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By J Vann

Geometallurgy is inherently multidisciplinary and it gains its power to deliver improved outcomes for the minerals industry by bridging silos between disciplines. This cross-disciplinary approach unlocks value, identifies (and avoids) value destruction and provides a pathway to better implementation of an energy efficient and sustainable minerals industry. Despite this promise, we argue that the cross disciplinary approach also represents the greatest threat to the success of geometallurgy. Some key cross disciplinary issues identified are:Geometallurgy has so far evolved in the technical sphere, mainly by collaborations of geologists and metallurgists. Consequently, in many cases the business dimensions and value have not been incorporated. Financial and risk evaluation viewpoints need to be assimilated into the geometallurgical paradigm. In fact, until such measures are integrated into practices, the value cannot be fully demonstrated.The historical and current efforts on geometallurgy have been highly focused on improved sampling and measurement of geometallurgical properties or appropriate proxies. This work has been driven by professional and academic geologists and metallurgical engineers. It is notable that mining engineers (who are critical in the value delivery of geometallurgy through changed planning approaches) have so far been at the margins, or absent. The construction of valid three dimensional (3D) geometallurgical models raises some important organisational, mathematical and geostatistical considerations. The enhancement of resource models to account for geometallurgical aspects must be managed carefully if the full value of geometallurgical thinking is to be realised.The use of 3D geometallurgical models to change business decision making and practices is the real nub of the problem. We believe sophisticated scenario based evaluation methods are required if the potential impacts of spatial rock properties on processes further down the mining value chain are to be realistically evaluated. Such changed practices require ‘whole of value chain thinking’ to embed this change into the business in an ongoing way.Because profitable geometallurgy demands changed approaches to business decision-making and also organisation of the firm (radically changed in some cases), the senior executive viewpoint must be incorporated into the language and thinking of geometallurgy. This is unavoidable if the establishment of a geometallurgical approach to project evaluation, development and operation is to be successful and sustained.A powerful analogy for the problem faced by geometallurgy is the transformation of safety culture in the mining industry in the past 20 years. We argue that, as in the safety revolution, explicit models, cultural change and management of the ‘soft’ dimensions of the problem are pivotal to success of geometallurgy. In light of this, we propose a model (‘the Geomet Curve’) that gives a framework and pathway for geometallurgy in seven steps. The implications of this model for technical and organisational steps required at different stages are discussed.

Sep 5, 2011

By Taylor G. R

Fluid inclusions within quartz accompanying several stages of mineralization at Hillgrove are de cri bed. Pyrite-arsenopyrite-gold mineralization shows uncorrected filling temperatures of between 195°C and 250°C. Later stibnite-antimonide-siderite and stibnite-calcite mineralization has filling temperatures between 100°C and 195°C and a bimodal distribution of temperature peaking at 175°C and 145°C, possibly correlated with the two stages of mineral deposition. Secondary included fluids within an earlier generation of deformed quartz veins are derived from hydrothermal fluids contemporary with the main-stage mineralizing fluids described above. Primary inclusions within latestage, cross-cutting quartz-chlorite-calcite veins show these veins to be unrelated to the mineralization.A correlation between filling temperatures and salinities indicates that mineralization accompanied the mixing of a hot, partly saline, fluid (at 5 per cent equivalent NaCI) with cooler, less-saline meteoric or connate water. Over a vertical distance of 200 m, equivalent mineral assemblages were deposited over the same temperature range. Studies on single crystals suggest rapid deposition with fluid temperature dropping 45°C during their growth. Ore mineragraphy and the fluid inclusion data suggest that the metals were transported by sulphur-poor, relatively low-temperature, low-salinity solutions, possibly as carbonate complexe , and that a vertical zonation of the W-Sb-Au mineralization is compatible with the mixing of this hydrothermal fluid with cooler groundwater. Regional metallogenic and geological considerations suggest that ore metals are derived from the remobilization of deep-seated stratabound deposits or from metamorphic fluids expelled from deepseated volcanoclastic sediments.

Jan 1, 1984

By R O. Laidlaw, J L. Mauk

The Coeur d'Alene mining district in northern Idaho, USA is the second largest producer of silver in the world. Mesothermal silver-lead-zinc veins occur in the metasedimentary rocks of the Belt Supergroup with five main types of associated hydrothermal alteration: 1) feldspar destruction, 2) hydrothermal bleaching, 3) carbonatisation, 4) sulfidation, and 5) silicification. Hydrothermal bleaching is characterised by hematite destruction with associated siderite and quartz veins and veinlets, coarse euhedral pyrite and magnetite. Bleached zones envelop both mineralised and barren veins and extend for metres to tens of metres into the wall rocks. Carbonatisation consists of addition of siderite, which occurs as veins, veinlets, stockwork, irregular blebs or spots, and coarsely disseminated grains, depending on the relative distance from the main vein structure. Siderite envelops nearly all mineralised veins, relates to all other alteration types and extends from several metres to tens of metres into the wall rocks. Pyrite and galena alteration dominate sulfidation and are associated with some mineralised veins. Pyrite alteration strongly correlates with siderite alteration and exists in three main forms: a) very fine-grained pyrite flooding, which can extend for metres to tens of metres into wall rocks; b) coarse-grained, euhedral pyrite, which is sporadic and associated with the redox boundary in hydrothermally bleached zones; and c) small isolated zones (6 - 15 cm) of medium-grained, subhedral to euhedral pyrite associated with pervasive siderite alteration. Where present, disseminated galena extends for metres to tens of metres into the wall rocks. Silicification is characterised by veins, veinlets, stringers, irregular patches and variable hardness in siltites and commonly appears in association with hydrothermal bleaching and siderite alteration. Although related to mineralisation, silicification is sporadic and in most places a clear envelope around mineralised veins cannot be identified.

Jan 1, 2001

By T M. Campos, H A. Petit, L M. Tavares, R Olympio

Much practical experience has been gathered in the last 30 years of application of high-pressure grinding rolls (HPGR) integrated with ball milling in size reduction of fine iron ore concentrates. The company Vale S.A, in Complexo de Tubarão (Brazil), was one of the pioneers applying the technology prior to pelletisation with an outstanding size reduction energy efficiency in the circuit and a significant increment in the specific surface area of the product. Recent studies by the authors demonstrated benefits of modelling and simulation to improve the performance of HPGRs in this particular application, with the model being able to describe HPGR performance under different operating conditions and under variations of feed size distribution. Despite these important advances, this modelling approach has only been used offline and under steady-state conditions. The present work applies the modified Torres and Casali model proposed by the authors in pseudodynamic simulations. The ability of the model to predict the characteristics of the product in real-time is evaluated using data available online for the pellet feed preparation circuit. Results demonstrated the model capabilities to map the physical operation and give a realistic representation of the process. Additionally, the model is demonstrated to be able to support the pellet feed production by providing extended real-time information of the process, making it a useful tool for improvement of the operational strategies and process stability.

Aug 24, 2022

By Beer G

The recent re-emergence of an Integral Pressure Stripping system which operates with both cell and column in closed circuit at elevated temperature and pressure, requires no cyanide in the eluate solution and has greatly reduced carbon reactivation requirements in seen as a progressive step in this area. Several of these re-configured IPS systems have been placed in service in Australia and overseas in the last three years, with the first of the new generation units constructed and commissioned by Como Engineers Pty. Ltd. at Mt. Fisher in the East Murchison of W.A. in September 1987. This plant was relocated to a new ore body at Darlot W.A. in February 1989. Use is made of a data base of raw plant performance figures from both Mr. Fisher and Darlot and its performance compared with other operating plants. Initial commissioning difficulties of the Mt. Fisher prototype and dis- cussed together with the modifications and operational procedures required to overcome these problems. Stripping times of less than 6 hours at 145 degrees have been achieved with barren carbon values less than l O ppm from loaded carbon values above 3000 ppm and with cell pass efficiencies reaching 90 per cent.

Jan 1, 1991

By S Ferguson, G Noble

The mining industry is facing economic pressures to treat more challenging and lower grade ore types, as well as pressure relating to environmental impact and social license to operate. Preconcentration through bulk ore sorting has the potential to benefit all these areas by enabling mining operations to divert material of low economic value prior to processing, thereby achieving higher feed grades and recovery, while reducing the processing plant and tailings dam footprint and capital required throughout the life of mine. The effectiveness of bulk ore sorting depends on the heterogeneity of material at the measurement location, as well as the accuracy and precision of the measurement. An understanding of ore heterogeneity can be assessed using drill core data, which provides metre by metre elemental assays. This paper reviews such data and assesses the grade distributions over different scales, which suggests that sufficient heterogeneity exists at mining scales to allow the potential for bulk ore sorting. Prompt Gamma Neutron Activation Analysis (PGNAA) technology has proven to be a successful measurement technique within many industries, including mining. PGNAA was first developed in the early 1980’s for the measurement of the elemental composition of bulk materials on a conveyor belt. Today, Pulsed Fast Thermal Neutron Activation (PFTNA) technology is also applied in elemental analysis of bulk materials and has some advantages for bulk ore sorting. In order to enable effective bulk ore sorting, however, a PGNAA/PFTNA analyser must be designed to provide a representative bulk ore analysis with the necessary accuracy and precision. Examples are presented to provide an understanding of the factors affecting PGNAA/PFTNA performance in relation to effective bulk ore sorting.

Nov 10, 2020

By A Bird

Gravity gold circuits have an important part in reducing operating costs and maximising recovery in modern gold plants where coarse gold is present in the ore body. The design and selection of equipment has a vital part in the overall effectiveness of the gravity gold circuit. There are a number of associated factors that need to be taken into consideration when selecting the most suitable equipment for gravity gold circuits including occupational health and safety, security and labour requirements. This paper is a case study that outlines the validation behind the design, selection of equipment and subsequent benefits of the recent upgrade of the gravity circuit at the Marvel Loch gold mine with the main component to the upgrade being the installation of a Consep Acacia Reactor. Since the upgrade there has been a significant increase in gravity recovery, which has reduced the amount of gold reporting to the leaching circuit therefore reducing reagent consumption and overall operating costs. There has been an increase in overall gold recovery and therefore increased gold production. The benefits to occupational health and safety include the removal of toxic gases being released in the gold room during the previous practice of gold concentrate calcination and the removal of the arsenic and nickel from the gold doré, which poses a risk during refining. Manual handling and security has improved as there is no physical contact with gold concentrates during the automated process using the Acacia reactor. The total time for gold room personnel working in the gold room has also reduced from around six hours per day to less than one hour per day.With the continuing development of low grade gold deposits, there will be an increase in demand for low capital, high recovery gravity gold circuits that can significantly increase overall production while reducing operating costs.

Aug 8, 2011

Process engineering principles are used to analyse the features of leaching processes for large masses of low grade, unprocessed ore. Different performance characteristics are related to the numerous variants of these processes. The variant for which reagent enters a heap only via the input solution is further subdivided into three modes of operation. The three modes may occur in testwork and full-scale operations; the effects of process variables on the rate of the process are completely different in each mode. The mode can be identified by the time at which reagent first appears in the pregnant solution. It is related to the ratio of the height of the heap and the thickness of a band of ore in which the reactions are localised. Synthesis of the phenomena occurring within a heap via a computer program has produced a quantitative relation for the reaction band thickness. The program has been validated for several different systems. The overall achievement is that the mode of operation and the rate of the process can be forecast before column testwork is commenced. Some applications of the outcomes to testwork, process design and operational tactics are described.

Jan 1, 1994

By M I. Pownceby, N A. S Webster, J R. Manuel, J M. F Clout, E Donskoi, N A. Ware

The relative influences of sinter mineralogy, sintering temperature, solid and pore macro- and microstructure on iron ore sinter physical strength are not yet fully understood. Whilst a range of analysis techniques have been used by researchers to evaluate sinter physical properties and sinter mineralogy, none have been able to directly link sinter mineralogy and physical strength under controlled conditions. CSIRO has developed a unique laboratory method to study the fundamental melting properties of fine iron ores in a laboratory furnace under a controlled temperature and gas atmosphere environment designed to simulate the industrial sintering process. Compacted tablet samples for a 0.41 per cent and a 2.5 per cent Al2O3 series were fired in a tube furnace at various temperatures, cooled, then tumbled using a modified Bond abrasion test apparatus to determine a relative tumble index (TI) at each temperature. Quantitative XRD (QXRD) analysis was then carried out on the tumbled samples and optical image analysis (OIA) was conducted on polished sections of a separately fired compact in each case. The amount of total SFCA was found to decrease with increasing firing temperature for both alumina series with the total amount of SFCA higher in the 2.5 per cent Al2O3 series compared to 0.41 per cent Al2O3 series samples. The increase in the amount of magnetite and hematite with increasing firing temperature was largely at the expense of a decrease in total SFCA. Overall, there was good agreement between the quantitative mineralogy determined from QXRD versus OIA for SFCA, hematite and magnetite. Qualitative analysis of high magnification images of the sinter correlated with both the OIA and QXRD results.

Sep 18, 2023

By A Purvee, M F. Lee, L J. Mollison

Oyu Tolgoi is a large Cu-Au porphyry deposit in the south Gobi desert, Mongolia. The first of several deep, large-diameter, concrete-lined shafts, Shaft 1, is nearing completion. It will have a finished depth of 1380 m at a diameter of 6.7 m. These shafts will provide access to and hoisting capacity for block caving of deep underground ore. Geotechnical site investigations, and associated predictions of stability and ground support requirements, are compared against actual construction performance. Routine mapping is essential, along with checks against predictions and informing the contractor of ground conditions and variances.Advance rates are compared against predicted rock mass quality. A reasonable correlation exists between Qwall and advance rate. Overbreak and concrete liner thickness is related to the blockiness quotient, RQD/Jn.A ætool-bagÆ of just a few support elements (chain-link mesh, fibrecrete and 2.4 m long friction anchors and resin grouted re-bar bolts) was able to cope with the ground conditions encountered. QA/QC procedures are essential from the factory, through site storage to installation.

Jan 1, 2008

By D J. Brake

In most underground mines, the ventilation system is a significant portion of the total mine capital and operating cost and the largest consumer of underground electrical power. The effectiveness of the ventilation system has a major bearing on the safety, health, comfort and morale of underground personnel, and has a critical role in meeting production targets and therefore business revenue. Perhaps the most important component of the primary ventilation system is the primary fan. Correct performance testing of the primary fan during the warranty period is important not only to ensure the mine has obtained the asset that it paid for and can therefore deliver on the fanÆs crucial safety and economic role in the future of the mine, and to provide a justification for releasing final performance warranty payments to the supplier, but also to provide a benchmark or baseline against which to assess future performance issues. As there are at least three potential international standards available to measure fan performance, there has been considerable confusion regarding which of these to use for testing primary mine fans, and also the correct allowances and tolerances to use. This paper provides guidance on which standards to use for different applications, how the standards should be interpreted, what allowances and tolerances are reasonable, and other important issues to be resolved with the fan supplier prior to making a contract award. The paper also discusses practical issues and methodology for in situ primary fan performance testing.CITATION:Brake, D J, 2013. Performance and acceptance testing of main mine ventilation fans, in Proceedings The Australian Mine Ventilation Conference , pp 141-148 (The Australasian Institute of Mining and Metallurgy: Melbourne).

Jul 1, 2013

By King R. L

The Bureau of Mines has developed and deployed three expert systems to give advice on mining health and safety. These are: dust control for continuous miners, dust control for longwall shearers, and methane control. All three systems query about the nature and extent of the problem. Typical questions asked deal with observed methane levels, ventilation type and quantity, cutting sequence, and what control technology is employed. Advice given does not focus on a single issue, but may suggest a variety of approaches consistent with the ability of the operator to implement the Suggestions.

Jan 1, 1988

By M Szwec, P Corbett, P Sheffield

Centennial Coal operates the Springvale and Angus Place longwall mining operations that extract coal beneath the Newnes Plateau in the Western Coalfields of New South Wales. Springvale and Angus Place mines have a history of difficult geotechnical conditions, where mining operations are conducted with a thick coal roof interbedded with numerous claystone units and relatively high levels of vertical and horizontal stress. The combination of a relatively high stress regime and weak laminated roof has led to numerous roof failures throughout the mine’s life.Following underground roadway development, the mine roadways can experience high levels of roof movement that can lead to roof falls. Two-point wire extensometers (known as ‘telltales’) are extensively used for roadway condition monitoring. Along with extensive other geological and geotechnical data, monitoring data is used to prepare geotechnical hazard plans that are then used in all areas of mine planning to allow for safe and efficient operation of the mine.This paper presents a case study of the use of a new software tool that allows time-scaled visualisation of monitoring data in the context of longwall and development face positions and installed strata support. It can be used in the identification of geotechnical risk factors and their interaction with the mining process to allow a more robust geotechnical hazard process. It interfaces directly with the widely used ExtoChart database software and can be presented with scale drawings of geological/geotechnical data to allow correlation of monitoring data with risk factors.CITATION:Corbett, P, Sheffield, P and Szwec, M, 2014. A new tool for extensometer data analysis and improved understanding of geotechnical risk factors, in Proceedings AusRock 2014: Third Australasian Ground Control in Mining Conference , pp 217–232 (The Australasian Institute of Mining and Metallurgy: Melbourne).

Nov 5, 2014

By D Horacek, I K. Sheppard

Ok Tedi is in a period of transition. By 2008 mill feed will consist of higher levels of high-grade but metallurgically challenging skarn ores. Additionally, the Taranaki pit will start production in 2008 along with the start-up of a new pyrite concentrator. Taranaki ores are very high in sulfur. Sulfur is captured in a pyrite concentrate prior to tailing entering the Ok Tedi River. These and other complex scheduling issues will need to be resolved over a critical three-year period. With these requirements in mind, Ok Tedi contracted AMC Consultants to develop a custom version of the Life of Business Optimisation System (LOBOS¬) to assist medium-term production scheduling at Ok Tedi. LOBOS utilities enable Ok Tedi planning engineers to:import polygon-based reserve data (Blast Masters) from MineSightÆs Interactive Planning Tools (IP Tools); graphically construct block sequencing and material flow constraints; edit constraints defining standard scheduling, processing and financial relationships; define dump and stockpile attributes; and assign capacities to production systems, plants, dumps and stockpiles. LOBOS converts Ok TediÆs production scenario into a mixed integer program (MIP) and submits the resulting model to IlogÆs Cplex MIP Solver. The Solver seeks an optimal production schedule that maximises net revenue per mill hour while meeting all constraints. This paper introduces Ok Tedi and its production requirements and relates these requirements to the facilities developed for an Ok Tedi version of LOBOS.

Jan 1, 2007

THE area of the State of New South Wales is not great, nevertheless it has very large and important Mineral Resources. This is the more noticeable when the values of the annual mineral production from the individual States of the Commonwealth arecompared with the value of the New South Wales production. The principal minerals mined now are not gold, copper, and tin, as they were in the early years following the gold rush of 1851, the centre of gravity of commercial mineral activity having moved to coal and "oil-shale," water, limestone (with cement), silver-lead-zinc cadmium, sulphur, slate and other building and ornamental stone, road materials, and clays.From small areas totalling only 650 sq. miles, coal to the extent of 311,000,000 tons, valued at £151,000,000, has been won.The estimate of actual and probable reserves by the Mines Department within an area of less than 1000 sq. miles is about 14,000,000,000 tons, while the potential reserves within the remaining 15,500 sq. miles of concealed coal fields must be enormous. Even taking into account only the actual and pI:obable reserves in the 1000 sq. miles known, and assuming a depletion at the rate of 350,000,000 tons a year, or somewhat greater than that of the British Isles at present, and assuming an average value of £1 a ton, with money at 5% compound interest, then the present value of this coal (40 years of depletion) would be £5,575,000,000 approximately: truly an enormous present value for a business of 40 years, dealing only with 1000 sq. miles of country. The location of the main coal basin in New South Wales is one of great strategic importance. It lies almig and near a seaboard, with excellent facilities for anchorage; the coal is of very high quality, and is readily accessible; the climate is admirable. Were this same coal at Port Darwin, its commercial importance would not be be pronounced.

Jan 1, 1926

By M Yahyaei, F Reyes, R Lage, V Jokovic

Equipment wear is strongly related to the performance of grinding circuits. In particular, SAG mills are subjected to the wear of their shell liners and grates. Changes in lifter height and face angle impact mill performance, while classification at the mill discharge is also affected as grates wear out. Moreover, liner mass loss caused by wear affects how operators interpret readings of sensors such as load cells or bearings pressure. Automating and optimising grinding circuits under these constrain becomes challenging due to the nonlinear and dynamic nature of the system. The operation of SAG mill grinding circuits remains largely dependent on human intervention, which frequently results in inconsistencies in performance across shifts, reflecting the operator’s personal preferences, experience, and other human factors. The influence of human factors can be reduced by careful training of operators as well as by automation using advanced supervisory control. The latter approaches could benefit from the development of dynamic process models that consider the effects of wear on the performance of equipment over time. This paper presents detailed industrial data showing the effects of wear on SAG mill performance. Additionally, a dynamic SAG mill model that accounts for these phenomena is proposed and demonstrated in a simulated environment. This model is shown to mimic the effect of wear on the performance of industrial scale mills and the operational constraints they are subject to, thus extending traditional SAG mill models. Incorporating wear into modelling and simulation platforms can improve the understanding of the effects that wear can have on the performance of key assets in comminution circuits and may allow the development of more robust model-based advanced process control strategies.

Aug 24, 2022

The introduction of many new hydraulic ally and pneumatically powered impact breakers over the past few years demonstrates the growing interest in this technique of breaking rocklike material. The most practical method yet devised to increase the blow energy range of hammer type impactors without incurring weight penalities, is to cushion the impact of the hammer on the tool. This has been achieved in one impact breaker by means of replenisible fluid cushions between the tool and the hammer, and blow energies up to 27,000 joule (20,000 ft. lbs.) have been achieved. Impact rock breaking is becoming an important alternative to the use of explosives in the mining and the construction industry. The design of impactors is discussed and manufacturers data is presented for most of the machines now available. A review of the research and mechanics of breaking rocks with impactors is presented and the benefits of high energy impactors are discussed. The relative merits of three impactor design types are explored with regard to achieving high blow energy.

Jan 1, 1978

By D MacKenzie

The Rise & Shine Shear Zone is a shallow-dipping Cretaceous late metamorphic shear zone formed in a compressional environment. The Shotover mineralised system is dominated by normal faults with well-defined vein systems that cut across Miocene schist folds and faults related to the inception of the Alpine Fault. Despite the geological differences between these mineralisation systems, they share many common features of hydrothermal alteration that have resulted in disseminated gold in altered sheared schist. The most distinctive feature of both systems is the abundant ankeritic carbonate that has formed from decomposition of metamorphic chlorite. Excess iron from this alteration reaction combined with hydrothermal sulphur to form sulphides that host the disseminated gold. The chlorite decomposition reaction was reversed in the latter stages of both mineralisation systems, and this was accompanied by further gold emplacement in the Rise & Shine system.   Both alteration systems involved initial decomposition of metamorphic albite, followed by deposition of albite as a vein mineral in the latter stages. The fluid flow that yielded the disseminated gold was controlled by microshears that pervade host schists, in strong contrast to many Otago Schist vein systems where host rock alteration is absent. The ankeritic alteration in the Shotover and Rise & Shine mineralised systems has increased the volume of mineralised rock, and may have made suitable targets for large-tonnage, low grade gold deposits.

Jan 1, 2007

Completing its historical role the opera tion of copper blast furnace of the Saganoseki Smelter was terminated in 1970, but it left some interesting data on metal lumps formed at the furnace bottom. Analysis disclosed the lumps to be speiss containing 100 to 10,000 g/t of Au and Ag and stratified to iron speiss and copper speiss. Solidifying temperatures of iron speiss and copper speiss being approximately 1,090¦C and 800¦C respectively, copper speiss precipitated at the lower side. The distribution coefficient of Au and Ag between matte and speiss (g/t Au(Ag) in matte / g/t Au(Ag) in speiss) is in the range of 1 x 10 2 to 2 x 10 ' and 1 x 10 1 to 5 respectively. The higher Cu % is in speiss, the-more An and Ag are distributed into speiss. Except for a few data, these results comfotm well to the range of distribution equilibria of Au and Ag in matte and speiss systems by Gerlach and Others.

Jan 1, 1980

By R J. Romañach

The theory of sampling (TOS) is now followed in the development of near infrared (NIR) spectroscopic methods for the pharmaceutical industry. TOS has been the guiding light for a two-step approach for spectroscopic composite sampling available for the development of real-time analytical methods for particulate-based industrial processes. The two-step spectroscopic sample composite has been used in the development of process analytical technology (PAT), an important regulatory initiative to improve the quality of pharmaceutical products. The two-step sample composite approach overcomes the low sample volume analysed by PAT methods; one of the key limitations to PAT implementation in the industrial production of particulate-based materials.PAT methods need to be validated demonstrating their accuracy, precision, specificity and robustness. TOS provides a deeper understanding of these validation studies which involve discrete particulate material. The validation of PAT methods is now being performed considering both sampling and analytical errors, while practically all previous method validations only addressed the total analytical error (TAE) of these methods. This has been a crucial impediment for the field of chemometrics as well.PAT is a key element of continuous manufacturing (CM) processes, which are considered an emerging technology capable of increasing the flexibility, agility and robustness of pharmaceutical processes while reducing their costs. The outflow of the continuous process is a 1D lot, and variographic analysis has been shown to discern process variation from sampling and analytical errors in pharmaceutical CM processes. Thus, variographic analysis is a process improvement tool with significant potential for improving CM processes. The possibilities for improving pharmaceutical manufacturing are enormous.CITATION:Romañach, R J, 2017. Theory of Sampling – from missing link to key enabler for process analytical technology, in Proceedings Eighth World Conference on Sampling and Blending , pp 63–68 (The Australasian Institute of Mining and Metallurgy: Melbourne).

May 9, 2017