprecipitation process was successfully calculated. On the other hand, surface complezation model of aluminum hydroxide was also necessary for quantitative prediction of residual Zn(II) concentration after neutralization/co-precipitation process.

Jan 1, 2014

By Y. Wong

The quality and quantity of secondary deposits, which include tailings streams and tailings dams, are increasing around the globe. The tailings are already mined, available and liberated to such an extent that the recovery of a valuable product is highly economical in terms of CAPEX & OPEX. The most widely used process for the recovery of these valuable ultra-fine haematite iron particles is the Wet High Intensity Magnetic Separation technique, originally developed by Dr. Jones over 55 years ago. Many of the original machines are still working today. The aim of this paper is to demonstrate the capabilities in terms of grade and yield of using sophisticated magnetic separation modules. All results and figures are obtained from test works, design- and engineering works. Two types of tailings have been identified for processing. Firstly, tailings that have already been deposited in a Tailings Storage Facility, and secondly, live tailings streams from an existing wet iron ore beneficiation plant. In both cases, the technical and practical results are shown along with relevant flow sheets and plant layouts. Finally, this paper highlights the total predicted power- and water consumptions, capital requirements and projected operating expenses. The results show that the operating costs are significantly lower than the mining and processing operations which are required for an equivalent amount of iron ore. The recovery % of iron depends on various factors but is within the 30–50% range, at an equivalent grade to the mainstream product. Another significant benefit is that the magnetic separation process is water positive, meaning that water is released rather than added in the process. The processing of secondary deposits will therefore result in an overall reduction in operating costs, an increase in product yield from a plant, extend the mine life and offer environmental benefits by reducing the tailings footprint and water usage.

Jan 1, 2016

By Charle Lawrence, Murray E. Blanchard

"A significant addition to Canada's commodity export transportation capabilities is being built by Ridley Terminals Inc. on Ridley Island in the Port of Prince Rupert on British Columbia's north coast.Site preparation began in early 1982. By the end of 1983 the terminal will be receiving coal from two major new mines being developed in B. C.'s massive $2.5 billion northeast coal development.The RTI terminal will have initial capacity to transfer 12 million tonnes of coal a year from railcars to storage and to ships. Capacity will be doubled to 24 million tonnes as market opportunities are developed.The challenge of building this $220-million facility in less than 24 months, the benefits Canada has received from the work the project is generating, and the long-term faith in Canada that this project represents, are all part of the excitement which surrounds the Ridley Terminal and northeast coal developments.RIDLEY TERMINALS INC. (RTI) is building a very significant addition to Canada's commodity export transportation capabilities. The facility, on Ridley Island at Prince Rupert, on the north coast of British Columbia, is a key link in British Columbia's northeast coal development which in itself is a massive undertaking involving investment of some $2.5 billion. The entire project is making a substantial contribution to Canada's economy at a time when such contributions are sorely needed.The development is creating employment, not only in British Columbia where its various parts are being created by mining companies, railways and others, but also across the country where suppliers are manufacturing a wide variety of good s and equipment for the development's participants.The RTI terminal is no exception. It is a critical cog in this mega project's large transportation system and its construction is contributing substantially to job creation and to other economic activity, in the Prince Rupert area and in many other parts of British Columbia and the rest of Canada."

Jan 1, 1983

By M. U. Oko

"Monitoring of all the waste streams from Falconbridge's Sudbury Operations to determine whether they meet the required standards, has been performed for many years. By 1969, however, the number of samples being collected had become so large that a complete revision of the existing systemwas necessary. Sites previously designated by name only, were numbered, clearly marked on the ground and on maps which were circulated to all concerned. The types of pollutants analyzed were determined and specified for each sampling location and a chemical analysis report form was designed. The sampling schedule has been computerized to produce a periodic listing of the samples to be taken and the analyses required.An area map showing sampling sites, chemical analysis report form, spill report and a computer print-out example are shown and explained.EVOLUTION OF FALCONBRIDGE'S WASTEWATER. MANAGMENT SYSTEMFalconbridge Nickel Mines employs some 4500 people, operates nine mines, four mills and a smelter in the Sudbury basin. The operations are geographically fragmented into four widely separated locations, the Falconbridge operations east of Sudbury and the Onaping operations in Levack Township being the two largest of the four. The Lockerby area located to the west and the Lindsley Mine just north of Sudbury are now under development. The magnitude, the diversity and nature of the operations are such that constant vigilance is needed to prevent inadvertent damage to the environment. The purpose of this paper is to describe the information system used to monitor and control waste-water disposal on Falconbridge's properties to help ensure the maintenance of effluent standards satisfactory to the Ontario Water Resources Commission (OWRC) and to the Ontario Department of Health."

Jan 1, 1971

By C. Bourgoin

"The limited development and application of new technologies to narrow-vein mining is currently impeding progress in the industry to a point where productivity, working conditions and operating costs have reached a critical stage in many Canadian mines.In an effort to foster the emergence and application of new technologies, Université Laval, together with other organizations, has carried out a R&D project focussed on the need of identifying new development pos5ibilities and of facilitating the transfer of technology in matters related to underground mining methods and machinery.The first phase of the study consisted of an in-depth assessment of current practices and problems in narrow-vein mining. The second phase was a state-of-the-art survey of mining methods and equipment, together with proposed modifications and innovations. The third phase of the project concerns the experimental development as well as the principal application of various proposed technologies.This paper presents an overview of the organizational, technical and strategic considerations which guided the University group and it serves as well to introduce a newly-published brochure, entitled ""Underground Mining Techniques of Vein Deposits"", which summarizes such work to date. More specifically, a perspective of technological developments applicable to narrow-vein mining is presented."

Jan 1, 1994

By R. S. Adhikari

This paper presents an innovative computer vision method for condition assessments of bridges with multiple defects in bridge elements using digital images. This work utilizes 3D model of existing bridges and overlays digital images on 3D model to simulate on-site visual inspection. The analysis of element condition index (ECI) of bridges requires information about the severity and extent of defects in elements. In general, ECI is evaluated manually during routine bridge inspection considering the severity of dominant defects. The evaluation of ECI with multiple defects needs to be addressed with consideration of dominant defect as well as the interaction among defects. However, Image-based quantification techniques largely depend on geometry of objects (i.e. shapes). Shape vectors of a given object change as they are translated, rotated, and scaled with different magnitudes. This work considers shape preserving algorithms such as, affine and projective transformation for proper image alignment. Semi-automated approach for detection and quantification of concrete distress such as cracks and spalling are considered for the defects analysis. The proposed methodology ensures the consistency in reporting ECI and eliminates the shortcoming of traditional approaches.

Aug 1, 2013

By A. R. Barnes, R. Pandher, T. Shannon, P. Gover

Following the closure of the Glencore Zinc Brunswick mine, the Glencore Brunswick Smelter has transitioned to treating external feeds, and currently treats a number of secondary Pb-Zn concentrates. Processing these concentrates has in some cases been challenging due to the diverse mineralogy of the feeds. Certain feeds are difficult to ignite or show inadequate sulphur removal during oxidation on the sinter strand, while in other cases, combinations of feeds produce a sinter with unsuitable properties for further handling. This paper discusses two methods developed in collaboration with XPS Consulting & Testwork Services to characterize these feeds prior to processing them and to identify which ones are most likely to pose challenges during processing.

Jan 1, 2014