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By N. Parnian

"Carryover of caustic soda (NaOH) in the steam path caused catastrophic failure of superheater 304H stainless steel tubes in a steam generator and led to an unexpected shutdown after just five months of continuous service of petrochemical following the start of production. The cause of the failure was studied, with a focus on the formation of sigma phase in the weld joint and effect of caustic embrittlement on stress corrosion cracking (SCC). The cracks were examined at the seam weld, heat affected zone (HAZ), and Ubend areas. Hardness was measured for the base metal, HAZ, and weld metal, and microstructures were examined using optical microscopy and scanning electron microscopy (SEM). Crack initiation is attributed to gouging on the precipitated carbide at the HAZ and also the formation of sigma phase in the weld metal, as shown by energy dispersive X-ray (EDX) analysis. In addition, cracking was propagated by caustic embrittlement because of residual stresses and hammering. Finally, the characteristic feature of fracture was illustrated by SEM fractography, and consists mostly of intergranular SCC and some quasicleavage transgranular. INTRODUCTIONThree key factors are needed for the initiation and propagation of intergranular stress corrosion cracking (IGSCC): a susceptible material, a corrosive environment, and sufficient stress. Although austenitic stainless steels are susceptible to sensitization and IGSCC, they are widely used in boiler and superheater tubes because of their high corrosion resistance, high oxidation resistance, acceptable mechanical characteristics at elevated temperatures, and low cost.Sodium hydroxide is injected to neutralize acidic constituents in the steam path, but caustic can concentrate in boiler tubes and attack the surface metal (known as gouging) even traces of caustic in the steam can deposit on surfaces and cause local concentrations of several percent (ASM handbook, 1992). Not only sensitized grains but also sigma phase formed in the weld metal can initiate caustic cracking. In this research, the cause of the failure of 304H stainless steel superheater tubes in a methanol petrochemical plant in Iran was studied with a focus on the effects of caustic embrittlement on IGSCC."

Jan 1, 2012

By Cleber Caetano Thomazi

Rotary kilns are continuous process equipment used on calcining of nickel ore. The chemical and physical reactions are created by means of heat up the material to predetermined temperatures. Tertiary air fans are attached to the kiln shell to maintain oxidizing/reduction conditions. Special ducts orientate the air flow inside the kiln. In the present work, two types of failure on distinct tertiary ducts mounted on the same kiln are reported. Chemical analysis, hardness test, metallographic and fractographic examinations were carried out. Fabrication related problems and creep were identified as the root causes of damages.

Oct 30, 2017

By J. Paraszczak

High productivity of the equipment employed is one of the key factors in reducing production cost in mining. One of the best ways to achieve it is an increase in availability. In order to identify the most adverse factors affecting it, reliability and maintainability analysis ought to be done. If its results are to be conclusive, a sufficient amount of credible and consistent data is indispensable. Following the experience from field studies done in underground mines, this paper discusses the current status of failure and maintenance reporting, as well as problems encountered. It exposes the importance of adequate data collection on failures and downtime as well as it reviews the benefits of analysis based on such material. The question of benchmarking with regards to mining equipment performance is also addressed. The paper concludes with some recommendations on data collection and processing, as well as stresses the need to standardize the most important reliability/ maintenance notions throughout the mining industry and to conceive appropriate performance measures.

Jan 1, 2000

Coal mining legislation makes frequent reference to æSafety Management SystemsÆ but there is a chronic shortage of useful guidance material as to how these might be applied to hazardous exposures. Several studies have indicated that for each death that is reported as a result of an industrial æaccidentÆ, there are five deaths that caused by occupational exposures. Because the deaths from occupational exposures do not occur on site and often well after employment has ceased, they are generally unreported. Improved access to mortality data from coroners, the Australian Institute of Health and Welfare and superannuation service providers (early claims from death and total permanent disability), has given rise to some analysis of death and disability data that provides evidence that there are emerging opportunities to develop and improve safety management systems for hazardous occupational exposures. Issues explored include how safety management systems might be developed in relation to dusts and chemicals and other hazardous exposures to ensure the risk of disorders with long latency periods are reliably assessed and the exposures effectively managed. The current standards and guidelines which refer to safety management systems in general or to management of exposure related hazards are examined. Many standards are based on dose-response studies that provide for an acceptable percentage of workers to suffer adverse health outcomes. An alternative management system might be to apply dose-response relations to health surveillance to identify æat riskÆ individuals and effectively manage health and related safety risk at an early stage.

Jan 1, 2005

By James E. Rider

"Fractures in mine hoist drumshafts are rare. We know of no previously reported attempts to repair a fractured drumshaft; any feasible method would involve welding and the associated problems of distortion, crack formation and strength.In June 1984, a fracture was discovered in the drumshaft of the production hoist in the Teck Corporation, Lamaque Division Mine at Val d'Or, Quebec. Delivery time on a new shaft would have been at least six months. The shaft was repaired in ten days and the total out -of-service time was four weeks.This paper describes why the shaft failed, how it was repaired, and the special alignment procedures employed during re-installation to minimize stresses in the repaired area.IntroductionThe performance of a mine hoist drumshaft is absolutely critical to mine operation. An inoperable drumshaft means no hoist, which in turn means no production or mine operation.Fractures in mine hoist drumshafts are rare. Previously when they have occurred, no one has seriously considered attempting a repair because of problems involved. Any feasible method would involve welding, which raises several major problems - namely, metallurgical, alignment, and strength.In July 1984 this very situation occurred at the Teck Corporation, Lamaque Division Mine in Val d'Or, Quebec.It was recognized that a new shaft would take at least 6 months' fabrication and delivery time. However, having had some experience at repairing broken shafts in other machines under similarly desperate circumstances, and after due consideration, it was concluded that by applying the correct techniques and engaging the right expertise, it would be possible to perform a repair and have the mine back in operation within a month.Thanks to outstanding efforts by all, the repair was accomplished in ten days and total out-of-service-time was only four weeks. The causes of the failure were determined and the calculated stress levels confirmed by strain gauge measurement during operation.The success of this project was achieved by adhering rigorously to fundamental management and engineering principles."

Jan 1, 1988

By Ping Li, Baokun Zhou, Lei Yang, Changfeng Li, Erhui Zhang

A uniaxial compression experiment was conducted on standard sandstone specimens to explore the sandstone’s mutation characteristics and early warning interval during deformation and failure. Meanwhile, acoustic emission (AE) and digital image correlation (DIC) techniques were introduced to realize multi-field analysis and cross-validation from the stress field, deformation field, and elastic wave field. The mutation characteristics of rock failure were investigated based on the cusp catastrophe theory. The results showed four mutation points in the destabilization process of sandstone: compressional density, yielding, destruction, and residual retention. As an internal activity characteristic of the sandstone failure process, AE directly reflected the dynamic failure process of sandstone. The stress variation was closely related to the evolution of AE characteristics. Sandstone loading failure was a process of the mutations of releasable elastic strain energy, dissipative energy, and releasable elastic strain energy. The mutation of dissipative energy was used as the starting mark of the sandstone warning state, and the second mutation of releasable elastic strain energy was used as the end mark of the sandstone warning state. Besides, the warning range corresponded to the loading time of 178 to 208 s. Finally, the sandstone instability warning interval was re-determined from deformation field evolution characteristics in the sandstone damage process, with a loading time of 180–204 s. This was consistent with the warning interval specified using the cusp catastrophe theory. The combination of AE, DIC, and cusp catastrophe theory revealed the mutation characteristics and early warning interval of sandstone failure. Hence, the results provide significant importance to predicting rock failure.

Aug 23, 2023

By Anthony T. Iannachione

The location and time of 2,007 microseismic emissions from a limestone mine in southwestern Pennsylvania were compared with the development of mine faces and the characteristics of the mine layout. Based on analyses of these results, the occurrence of roof failure zones appears to be associated with certain characteristics of the mine plan. It was determined that significant relationships exist between the intensity of the microseismic activity and the scale of the roof failures. Microseismic activity associated with these roof falls occurs in distinct episodes, with the final failure event occurring during approximately a 12-hour period. Each roof fall episode appears to be composed of dozens of distinct roof beam failures. As each beam fails in shear and tension, tens to hundreds of audible noises representing rock fracturing or bedding plane separation can occur. While every roof fall can be viewed as unique, certain mechanistic similarities can be realized through careful observation and monitoring of these complex systems. Understanding these similarities in characteristics allows mine personnel to design the most effective and efficient control technique.

Jan 1, 2001

By D. C. Martin, P. M. Hawley, C. P. Acott

"In bedded deposits such as coal or sedimentary iron, economic limits of mineable reserves are clearly defined by the footwall of the seams or ore-bearing units. Where open pits are developed in dipping strata, a long, high footwall slope may result. In many cases, unbenched slopes excavated along the base of the lowest mineable seam are operationally simple, economically desirable and geotechnicalty practical, although a variety of failure mechanisms may develop. This paper examines the engineering geology and rock mechanics parameters of importance in the design of footwall slopes. Possible failure mechanisms and stability analysis methods are described. Design considerations for benched and unbenched slopes are discussed with prime consideration given to development of long high stopes without benches or with a minimum number of benches. IntroductionIn bedded deposits, the ultimate depth and economic viability of an open pit in dipping strata may be controlled by the design of the footwall slope. The stability and, hence, design of footwall slopes is strongly influenced by the engineering geology and rock mechanics parameters of the slope forming materials. A clear understanding of the structural geology, engineering geology and tectonic history of the deposit is essential to assess the behaviour of the slope. This is particularly important for long high, unbenched footwall slopes such as shown in Photo I.A rational footwall slope design requires identification and assessment of all possible slope failure mechanisms with respect to the proposed slope geometry. Stability analyses of each potential failure mechanism are used to identify the main controls on slope stability and to develop appropriate slope design criteria. The optimum slope design is based on the most economic and geotechnically practical slope geometry with due consideration of operational constraints and of the possible advantages of specific remedial measures."

Jan 1, 1986

By M. L. Jeremic, G. J. P Delaire

"The mechanical aspects of cable bolt failure are considered from the point of view of properties of grout and cable, as well as of the rock in which it is anchored. The results from recent investigations made in-situ as well as in the lab are combined and presented with reference to other work done in the area. An attempt is made to stimulate the thinking along these lines so as to initiate further research which may enhance the design of cable bolting as it applied to mining operations.IntroductionIn the past twelve year s systematic cable bolting has found application in many areas. In civil engineering rock anchors have been used to provide tension at the heel of a dam permitting the reduction of its cross section. They have been used in retaining walls to reduce construction time and costs by eliminating the need for struts and braces which complicate pouring the foundation walls. It is also possible to use rock anchors in providing reactions where tall buildings are subjected to uplift on one side due to wind forces. Cantilever bridges may be constructed by implementing rock anchors to provide anchorage requirements. Anchorage piles or dolphins or mooring ships have also been built using these. In the mining area rock anchors, commonly known as cable bolts because they are made of hoist cable may be implemented in the reinforcement of hanging walls or to retain rock slopes.In order to sustain de-pressurized ground where rock separation developed along the pressure arches, cable bolts were utilized at the Tsumeb Mine in South-West Africa and also at the Strathcona Mine in Sudbury, Ontario, In both places old degreased hoist ropes were installed in downholes from crosscuts above a given stope and then grouted without tensioning. Jeremic and Cassidy described the use of cable bolts to increase hanging wall stability and postpone fracturing, in addition to producing pre-support for improvement of stope back stability."

Jan 1, 1983

By R. Karl Zipf

Multiple seam mining interactions caused by full extraction mining, whether due to undermining or overmining, frequently involve tensile failure of the affected mine roof. The adverse ground control conditions may prevent mining for both safety and economic reasons. Prior researchers have identified the geometric, geologic and mining factors controlling multiple seam mining interactions. This numerical study examines the mechanics of these interactions using a modeling procedure that 1) incorporates the essential constitutive behavior of the rock such as strain-softening of the intact rock and shear and tensile failure along bedding planes and 2) captures the geologic variability of the rock especially the layering of weak and strong rocks and weak bedding planes. Specifically, the numerical study considered the effect of vertical stress, interburden thickness, and the immediate roof quality of the affected seam in both undermining and overmining situations. The models show that for overburden-to-interburden thickness (OB/IB) ratios of less than 5, interactions do not occur, and that for OB/IB more than 50, extreme interaction is a certainty. In between, the possibility of an interaction was found to depend on gob width-to-interburden thickness ratio, site specific geology and horizontal stress to rock strength ratio in addition to the OB/IB ratio. The models also showed that horizontal stress was profoundly altered well above or below a full extraction area and that these changes are likely to influence the success or failure of multiple seam mining. The role of horizontal stress in multiple seam mining interactions has received little attention in prior investigations. Four factors control the mechanics of multiple seam mining interactions: 1. vertical stress concentration 2. horizontal stress concentration 3. stress re-direction 4. bedding plane slip bands A combination of vertical and horizontal stress increase and high stress gradients in the vicinity of full extraction areas re-orients principal stresses into a very unfavorable direction. This seemingly small stress re-orientation has a profound adverse effect on bedded rock.

By R. Karl Zipf

Multiple seam mining interactions caused by full extraction mining, whether due to undermining or overmining, frequently involve tensile failure of the affected mine roof. The adverse ground control conditions may prevent mining for both safety and economic reasons. Prior researchers have identified the geometric, geologic and mining factors controlling multiple seam mining interactions. This numerical study examines the mechanics of these interactions using a modeling procedure that 1) incorporates the essential constitutive behavior of the rock such as strain- softening of the intact rock and shear and tensile failure along bedding planes and 2) captures the geologic variability of the rock especially the layering of weak and strong rocks and weak bedding planes. Specifically, the numerical study considered the effect of vertical stress, interburden thickness, and the immediate roof quality of the affected seam in both undermining and overmining situations. The models show that for overburden-to-interburden thickness (OBAB) ratios of less than 5, interactions do not occur, and that for OBAB more than 50, extreme interaction is a certainty. In between, the possibility of an interaction was found to depend on gob width-to-interburden thickness ratio, site specific geology and horizontal stress to rock strength ratio in addition to the OBIIB ratio. The models also showed that horizontal stress was profoundly altered well above or below a full extraction area and that these changes are likely to influence the success or failure of multiple seam mining. The role of horizontal stress in multiple seam mining interactions has received little attention in prior investigations. Four factors control the mechanics of multiple seam mining interactions: 1. vertical stress concentration 2. horizontal stress concentration 3. stress re-direction 4. bedding plane slip bands A combination of vertical and horizontal stress increase and high stress gradients in the vicinity of full extraction areas re-orients principal stresses into a very unfavorable direction. This seemingly small stress re-orientation has a profound adverse effect on bedded rock.

Jan 1, 2005

By Meng Wang

"In this study, multiple methods that include geological surveying, laboratory studies, and numerical modeling have been used to study the deformation characteristics of a “deep inclined rock roadway with weak planes” (DIRRWP). Failure of the DIRRWP was found to be triggered initially by the shearing of the rock near the weak plane. The movement of the failed rock resulted in reduced confinement of the deeper rocks, and causing the failure of the supporting units and the severe deformation of the surrounding rocks. Hence, it is concluded that DIRRWP stability is affected predominantly by rocks near the weak plane. Corresponding control strategies for DIRRWP deformation were proposed: (1) greater support intensity is necessary to maintain the stability of the whole DIRRWP; (2) additional support is needed for rocks near the weak plane to reduce the potential of failure; (3) to increase the bearing capacity of the floor strata, as the floor needs to be supported; and (4) a supplementary support technique should be considered for cases of large deformation. The case study presented here indicates that the proposed control strategies can significantly reduce the potential of failure in rocks near the weak plane, thus preventing severe deformation of the DIRRWP.INTRODUCTIONAs shallow seams are mined out, the cover depths in most Chinese coalmines have become increasingly greater. Deep cover in a coalmine is considered to occur when the cover depth exceeds 800 m (Sun, Chen, and Miao, 2018). The loading and failure behavior of rocks in a deep cover setting are quite different from those in a shallow cover setting owing to the increase in in-situ stress, temperature, and hyperosmosis (Lobanova, 2008; Zhang et al., 2013). For instance, experience shows that bulking and dilating deformation in deep roadways is much greater than that which occurs in shallow roadways (Hou and Yang, 2018; Zhang et al., 2016). In addition, anisotropic behavior and thickness deviation of coal measure rocks, combined with the appearance of weak planes (e.g., faults, joints, and coal cleats) in coal and/or rocks, can significantly affect the stability of an underground roadway (Ghazvinian et al., 2013; Sun, Chen, and Miao, 2018). The presence of weak planes can significantly complicate displacement and stress transmission in nearby rocks. Additionally, tensile, compressive, and/or shearing failure in rocks near weak planes can be easily caused by high in-situ stresses in deep roadways; such failures may lead to further severe deformation of the surrounding rocks, resulting in roof falls and rib spalling (Kamata and Mashimo 2001; Wu, Ohnishi, and Nishiyama, 2004). A typical failure of the so-called “deep inclined rock roadway with weak planes” (DIRRWP) is shown in Figure 1. Severe deformation can be found near the weak plane. In this study, a plane or thin layer of rock/coal parting that can significantly reduce the strength of the surrounding rocks—and thus affect roadway stability—is defined as the weak plane."

Jan 1, 2019

By H. R. Shakeri, R. Mayer, M. J. Worswick, A. Rahem

The current focus of research and development in transportation industry is to use lightweight materials such as aluminium alloys for more structural components. In this regard, maintaining safety of the passenger and vehicle is the most important; therefore crashworthiness of components made of lightweight materials must be evaluated prior to sizable application of these materials. The focus of the present study is to understand failure and damage mechanisms during the axial crushing of aluminium tubes made of A1Mg3.5Mn alloy of 2 and 3.5 mm thickness. Due mainly to complexity of the crushed tubes, a microstructural approach is considered. In this study optical, stereo as well as scanning electron microscopy techniques have been used to study damage and failure mechanisms in these types of tubes, which are essential energy absorbing components in passenger vehicles.

Jan 1, 2006

By E. O. Abrokwah

Directionally solidified (DS) Rene 80 Superalloy was tested in thermo-mechanical fatigue (TMF) over the temperature range 500-900°C and plastic strain levels from 0.2 to 0.8% using a DSI Gleeble thermal simulator. Thermo-mechanical testing was carried out on the parent material in the conventional solution treated and aged condition (STA), as well as gas tungsten arc welded with an IN-738 filler, followed by solution treatment and ageing. Comparison of the base TMF unwelded alloy with that of the welded and heat treated alloy showed that varying crack initiation mechanisms, notably oxidation either by stress assisted grain boundary oxidation, or associated with grain boundary MC carbides fatigue crack propagation along grain boundaries and creep deformation were operating, leading to different "weakest link" failure initiation points.

Jan 1, 2011

By Yingxin Zhou

Virtually every coal seam in Appalachia will at some time be subject to multi-seam interaction (Wu et al, 1987). Many such problems result from seams which lie in close proximity or have split and lie within thirty feet vertically of one another. Existing techniques for multi- seam design have concentrated on conditions where the entire inner burden is not the failing member and are unsuitable for ultra-close multi-seam design. Structural integrity of the inner burden must be maintained if two superimposed seams are to be mined separately and under- standing possible failure mechanisms of the inner burden is an essential first step in the design process.

Jan 1, 1989

By Joseph J. Mgumbwa

Pillars are any structures left between two or more underground openings. The stability of pillars is normally considered to depend on shape (defined by width to height ratio), rock mass strength, extraction ratio, in situ stresses and the gross structural features (i.e. joints, contacts, faults etc). Recent experience has shown that pillar stability is also controlled by the relative orientation of the orebody with respect to the in situ principal stress. In inclined orebodies, pillars are loaded in compression and shear, thus creating unsymmetrical stress distribution. Failure mechanisms of these pillars are little known. This paper investigates the failure mechanisms of pillars under shear loading. Two dimensional elastic numerical modeling was used to examine the behavior of pillars in different orebody inclinations relative to the major farfield stress orientation. First, the paper reviews pillar design approaches including the empirical pillar design chart and uses numerical modeling to investigate the effect of the major farfield stress orientation on pillar stability. It is concluded that the empirical pillar design chart be used with caution, and that for orebodies under shear loading mine planning and design should take this into consideration since such geometrical orebody/stress relations put mine structures at higher risk of instability.

Oct 1, 2010

By Manasi Wijerathna, D. S. Liyanapathirana

"Deep cement mixing is a popular soft ground improving technology that improves the bearing capacity and settlement characteristics of natural soil. When Deep Cement Mixed (DCM) columns are installed attached to each other in a wall configuration, the walls are capable of resisting bending moments and shear forces in the direction transverse to the columns. Therefore, installing DCM walls beneath the embankment slope perpendicular to the alignment of the embankment is a proper solution to prevent excessive lateral deformations of the embankment. Previous research studies have shown that failure patterns of DCM column walls are different to failure patterns of individual DCM column rows, under lateral loads. This study investigates the failure patterns of embankments where DCM column walls are located beneath the slopes, with respect to DCM wall strength, DCM column wall width and the spacing between DCM walls. 2D and 3D numerical models developed using the ABAQUS/standard finite element programme, were used in this investigation. Results show that the DCM wall strength and width of the DCM wall have a significant influence on the failure mode and the critical failure surface of the embankment. 3D simulation results demonstrate that the failure due to soil extrusion between columns was less pronounced in embankments improved with DCM walls, due to the interaction between the DCM walls and the surrounding natural soil.INTRODUCTIONEmbankments constructed over soft ground are highly susceptible to global slope failure and excessive displacements due to combined effects of vertical and lateral loads beneath the embankment slope (Zheng et al., 2009, Han and Gabr, 2002). The overall stability of the embankment can be significantly improved by improving the soil beneath the slope of the embankment using Deep Cement Mixed (DCM) column rows or overlapped DCM column walls (Jamsawang et al., 2015, Larsson and Broms, 2000, Topolniki, 2004, Broms, 1999). According to the literature, the improved ground experience different failure modes other than shear failure, such as separation of columns, overturning, shear failure along the columns or dowel action (Broms, 1999). Some of the failure modes reported by Broms (1999) are shown in Fig. 1. The ultimate failure mode depends on the geometry and the strength of the improved ground (Jamsawang et al., 2015, Kitazume and Maruyama, 2006, Kitazume and Maruyama, 2007)."

Jan 1, 1900

By S. C. Bandis, N. Barton

During drilling of deep boreholes, local mechanical failures of the wellbore walls may occur due to the inability of the incompetent overburden and reservoir rocks to withstand drilling-induced changes of the stress environment. At present, borehole failure mechanisms in three-dimensional stress fields are poorly understood. Our experimental investigations based on 3-D physical models demonstrate the stabilizing effect of the intermediate principal stress. The latter may play a dominant role in maintaining the integrity of the stress relieving failure zone around the borehole. However, this will depend on the stress anisotropy, the angle of hole deviation and on the angle of internal friction. Our tests also indicate that the failure zone can accomodate high extensional strains. Finally, relations between the physical models and closed-form elasto-plastic solutions are discussed.

Jan 1, 1986

By Hui Chen

The paper describes the use of a physical model technique to investigate the failure modes of mine tunnels with reference to the in situ stress field. The characteristics of stratification commonly encountered within UK coal mining conditions have been taken into consideration. The investigation has indicated that the weak floor strata in coal mining tunnels, under the action of high rock stresses, will be subject to the floor lift problem in both predominantly horizontal and vertical stress fields. However, the failure mode and mechanism varies between the two stress field patterns. In the predominantly horizontal stress field, the tunnel floor tends to fail by gradual bending of the laminations, whilst in the predominantly vertical stress field, the floor tends to fail by a shearing action with the failed material lifting in the form of a block. The failure mechanism is discussed with reference to mechanics theory.

Jan 1, 1993

By King E. J

Department of Pathology, British Post-graduate Medical School, London:The experiments here recorded were devised and carried -out during the last two years in an attempt to corroborate the important work of Denny, Robson and Irwin (1939) in which they found that experimental silicosis could be prevented by means of metallic aluminum. By causing rabbits to inhale powdered quartz for several months they induced experimental silicosis. These animals then served as controls for comparison with another group which were dusted with a mixture of quartz and aluminum. In the second group silicosis failed to develop.Our experimental procedure was somewhat different. We resorted to intratracheal insufflation instead of simple inhalation, and we used rats instead of rabbits: otherwise the essential features of the original experiments were carefully duplicated.EXPERIMENTAL PROCEDURES.A single dose of dust was delivered into the lungs of each animal. The dust was suspended in a fluid medium and injected by means of a syringe directly into the trachea in known quantity (technique of Kettle and Hilton, 1932). The suspensions were autoclaved before use and were injected with aseptic precautions. Having had a long experience of this technique we employed it with confidence and usually secured a fairly uniform dispersal of dust throughout both lungs. To carry out injections successfully one requires, above all, an even suspension of dust which will flow smoothly and quickly from the syringe. This is not difficult in the case of quartz, for, though it tends to settle out rather quickly, this can be avoided by constantly agitating the suspension. The syringe containing the inoculum may be shaken gently right up to the moment of injection and then emptied quickly to prevent sedimentation. Powdered aluminum is more difficult to handle, for the particles tend to flocculate and are not readily made to disperse evenly in saline, even by violent shaking. For this reason an emulsifying agent may be used to advantage, provided it does not complicate the experiment, a point to be mentioned again presently.THE EXPERIMENTSExperiments with quartz alone: Extensive silicotic lesions were produced in 23 out of 26 rats by the administration of pure quartz dust in doses of from 50 to 200 mg. per rat. The dust was so finely pulverised that the particles averaged about 1-p. in size: none was larger than 5 p. and 99 per cent. were under 2.5 p.Eight of these animals survived for seven months and were then killed...

Jan 1, 1945