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By V. Castranova, K. VanDyke

"INTRODUCTION A soluble mediator has been described which is released from activated rabbit leukocytes and induces histamine secretion from rabbit platelets (Barbaro and Zvaifler, 1966; Siraganian and Osler, 1971). This factor has been isolated, characterized and named platelet activating factor, PAF (Bcnveniste et. al., 1972). PAF has since been chemically identified as l-0-alkyl-2-acetyl-sn-glyceryl-3-phosphocholine (Benveniste et. al., 1979; Demopoulous et. al., 1979).PAF is a lipid mediator of broad biological activity. It causes smooth muscle contraction, contraction of lung tissue and decreased FEV 1; while enhancing capillary permeability thus causing edema (Pinkard, 1983). In addition, PAF is a chemoattractant and can lead to inflammation.PAF has been reported to stimulate the release of lysosomal enzymes, leukotriene B,, and lipid metabolites from neutrophils (Smith et. al., 1983; Shaw et. al., 1981; Lin et. al., 1982; O'Flaherty et. al., 1984). The objective of the present investigation was to further characterize PAP-induced stimulation of granulocytes and to develop a bioassay, i.e. chemiluminescence, for screening PAF receptor antagonists and inhibitors of PAP-induced activation of granulocytes. The possible use of the chemiluminescence assay to monitor PAF synthesis by human granulocytes is also described.METHODSBlood was drawn from healthy volunteers into a blood storage bag containing CPD anticoagulant. Granulocytes were partially purified by dextran sedimentation and further purified by centrifugal elutriation as described previously (Jones et. al., 1980). Granulocytes obtained by this procedure were approximately 95 percent pure. The number of granulocytes in this preparation was determined using an electronic cell counter (Coulter Model Z1, Coulter Instrument Co., Hialeah, FL). Isolated granulocytes were used to monitor membrane potential, hydrogen peroxide and superoxide release, oxygen consumption, calcium uptake and, in some cases, chemiluminescence. Studies of PAF receptor antagonists were conducted using neutrophils isolated by density centrifugation. Briefly, blood was layered onto Mono-Poly-Resolving Medium (Flow Laboratories, McLean, VA) and centrifuged at 22 °C and 300 g for 30 min. Neutrophils collected from the second band of this gradient were at least 90 percent pure."

Jan 1, 1989

Develop a cost-effective, flexible method for extinguishing underground coal mine Fires that can be readily used in fire conditions encountered in both abandoned mines and coal outcrops. In addition to the abatement of an underground coal fire, a secondary objective was to prevent subsidence by filling the voids with a material having sufficient compressive strength to minimize subsidence. Approach The Colorado School of Mines Research Institute was awarded a research contract to determine the viability of using Foaming Mud Cement for abating underground coal mine fires and preventing subsidence. The program consisted of a laboratory and pilot scale investigation and process development. An extensive, controlled test program was conducted simulating floor, rib, roof and rubble fire conditions. Field demonstrations were conducted after the pilot scale research was completed. How It Works Traditional techniques have targeted the control of burning by eliminating the air, fuel source or heat. This has been accomplished by trenching, quenching, mothering or combinations of these three methods. These techniques were not always successful, particularly in the case of fires in abandoned mines.

Jan 1, 1991

By L. C. IlsLey, R. A. Kearns

As the use of electricity becomes more and more general in mining opera- tions, interest in regulations governing its application becomes greater. During the past year the electrical section of the Bureau of Mines has made a study of State regulations now in force relating to the use of electricity in coal mines. Technical Paper 271, entitled "State Mining Laws on the Use of Electricity in and about Coal Mines", has been published as a result of this study. The present paper represents a compilation of all laws relating to accident prevention with respect to electrical circuits. This group of regulations is perhaps the most important of any that relate to safety in coal mines. Its importance is shown by reference to accident statistics in Bulletin 115, (Fay, A.H., Coal-Mine Fatalities in United States, 1870-1914, Bureau of Mines, 1916), which show that about 77 per cent of the fatalities due to electricity in and about coal mines were caused by direct or indirect contact with trolley or other power circuits. In actual number this means that of 710 men killed by electricity, 546 were killed by contact with electric wires. Undoubtedly, a large percentage of these accidents might have been prevented had the wires been properly guarded. The compilation follows:

Mar 1, 1921

By M. W. Von Bernewitz, E. H. Denny

The use of oxygen breathing apparatus during rescue and recovery operations at both coal and metal mines has become so commonplace that there is a tendency for the industry not to give such apparetus the full measure of credit that it deserves in any particular disaster , therefore , the data presented herein should give some idea of what has been done in this regard during the past 15 years that is , up to 1910 by the Technologic Branch of the U. S. Geological Survey , and thence ( to the end of 1922) by the U. S. Bureau of Mines .

Feb 1, 1923

By W. H. Forbes

The prevention of accidents from falls of roof and coal requires a considerable amount of personal judgment , for conditions are different even in adjoining working places in the same mine , and conditions may change from hour to hour even in the same working place as the coal is shot down and loaded . Experience has shown that many men can not or do not exercise enough care to protect themselves from injuries ; moreover , where the foremen have been made directly responsible for the safety of the men under them , accidents from falls of roof and coal have , in many instances , been reduced as much as 50 per cent . There is now no question that careful , constant , and intensive supervision is essential in preventing acci- { dents and more especially accidents of this class . Falls of roof and of coal account for approximately 50 per cent of all coal mine accidents and annually result in the death of approximately 1,000 men and cause lost - time injury to approximately 50,000 men . These and other accidents are recurring with little or no diminution , usually not because of the lack of knowledge of safe and dangerous practices , or of the technique of safety , but largely because of the lukewarm interest of major executives in safety or the failure of mine officials to formulate and to enforce common - sense rules and regulations . When failure is the outcome of a sincere attempt of the managing officials to teach safety to the miner , the fault may usually be attributed to misguided effort . Various solutions for the problem of eliminating accidents from falls of roof or coal have been suggested , some of which are : Standard system of timbering for the specified mining districts ; departure from the room-and - pillar system to a more concentrated system of mining ; more intensive supervision - that is , 1 section foreman for every 25 loaders instead of 1 section foreman for 75 , 80 , or even more loaders the practice in most mining districts . - However , investigations conducted by the writer at numerous mines operated by a number of mining companies in several districts show that employees and officials alike are inclined to work under loose and unsupported roof , relying solely on the " drummy " sound and on their judgment and experience as to whether the roof will stay in place for one hour or for several hours . With but few exceptions , men who had been injured by falls of roof or ccal or were found working under loose and unsupported roof , admitted that they knew of the possibly unsafe condition , but it was their opinion that the roof or coal was not loose enough to fall for some time .

May 1, 1931

Objective: To improve the effectiveness of dust collector capture on surface mine drills.

Oct 1, 2005

By A. B. Hooker, L. C. IlsLey

The greatest hazard of early mining was from explosions of methane ignited by open lights . With the advent of safety lamps and forced ventilation this hazard was greatly reduced until the application of electricity to modern mining not only multiplied the sources of gas ignition but the accompanying , machines and haulage systems increased the amount of explosive dust , through which a methane explosion is more liable to become a major mine disaster , and thus greatly furthered the need of adequate ventilation to keep down the concentrations of methane . Adequate ventilation is still the best preventive of such explosions . However , even with a well laid out and controlled ventilating system the amount of air passing through entries and rooms is liable to vary within wide limits because of open doors , falls of rock , or other accidental causes . The percentages of methane under normal conditions should therefore be kept so small that they will not be increased to explosive proportions by short interruptions in ventilation . Mine ventilation and methane detection are inseparable safety precautions . The increasing importance of ventilation necessitates more accurato determinations of the methane concentrations throughout the mines . This paper discusses in detail some of the steps in the development of methane detection and specially notes the more accurate detectors now available . One of the earliest means of detecting methane was by a candle . About 1835 , John Buddle , Sr. , a noted mining man of his period , when questioned by a Parliamentary Committee as to the safety of using candles , replied :

Jun 1, 1933

By Lucia Kuizon

Results of the U.S. Bureau of Mines' survey of mineral resources in the Cuyama RARE II study area indicate there is no potential for metallic minerals and low potential for the development of gypsum resources. There are no producing or developing mines within the study area. The Santa Barbara Canyon Prospect contains 30,000 tons (27,000 t) of subeconmic gyspum resources, the Wagon Road Prospect 276,000 tons (250,000 t), and the Brush Fence Canyon 61,000 tons (55,000 t). Most of the resource in the Brush Fence Canyon Prospect is outside the area. Gypsum was not observed at the Cuyama River deposit. Present gypsum and gypsite requirements are being met by larger deposits closer to major markets. INTRODUCTION Location (USGS) Present and Previous Studies (to be combined with USGS section) The Bureau of Mines reviewed literature and mining claim records for the study area. A field examination of known mineral properties was made in October 1980; it included mapping and sampling of prospects to evaluate the economic potential of mineral resources.

Jan 1, 1981

To develop a quick, safe, and effective method that allows workers at mineral processing operations to clean their dust-soiled clothing periodically throughout the workday. Background Reducing workers' respirable dust exposure to silica and other harmful dusts and contaminants is an ongoing goal in the U.S. mining industry. One area of known worker exposure is from contaminated work clothes. A U.S. Bureau of Mines report documented a number of cases where a tenfold increase in a worker's dust exposure was measured from contaminated work clothes. In these cases, the dust emitted from clothing caused the worker's dust exposure to exceed the permissible exposure limit in less than 2 hours. The most effective way to eliminate this dust source is to have workers clean or change their work clothes. There are two federal regulations that impact the clothes-cleaning process. The first states that at no time shall compressed air be directed toward a person, but that when compressed air is used, then all necessary precautions shall be taken to protect persons from injury. The second regulation states that compressed air should only be used for cleaning purposes when it is less than 30 psi and used along with personal protective equipment. For the mining industry, by default, the only approved method to perform clothes cleaning is to have workers vacuum their clothes using a HEPA filter system. This is very difficult and time-consuming and, in most instances, not very effective. Most workers would prefer to use a single compressed air hose to blow dust from their work clothes. However, not only is this method prohibited by law, it usually creates a significant dust cloud in the work environment and contaminates coworkers.

May 1, 2005

By L. A. Johnson

This Bureau of Mines report presents the analysis of three cores from the Asphalt Wash area of the P.R. Spring tar sand deposit of northeastern Utah. Two tar sand zones are indicated in the Asphalt Wash Area. Total net thickness of the tar sand ranges from 23 to 39 ft, with occurrences between 56 and 263 ft in depth. The sand has average porosity of 24.7 pct of bulk volume, average permeability before and after extraction of 87.5 and 596 md, respectively, and average oil saturation of 58.1 pct of pore volume. Oil gravity averages 10.9° API.

Jan 1, 1975

By Charles Vaught, Belinda Sue Mills, Henry P. Cole, William J. Wiehagen

This study reports the results of a survey of organizations that used problem-solving simulation exercises to support mine health and safety training. The exercises are designed to teach judgment and decision-making skills within two broad domains: (1) how miners respond to mine emergencies (e.g., first aid, self-rescue, and escape) and (2) how miners integrate safety concepts within the context and performance of routine production work. The simulation exercises were distributed by the Mine Safety and Health Administration's National Mine Health and Safety Academy near Beckley, WV. The present study focused on those organizations that ordered the exercises from the Academy over a 2-year period (1995-96). Researchers assessed how the materials were used and trainer perceptions of the impact of these materials on annual mine health and safety training . A total of 147 organizations ordered the exercises over the 2-year period. Survey responses were obtained from 52 of these organizations. Sixty percent of the respondents rated the exercises as more useful than traditional instructional materials, 40% as equally useful, and 0% as less useful. Most trainers (79%) felt that the exercises help them to make better use of workers’ knowledge and experience during training. Many (71%)also reported that the simulations helped to improve the effectiveness of their instruction and promoted a problem-solving approach to their training. Fifty of the fifty-two respondents reported that they would like to have new simulations developed. A large majority showed a proactive interest in helping to develop and field test new exercises. Ninety-four percent of the trainers judged the exercises as a good value; 92% planned to order more simulations in the future. Based on this study, recommendations are offered for the continuation and expansion of simulation exercises as one method for occupational health and safety training.

Jan 1, 2001

By Oliver Bowles, J. E. Crawshow

A line of cordeau detonating fuse was placed in hole No. 2, no electric detonators being used in the hole. After 12 or 13 cases of 40 per cent nitro starch powder had been poured into the hole in loose form, it was found that a space of only 17 ft. remained for stemming. It was decided that space for an additional case of powder might be obtained by tamping the charge. The tamping was done with a heavy plunger, about 3 or 3 inches in diameter and 10 inches long, made of lead with an iron core with an iron eye in the top to which a 3/4 inch rope was attached, and weighing between 30 and 40 pounds. This weight was intended for use in sinking explosive in wet holes, and not for tamping. It is estimated that the tamping had continued at least 10 The quarry superintendent had gone a considerable distance for a box of powder, returned, and reached a point about 10 feet from the hole, minutes.

May 1, 1920

Create two air splits along the longwall face to isolate the shearer-generated dust to the immediate face area, maintaining a cleaner split of air in the workers' walkway.

Jan 1, 1994

By Murray Weintraub

The Bureau of Mines investigated the aerodynamic factors that control the functioning of the blowcase devices used in pneumatic processes for dispersing solids. Alumina powder of 8-micron mass-mean diameter was placed in 0.75- inch-diameter by 10-inch-long cylinders} and a blowcase technique was employed. It was determined that dimensions and gas rates for discharging the powder from the cylinder by a stream of gas may be calculated by assuming a fluidization mechanism and extrapolating residues to a desired finite quantity or to zero at the terminal velocity. The state of agglomeration of a powder at discharge may be determined from measurements of the velocity required for zero residue.

Jan 1, 1967

By Edward D. Thimons

A remote-actuated stench gas fire-warning system has been designed and tested by the Bureau of Mines. This system makes use of the hard-wire network for the mine's phone pager system, thus greatly reducing the system cost. By locating stench gas canisters with remote-actuation release capabilities near working sections, the fire-warning time can be greatly reduced. In a test of the system in a Missouri lead mine, the time required to warn miners of a fire at two working faces was reduced from about 20min with the conventional system to less than 4 min with the remote-actuated system.

Jan 1, 1984

By Thomas P. Meloy

"The presence of respirable quartz-bearing mineral par-ticles has been well documented in many coal mines, and the Mine Safety and Health Administration regulations address the quartz content of mine dusts. Unfortunately, the correlation between the quantity of respirable quartz-bearing mineral particles and the pathogenicity of the dust is not strong. Work is currently underway by the National Institute for Occupational Safety and Health/U.S. Bureau of Mines and work is being included in the Respirable Dust Center Program by Dr. Seehra to determine the surface availability of quartz in mixed composition mine dusts. However, this paper propose a possible source of surface quartz or a spe¬cial region in the coal that may contribute to the pathogenicity of selected particles in the respirable dust.Assumed in this model is the hypothesis that either the cleat surface is coated with quartz or some cytotoxic sub-stance that in the body is capable of destroying macrophage and thus inducing a fibrotic response (1) that during the frag¬mentation a reasonable proportion of the respirable size coal particles contain some of the original cleat surface and that these particles have the same order of in vivo cytotoxicity as do the quartz particles. It may be that these cleat surfaced respirable size particles are only contributory to the overall pathogenicity of the coal dust, nevertheless, there are enough of these particles to to considered as a potential source of the cytotoxic dust particles.This paper demonstrates that if the cleat surfaces are mineralized with quartz or have a pathogenic coating, then in many mines there will be enough respirable coal dust particles containing some cleat surface to cause a fibrotic reaction. To understand why some of the dust particles contain as part of their surface some of the cleat surface, consider what happens when a beer bottle is broken. While there are a large number of beer bottle fragments, many of the fragments, particularly the larger fragment sizes, will have as a fraction of their surface part of the original beer bottle surface. The model and mathematics of this problem have been worked out by Meloy.(2-4)In the homogeneous IAC model, (2-5) a fragment or par-ticle resulting from comminution is equally likely to occur anywhere in the material being broken. Therefore the probability of a particle of size x having part of the cleat surface in it, p(x), is proportional to x. Thus:"

Mar 1, 1989

By H. G. Lucas

A feeder screw supplied at constant pressure by a hopper-orifice arrangement was developed for feeding solids in size ranges up to several hundred micrometers at constant flow rates. Performance of the feeder was evaluated by measuring the flow rates obtained with 3-to 7-micrometer coal ash, 70 percent through 200-mesh coal, and minus 325-plus 400-mesh coal ash. Constant feed rates within a few percent of set values were achieved for half-hour periods for the larger particles and for 5-minute periods for the finer particles. Suggestions are given for feedstock preparation and feeder operation for optimum performance.

Jan 1, 1974

By R. V. Ramani, V. T. Burgos, J. A. McClay

The data for Test I1 describes an underground bituminous coal mine operating in a 72 inch seam, with an estimated production rate of 4,257,000 tons per year. The system includes 15 continuous mining sections, conveyor belt haulage, and a rail network for supply and personnel transportation. The following section includes the input data sequence, annual cost report, and cash flow analysis "report for this data set.

Jan 1, 1975

By R. O. Pynnonen

Tunnel-driving is recognized as a hazardous occupation; adequate support of roof and sides for preventing accidents from falling material is usually one of the most important safety problems. Where extraordinary conditions of sand and water are found, this problem becomes even more difficult. Tunneling at the Tioga No.2 mine was stopped when a 22-foot bed of water-saturated, fine gray sand was encountered. The tunnel, designed to house an ore-conveyor belt, was being driven from both ends. Driving was extremely difficult at both the upper and lower faces when the sand horizon was reached. A distance of 178 feet remained between the faces. Heavy pressures deformed the steel-supporting rings at the upper face, and there was an inrush of mud and sand at the lower face.

Jan 1, 1958

By James E. Hill

The Bureau of Mines has been carrying on an extensive diamond- drilling program during the past 7 years on deposits of strategic and critical minerals . Often the project reports and the drill-hole logs describe the findings only in terms of the mineral being sought at the time . Then , too , results may not always be interpreted alike by several mining engineers , and the cores therefore provide a permanent tangible record to complement the project reports . The cores from projects in the eastern divisions are being stored at the Mount Weather Testing Adit . Core from a representative hole ( or skeletonized sections from several holes , if these are more representative ) is selected at each project and shipped to Mount Weather for permanent storage . At the Testing Adit an underground room was prepared and storage racks were installed . Wooden core trays designed to accommodate cores of various sizes were purchased .

Apr 1, 1947