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By Bhavani Kedika, Venkatagiri Noole, Krishna Thotla, Krishna Reddy Chepyala

Cationic lipids are attractive candidates for transgene delivery and expression and are safer alternatives to viral delivery vehicles. Here, we report the design, synthesis, characterization and transgene expression efficacies of a series of chrysin derived cationic lipids. A series of ten lipids of chrysin was synthesized by treating the 7-hydroxy group with dibromoalkane and further substitution of the bromo derivative with alkyl amines. The synthesized lipids were characterized spectroscopically. Parallel screening of the synthesized lipids for in vitro plasmid delivery expressing luciferase led to identification of several leads that demonstrated higher transgene expression when compared to the standard. Transgene expression efficacy was dependent on the chain length of the lipid. The influence of the various physicochemical properties on transgene expression efficacies was investigated. This study indicates that lipids derived from chrysin results in high levels of transgene expression and may be attractive for gene therapy applications.

Mar 1, 2017

By Reed W. Hyde

SOME information has been published on the sulphur dioxide concentration of gases from Dwight-Lloyd machines sintering lead ores but most of this relates to the customary practice in which the charge is relatively high in lead and is sintered in two passes over the machine. It is thought, therefore, that the following observations on sintering in one pass a low-lead, low-sulphur charge may be of interest. The data were obtained in sintering lead sulphide flotation concentrates mixed with minus 20-mesh oxide ore, the mixture carrying 16.8 per cent Pb and 5.3 per cent S. No returns were used because of the limited amount of sulphur available as fuel, but the mixture pelletized readily to make a satisfactorily permeable bed on the sintering machine. As there was a possibility that the SO2 might be utilized, a series of runs was made to determine the concentration of SO2 in the gases at different points along the wind box, and the effect on this concentration of changes in the wind-box vacuum. Several runs each were made with vacuums (as measured in inches of water at the wind box) of (1) 2 to 1 3/4 in., (2) 4 to 3 1/2 in. and (3) 6 to 5 1/8 in. The averages of the determinations from each series are platted on the graph (Fig. I). The vertical scale shows the percentage by volume of SO2 (as determined by the Reich method), and the horizontal scale shows the time expressed as percentage of the total sintering time. Sintering was considered to be complete when no SO2 could be detected in the gases. In all cases the depth of bed was 4 1/2 in. and the weight of dry charge per square foot of hearth area was 45.2 lb. Other data are given in the table. The volume of gases corresponding to the several points along the wind box at which SO2 determinations were made could not be measured, but has been calculated from the SO2 content and sulphur elimination on the assumption that the volume is uniform throughout the sintering period. This is not strictly true, as with a given vacuum the volume will usually drop slightly toward the middle of the period and increase toward the end. However, this assumption is a reasonable approximation. Several interesting features are brought out by these data. In general, the published data on SO2 concentration in sintering under ordinary conditions show a high SO2 concentration in the early stages followed by a rapid decrease in concentration and with relatively little SO2 in the gases from the last half or third of the operation. In other words, the greater part of the sulphur elimination is obtained in the first third or half of the period. In these runs, the 6-in. vacuum, which approximates the usual operating condition, gives a curve that follows this customary pattern. Maximum SO2 concentration is obtained 2 ½ min. after

Jan 1, 1942

By X. Cao, P. Wanjara, J. L. Fihey, X-T. Pham, F. Mirakhorli

Single-pass hybrid laser-arc welding of 10-mm thick cast plates of CA6NM, a low carbon martensitic stainless steel, was carried out in butt joint configuration using a continuous wave fiber laser at its maximum power of 5.2 kW over welding speeds ranging from 0.75 m/min to 1.2 m/min. The microstructures from the fusion zone to the heat affected zone and base metal were characterized after post-weld tempering at 600°C for 1 hour. From optical and scanning electron microscopy examination, the fusion zone was observed to mainly consist of tempered lath martensite and some residual delta-ferrite. The mechanical properties including microindentation hardness, ultimate tensile strength and Charpy impact energy were evaluated in the post-weld tempered condition and correlated to the microstructures and defects. The ultimate tensile strength and Charpy impact energy values of all the fully penetrated welds in the tempered condition were acceptable according to ASTM, ASME and industrial specifications. The failure mechanisms during tensile deformation and Charpy impact loading were examined by scanning electron microscopy, fractography and optical metallographic analysis near the fracture origin.

Jan 1, 2015

By Giuseppe Pintaude, Carlos Mauricio Lepienski

The evaluation of the tribological behavior of thermochemically treated surfaces, such as carburising and nitriding, is of uppermost importance for the productive chain of tools, molds and matrices. However, the use of tribological tests for these surfaces should be well selected to avoid erroneous evaluations, in particular considering the effect of the substrate at different levels. In this context, the linear scratch test may be well suited to distinguish the roles of the surface and the substrate. For that purpose, this paper presents a review on the use of this type of test for tribological evaluation in terms of the performance of thermochemically treated surfaces. The approach used is multiscale, considering what types of results are obtained from each load range used and the applications for each one of them.

Nov 22, 2018

By Taufiq Hidayat

Accurate description of complex phase equilibria provide the foundations for the improvement of non-ferrous pyrometallurgical smelting and recycling processes. Recent advances in microanalysis and experimental techniques enable accurate phase equilibria characterisation. Quantitative microanalytical techniques including Electron Probe X-ray Microanalysis and Laser Ablation ICP-MS enable the concentrations of major and minor elements present in different phases in samples to be accurately measured providing data that cannot be obtained using bulk chemical analysis techniques. High-temperature equilibration experiments coupled with the subsequent analysis of elementary reactions at micro- and macro-scales ensure the attainment of equilibrium conditions, and therefore, ensure true phase equilibria information is obtained. Examples of the application of the improved methodology on the investigation of phase equilibria of low-order and complex, multi-component gas/slag/matte/metal/solids Cu2O–PbO–ZnO–Al2O3–CaO–MgO– FeO–Fe2O3–SiO2–S systems and the distribution of minor element are provided. The experimental study is closely integrated with thermodynamic database development for the above system. Example of implementation of the research outcomes into industrial operations is demonstrated.

By Vladimiros G. Papangelakis

During the past five years, chemical modelling work at the University of Toronto has elucidated the role of soluble magnesium on the autoclave acidity and has demonstrated why feeds rich in magnesium, and other divalent metals, require more than the stoichiometric requirements in acid to produce a leaching performance comparable to that of low magnesium feeds. This understanding has allowed the calculation of acid additions to the pressure acid leach (PAL) on a less empirical basis. Optimizing acid additions to the PAL confers savings in neutralization costs, ensures high productivity and minimises corrosion problems. Hence, our picture of the solution chemistry inside the autoclave during the PAL process has been substantially improved and is reviewed here. Experimental techniques based on solubility and direct acidity measurements that support the theoretical predictions are presented. Concepts of chemical modelling of electrolyte systems at high temperature and software issues are also discussed. Finally, a better understanding of the solution chemistry at temperature has led to better kinetics models because all metal dissolution and precipitation reactions are acid driven and controlled. . Therefore, reactor modelling efforts by our group are also presented and a reactor model with very good performance, as compared to pilot-plant data, is also made here. Finally, in spite of the above success in PAL solution chemistry and reactor modelling, significant challenges lie ahead in theoretical data gaps and instrumentation; these are also discussed in this paper. Keywords: Laterites, process modelling, pressure acid leach, solution chemistry, chemical modelling, reactor simulation

Jan 1, 2004

By Bo Hyun Kim, Mark K. Larson

Researchers at the National Institute for Occupational Safety and Health have tested the finite element code, UT3PC, with LaModel to evaluate their results using know case studies. The purpose of the testing was to demonstrate the usefulness and limitations of these programs in evaluating mine layout design. Both of these software packages are simple to use and free for public download. Their use by mine engineers, along with other tools, such as empirical methods, can enhance the assessment of a mine layout design. LaModel can model mining layout on a mine scale or, at least, on a multiple-panel scale. However, this software has limitations in calibrating to conditions at many coal mines in the western United States. The UT3PC software models smaller parts of a mine and is used to evaluate the design of pillars, shafts, or drifts; but the software calculates all components of the stress tensor and provides stresses, displacements, and safety factors throughout the model volume. The two codes are used to evaluate design of one known case, and UT3PC is used to evaluate another case. The results and approaches demonstrated in the testing are intended to aid mine engineers in evaluating site-specific problems and to show that these tools can provide useful information to the mine engineer in evaluating mine layout design.

Jul 1, 2023

By B Kilgariff

Flotation has been in use at Broken Hill for nearly 100 years, and the process has gone through many different optimisation studies over that time. This paper reviews the current flotation practice at the Perilya Broken Hill Mine, and details one of the recent optimisation studies conducted using mathematical modelling and simulation tools. The optimisation study consisted of surveys of the lead and zinc circuits, mapping of the floatability components of the ore and developing models of the lead and zinc circuits. The models were then used to conduct simulations to simplify the circuit. The study allowed plant personnel to identify optimum operating conditions for their current flotation cells, as well as possible improvements in circuit configuration and cell capacity.

Jan 1, 2005

By Tiruvengala Padma, Nilesh Naik

Piles are common type of deep foundation elements used for the special bridges, transmission towers, Jetties, and tall structures. Lateral loads on the structures can be due to either earth pressures, wind, waves, impact, moving vehicles and eccentric application of axial loads or in combination of the loads. Hence the lateral capacity of piles plays a major role in determining the pile dimensions. The laterally loaded pile analysis is a soil-structure interaction problem as the lateral capacity of pile depends on the soil strength and stiffness parameters and its reaction to the lateral load on pile. The common approach to determine the lateral load analysis of piles is the Beam on Lateral Springs Method also known as “p-y” method. In this method the pile is modelled as a beam and supporting soil is modelled as lateral springs. This study is focused on the comparison of output obtained from three geotechnical softwares namely FB-MultiPier, L- Pile and Wallap. L-Pile Software is based on Finite Difference Method, Wallap on Horizontal Subgrade Modulus Method and FB MultiPier on Finite Element Method. Pile response in terms of deflection, shear force and bending moments under vertical and horizontal loads from above three software are compared and concluded.

Sep 1, 2022

By Carlos Torres, Albert Cabrejo

For the last 20 years mine slopes have been monitored with slope stability radars. Since 2015 a group of dedicated geotechnical engineers dedicated to remotely monitor radars around the world have detected 2000+ slope failures of different characteristics. A statistical analysis of the information gathered of these failures have been made and the summarized results are presented with some degree of analysis appropriate for the vastness of the database. The analysis considers different types of commodities, countries, mining processes, rock types, and weather conditions.

Sep 29, 2023

By L. A. Eros

The U.S. Bureau of Mines and Western Fuels Utah, Inc. entered into an agreement to plan, install, and evaluate a micro-computer based monitoring and control system at Deserado Mine, an underground coal mine. The U.S. Bureau of Hines contracted the Colorado School of Mines (CSN) to independently evaluate the project. CSM evaluated and documented costs, benefits, problems, and management and labor perceptions in this report. Recommendations are provided for mine operators and monitoring system vendors considering future installations.

Jan 1, 1986

By John C. Machisak

Employment and related injury experience of the coking industry in the United States for 1957 contained in this publication is summarized under three general sections: (A) General injury experience: Tables 1 to 9: Current and comparable statistics on operating data, number, frequency, and degree of severity of injuries and major accident agencies involved in the cause of Injuries. Data are presented for the industry as a whole, for each type of oven, and for the States in which coke was produced.

Jan 1, 1959

By E. G. Deane

THE CHAIRMAN (P. G. BECKETT, Globe, Ariz.).-The mining of large orebodies has in the last few years been such a big factor in the copper output of this State, and, in fact, of the whole country, I feel that we should have some valuable discussion this evening on the various mining methods described in the papers which are to be read; and I hope you will start a discussion on Mr. Deane's paper. J. A. EDE, La Salle, Ill.-I would like to ask whether, the timbers being left in, they have any fires owing to that fact? E. G. DEANE.-No, we do not. The timbers in the mat seem to lose life. I cannot tell you exactly what change takes place, but they do not burn readily. There is undoubtedly a chemical change in them-a change that makes them lose all strength. I , spoke of the strength of the sills. When we first started, we put in 4 by 8 sills, but those sills had no more strength in 6 months than a 2-in. plank would have. .J. P. HODGSON, Bisbee, Ariz.- I would like to ask Mr. Deane if the central supply raise in the- center of the block has been satisfactory; and also whether in extracting the ore they put small raises up so that wheelbarrows are not used in the stope?

Jan 12, 1916

By Y. Fu, C. Aldrich

This study investigates the use of dense convolutional neural networks to estimate bubble size distributions in flotation froths. 20 videographically captured images of froths from an industrial platinum flotation plant in South Africa were labelled semantically with an image annotation tool, LabelMe (https://github.com/wkentaro/labelme). As a result, pixels in the images could be categorized into three classes, namely ‘bubbles’ (class 0), ‘bubble boundaries’ (class 1) and ‘background’ (class 2). A U-net architecture with a ResNet34 backbone was trained to segment the images via classification of the pixels in the images. 5 of the 20 images were used to validate the performance of the neural network. Explicit inclusion of the bubble boundaries as a class proved to be significantly more effective than training the network with two classes only (i.e. bubbles and background). However, the thickness of the boundary layer regions were critical. If too thin, it was difficult to distinguish between some contiguous bubbles and if too thick, some fine bubbles may not be identified. The results were promising, although there is still significant scope for improvement, among other by making use of more images for training and validation. Keywords: Flotation Froths, Convolutional Neural Networks, Deep Learning, Bubble size Analysis

Jan 1, 2020

By JO. E. SHERID

THE Dawson coal-mines are owned and operated by the Stag Canon Fuel Co., of which Dr. James Douglas is President and E. L. Carpenter general manager. The property is situated in Colfax county, N. M., and the openings now in operation are in townships 28 and 29 N. R. 20 E., and township 28 N. R. 21 E., shown in Fig. 1. The mines are part of the southern end of the Raton coal-field, which extends north into Colorado and embraces many coal-camps of the Trinidad section. II. GEOLOGY. Geologically, the coal-measures, commonly known as the Laranmie series of the Cretaceous system, have a thickness of about 800 ft. in the vicinity of Dawson. The coal makes an excellent coke, and, according to some authorities, its coking properties are clue to the action of intruded sheets and sills of igneous rock, the sheets occasionally thickening into masses resembling laccoliths, at such places making nearer approach to the coal and sometimes producing small areas of natural coke. There are but few dikes through¬out the entire southern portion of the field and little or no faulting along the dikes. In some parts of this great coal-field the intrusive sheets are far removed in the green shales below the coal-measures, and are so much altered as to be difficult of identification. There is but little disturbance of the strata through¬out the Raton coal-field in as far as it extends into New Mexico. There are two workable seams in the coal-measures, and two or three smaller coal-seams, ranging from 1 to 2.5 ft. in thick-

Jun 1, 1909

By John F. Elliott, Robert D. Pehlke

The rate of reaction of nitrogen with liquid iron and with binary alloys of iron and Al, Cb, Cr, Ni, O, S, Si, and W were measured. The surface active elements, oxygen and sulfur, decrease the rate markedly. The other alloying elements have very little effect on the rate except when they function as deoxidizers, The rates of absorption and de-sorption were found to be equal. Several possible reaction mechanisms which may control the rate are considered. In order to describe completely the behavior of nitrogen in steelmaking processes, the mechanisms of mass transfer between the gaseous and liquid phases, nitrogen and iron, respectively, must be understood. A kinetic study to determine the nature of these mass transfer processes was undertaken, and the results of that investigation are presented in this paper. Specifically, the study was directed toward determining the influence of alloying elements on the rates at which pure nitrogen gas at constant pressure is absorbed and desorbed by liquid iron solutions: A previous paper1 reported measurements of the equilibrium solubility of nitrogen in liquid binary iron alloys. The experimental data are presented and discussed first and then several possible rate limiting mechanisms are considered. PREVIOUS RESEARCH The results of several investigations on the rate of absorption of nitrogen by liquid iron and iron alloys have been reported.2-14 There is little agreement on the rate coefficients among these studies because of the influence of geometry on the experimental system and of the purity of the liquid iron. The rate was found to be influenced by alloying content for the binary liquid iron systems: Fe-Al,2 Fe-C,4,6 Fe-Cr,4,5,8 Fe-Mn,5 Fe-Ni,5,8 Fe-O,9,10 Fe-O,9,10 and Fe-Si.2,6,7,11 Several investigators12"15 have reported that the rate of nitrogen absorption is increased in a reducing gas mixture and decreased in an oxidizing atmosphere. A mechanism for the retardation by oxygen of the absorption of nitrogen has been described by Naeser18 as the formation of an iron oxide film at the gas-metal interface. The film slows the absorption rate until it disolves in the metal, thus permitting nitrogen to enter the liquid iron. Karwat17 discussed the influence of oxygen in terms of the formation of gaseous molecules of nitrous oxide which represent a higher energy form than the nitrogen and oxygen or the oxidizing gas and consequently constitute an energy barrier for the process. Fischer and Hoffmann10 showed that the oxygen markedly reduces the rate of absorption of nitrogen, the rate constant being one order of magnitude smaller in liquid iron containing 0.15 to 0.24 pct 0 as compared to that in melts containing 0.001 to 0.02 pct 0. Although Chipman and Murphy2 reported that the rate of absorption of nitrogen in liquid iron was essentially independent of temperature, Eklund3 found that the rate increases strongly with increasing temperature as did Kootz4 and Saito.5,6 Karnaukhov and Morozov7 also reported a large temperature coefficient, but related it to increased stirring at higher power inputs in an inductively heated system. All of the authors above have treated their results assuming that the reaction is diffusion controlled, that the surface reaction is in equilibrium with nitrogen gas, and that a "first order" reaction takes place. Karnaukhov and Morozov7 and Humbert; who studied the rate of absorption in a closed system by observing pressure changes in the system as a function of time, concluded that their results best fit a diffusion-type analysis. This was further verified by von Bogdandy, Dick, and stranski18 and Fischer and Hoffmann10 who found the initial rate of

Jan 1, 1963

By Q. Liu, P. Katsabanis, J. A. Meech

A thermohydrodynamic computer code has been used to simulate dust explosions. For sulphide dusts, the thermodynamic predictions are used to investigate the effect of dust concentration, mineral content and inert materials as well as the quantity of sulphur dioxide produced. It was found that the amount of oxygen available for the explosion is very important and that the dust concentration which gives maximum explosion pressures is obtained at zero or slightly negative oxygen balance values. The sulphide minerals were found to have the following explosibility sequence: pyrrhotite, pyrite, chalcopyrite, sphalerite, covellite, chalcocite and galena, which is in agreement with mine experience. The results show that theoretical calculations can be used to predict explosion pressures and toxic gases produced by a dust explosion and therefore they can assist in the design of protective measures .

May 11, 1988

By G. T. Daware, M. J. Chaddha, S. P. Masurkar, P. G. Bhukte, A. Agnihotri

JNARDDC has evaluated bauxite deposits of India from the geo-technological point of view. During the evaluation studies, it was observed that bauxite deposits are associated with saprolite resources. During bauxite mining, various low-grade materials such as saprolite, laterite and low-grade bauxite are generated. These materials typically have low-alumina, high-iron oxide and high-silica content. Owing to their inferior quality, these materials cannot be used for alumina production and hence remain unutilized at the mine site. For the present study, the saprolite samples were collected from the Western Ghats bauxite deposits in India. The sintering studies were conducted on saprolite granules using a variety of parameters. The sintered granules were characterized, and their properties determined. The test results showed that bulk density, apparent density, porosity and refractoriness (PCE 1645–1659 °C) of the aggregates were within the range of refractory specifications. The feasibility tests carried out at the refractory industry indicated that the developed aggregates are suitable as refractory material and can substitute for calcined clay. Currently, high-purity clay resources used in the refractory industry are limited and fast exhausting; therefore, the industry is likely to face an acute shortage of raw materials, which will become more critical in the future. Therefore the sintered granules (aggregates) developed from saprolite, which is a mining waste, provide a low-cost, eco-friendly solution for the fast-exhausting resources of the high-purity clays. The developed process may change the Indian bauxite mining scenario because saprolite may substitute as a potential raw material for the refractory industry.

Apr 12, 2021

?ADAIR, ARTHUR C., Corp 4th Co., 1st. Training Bat., 154th Depot Brigade. ADAMS, HENRY, Major: Chemical Warfare Service. ARLUCK, A. A Headquarters, 1st Corps of Artillery. ASKIN, THOMAS B. H Ensign. BANKS, H. R., 2d Lieut Canadian Engineers. BAYLESS, G. E. S Supply Dept. U. S. Submarine Base. BELL, L. R Co. C, 302d Engineers. BELLIS, ARTHUR E., Capt Ordnance Reserve Corps. I BIRRETT, HOWARD, Lieut., Aviation Section, U. S. Signal Corps, Ellington Field. BOISE, PAUL T 2d Regiment, 24th Squadron. ?BRADLEY, CLARENCE I Convois Automobile Section 585. BROWN, GEORGE M Co. G lot Engineer Replacement Regiment. BUCKINGHAM, ALBERT U. S. S. " Coronet," S. P. 194, Section Base No. 7. BURNS J. J Co. 1-B, E. R. O. T. C. BURT, Co. B, let Engineers Replacement Regiment. ||BYERS, WHEATON B., 2d Lieut Ordnance Dept. CANTON, WILLIAM R., Sgt Headquarters Co., 80th F. A. CARSON, JOSEPH A., Capt A.S. S. R. C.' CHAPMAN, LEWIS C. Corp 29th engineers. CHETNEY, P. C., 2d Lieut 15th Bat. Headquarters Co. CHEVRILLON Louis French Red Cross. CHIDESTER, W. B., 1st Lieut 24th Machine Gun Bat. CHURCH, JOHN L., Capt 308th Engineers. CLAGHORN, D. MONTGOMERY, 1st Lieut 45th Engineers. CLAQHORN, JAMES L., Lieut Aviation Section, Signal Corps. CLARKE, ALEXANDER F U. S. Naval Aviation Service. COMINS, WALDO H. Ca t 41st Co., 164th Depot Brigade. COOK, FREDERICK A., Capt., Engineer Reserve Corps, Asst. to Div. Engr. 79th Division. COOPER, CLAUDE H. Capt C. A. R. C., 50th Artillery. COPELAND, N. R., Lieut. ||CORBY H.. G., 1st Lieut Co. D, 109th Supply Train. CORSA, BEAN, Capt Co. D, 612th Engineers. CORTESE, EMILIO Italian Army. COULDREY PAUL S., Corp British Expeditionary Forces. || CRAGIN, RODNEY S Co. E, 115th Engineers. CURRIE, JOHN M., Ca t Royal Engineers. || CUTTING, G. W., 2d Lieut U. S. Reserves, Field Artillery. V DARRINGTON, PAUL N., 1st Lieut U. S. Infantry. DAVIS, ANGUS W., Lieut-Col British Expeditionary Forces. || DAVIS, THORNTON, 1st Lieut 13th Field Artillery. ELAND, FREDERICK A., Major Engineer Reserve Corps. DOUGLAS, JAMES $ American Red Cross. DOVE, D. R., Candidate 21st Training Battery, F. A. C. O. T. C. Dover JAMES J 6th Co. C. B. DOWS, DAVID,Capt Coast Artillery, Officers Reserve Corps. || DRAKE, M. 6., 2d Lieut Headquarters Co., 325th Infantry. I || EMMERSON, E. Roy British Navy. EVERIT, RICHARD STURTEVANT Heavy Artillery Officers' Training Camp.

Jan 1, 1923

"In response to needs created by intensive exploration and accelerating expansion of coal mining in the Western provinces, Canadian R & D on coal is progressively widening its scope. Principal interests continue to lie in coal geology, preparation and processing, carbonization, combustion and transportation, but much active work is also in progress with respect to mine environments, mined-land reclamation, and environmental consequences of coal mining, processing and use. Long-range 'basic' research, which characterized much of the R & D pattern in the fifties and early sixties and which was often no more than an attempt to prevent total extinction of a dying industry, has been somewhat de-emphasized, except insofar as it relates to 'safe' coal storage and to coal-based carbons (which are beginning to command attention as pollution control media).In this review, recent exploration, mine development and new preparation facilities are noted, and current R & D in transportation, processing, handling, carbonization and combustion is summarized. Reference is also made to investigations bearing on non-fuel uses of coal (notably as source-materials for carbons and agrobiological products)."

Jan 1, 1970