Search Documents

By V. Castranova, L. Wu, K. Van Dyke, J. Gutierrez, V. Vallayathan

Since it has been demonstrated that silica caused phagocytic cells to activate lipoxygenase metabolism of unsaturated fatty acids we thought selective inhibition of this metabolic pathway might be helpful in treatment of silicosis. It is known that lipoxygenase metabolism plays a role in the pathogenesis of a variety of inflammatory and hypersensitivity conditions. Further, it is believed that the alveolar phagocytic cells which engulf silica begin the inflammatory cycle which produces the metabolic products, cytokines and growth factors which causes fibrosis in the lung. There have been indications that drugs which inhibit lipoxygenase can inhibit fibrosis from other causes. Previously, we developed a method which detects the activity of lipoxygenase metabolism by measuring free radical oxidation via light production or chemiluminescence (CL). We decided to apply this method to phagocytic cells that would be found in the lung in the presence of silica with and without newly developed inhibitors of the lipoxygenase reaction. We used drugs which inhibit lipoxygenase directly including AA861 (TAKEDA), A63162 (Abbott), and an inhibitor that scavenges free radicals produced from the lipoxygenase reaction, nordihydroguairetic acid. In addition we used an indirect inhibitor, tetrandrine. We found drug inhibition of silica activated CL from alveolar macrophages, neutrophils and human leukemia (HL-60) cells differentiated with DMSO. Nordihydroguairetic acid 2x10-5M produced almost complete inhibition in all three cell types. In human leukemia cells (HL-60) A63162 and tetrandrine were equally inhibitory at 42% while in human neutrophils A63162 and tetrandrine were less active 22 and 10% respectively. In macrophages A63162 and AA861 were less than 50% inhibitory to cellular CL at 2xl0-5M. Direct assay of tetrandrine (2x10-5M) with sodium arachidonate and soybean lipoxygenase reveals no inhibition. All antilipoxygenase drugs regardless of mechanism were inhibitory to cellular chemiluminescence from all three types of phagocytic cells. These drugs alone or in mixtures could prove useful in treatment of silicosis.

Jan 1, 1991

By John S. Anderson

The need for fuels and minerals in this country is estimated to double, triple, or even quadruple by the end of the present century. Even assuming more recycling of scrap metals and some priority allocation of energy, as has been done, for instance in war time, the projected increase in the nation's population and ever-increasing wants of that population will require vastly more minerals than are now being produced. Since mineral ores are being mined at lower grades, and since all minerals, including fuels, are having to be mined from deeper deposits, the amount of surface land to be disturbed will, inevitably, be increased. We cannot depend on foreign sources to supply all the extra requirements, since the non-U.S. population is increasing, in most cases, faster than our own. Furthermore, starting from a lower base, their mineral needs may accelerate more rapidly than ours. Restrictions on exports may be applied in foreign countries, if it appears that remaining reserves are not sufficient to fill the national needs. In vice; of the opposition which the mineral industry is receiving, as has been well described at these sessions and elsewhere, what can we, as mineral producers, anticipate as regards our ability to continue to operate, to sway nothing of expanding production? Although not minimizing the problems involved, it seems obvious that, except under emergency conditions, the country cannot tolerate a reduction in the available

Jan 1, 1971

By John P. Norton

Microcystaline silica has been mined in Illinois from the Clear Creek formation since the turn of the century, especially in the area around Tamms in Alexander County, in the southernmost part of the state. Production of this silica, consumed mainly by the abrasives and coatings industries but also sought after for many filler/extender uses, has grown with the economy with several new applications overshadowing traditional markets in recent years. Such an important commodity was given the early attention of the Illinois State Geological Survey and a very complete report was issued in 1953 (Report of Investigations No. 166), authored by J. E. Lamar. The mining and processing of the silica ore has changed very little since the first reported production in 1906, although emphasis has been placed on the production of the finer sized grades to meet newer market requirements. Industrial Mineral Notes 40, published by the Illinois State Geological Survey in June 1970, describes a method by which a less than 1-micron fraction could be commercially produced from the readily available finest commercial grade presently being marketed (99% minus 10 microns). The finer grades exhibit to a lesser degree the reinforcement, high flatting efficiency, thickening and dry brightness properties associated with the synthetically produced silicas. It is expected that the extremely fine grades of microcrystaline silica will become accepted in the markets that now use a combination of precipitated silica and less expensive extender/filler minerals such as kaolin or calcium carbonate.

Jan 1, 1976

By John E. Urosek, Mark L. Mott, Gary E. Smith

One function of Mine Safety and Health Administration (MSHA), Pittsburgh Health Technology Center's Ventilation Division is to provide assistance to MSHA enforcement and industry personnel for maintaining adequate fresh air to all areas of an underground mine. In fulfilling this objective, total mine venti1ation pressure-air quantity distribution on investigations are conducted to measure the air pressures and quantities necessary to describe and analyze the existing ventilation systems. Various ventilation parameters are calculated from these measured pressures and quantities. Some of these parameters are: pressure drop in intake and return airways, air leakage, percentages of air reaching active sections, average regulator drops, and fan pressures. The purpose of this paper is to present and compare values of ventilation parameters calculated from investigations at twenty underground coal mines.

Jan 1, 1987

By A. Dadgar, R. H. Sergent

Changes in the ore types available and increased environmental concern have created a demand for an alternative technology to cyanide for the extraction of gold from ore. Great Lakes Chemical Corporation (Great Lakes) believes that halogen chemistry, in particular bromine chemistry, is the best available alternative to cyanide for gold extraction. Great Lakes is a Fortune 500 chemical company with sales of approximately one billion dollars per year. Great Lakes extracts elemental bromine from naturally occurring brines in Southern Arkansas. Great Lakes has developed a family of proprietary bromine compounds to aid in the extraction of gold. In addition to proprietary bromine compounds for gold extraction, Great Lakes has developed a method of recycling bromide ion in the leach circuit. Various recovery methods, including ion exchange and solvent , extraction are currently being studied.

Jan 1, 1990

Mines in the Lake Macquarie region of New South Wales, Australia, are faced with the dilemma of having to introduce longwall mining techniques at a time when increasingly large areas of the surface are being used for urban development. Increasing pressures on safety, costs and productivity performance dictate that longwall mining is the method for the future. Construction of surface structures is controlled by a statutory body known as the Mine Subsidence Board (MSB). All surface structures have to be designed to MSB criteria. All mining plans involving secondary excavation also have to be submitted to the MSB for approval. The Board acts as risk assessor in evaluating acceptable levels of surface subsidence vs. the value of the coal resource. Surface repairs are paid for by a levy on all coal producers.

Jan 1, 1995

By J. A. Cole

Santa Fe Pacific Gold's Lone Tree mine is located in Humboldt County, NV, 45 km (28 miles) east of Winnemucca. The mine currently operates a 1.74-Mt/a (1.92-million stpy) run-of-mine heap-leach operation and a 2.27-kt/d (2500 stpd) refractory gold¬ore-processing plant. Most of the mill-grade ore reserves are refractory, mainly due to pyrite and arsenopyrite encapsulation of the gold. The autoclave pressure-oxidation circuit was commissioned in February 1994 to process the refractory ore. Mineralogy unique to the Lone Tree deposit allowed for the design of a partial-oxidation process. It takes advantage of the heterogeneous nature of the pyrite morphology. Partial oxidation has resulted in an autoclave plant that is able to achieve low operating-unit costs (Figs. 1 and 2).

Jan 1, 1995

By William J. Kohan

Milling has traditionally been considered more art than science. In the last 10 years, significant improvements in process equipment have been made and we are finally taking significant steps toward approaching grinding as a science. Two machines have been at the center of this development. These are the roll press and the high efficiency separator. The former can be considered as a new technology or adaptation of existing i.e. roller mill. The latter is clearly an improvement of existing technology. Other machines have been introduced to a lesser degree and later. Among these are the CKP and Horomill. The purpose of this paper is to provide an over- view of the currently available modifications for operating systems and options for new milling circuits with some comments on their application and history.

Jan 1, 1997

By Dennis V. D’Andrea, Peter G. Chamberlain, James J. Olson, William C. Larson

Blasts designed for in situ copper leaching must produce adequate fragmentation and permeability for successful leaching. Copper recovery depends to a large extent on the particle size distribution created by the blast, the permeability in the blast- fractured zone, and the ability to maintain solution flow with a minimum amount of channeling. This paper presents the results of Bureau of Mines experiments where core drilling was used before and after blasting to establish the degree of fragmentation. Data are presented from tests at the Sierrita mine of Duval Corp., and also from tests at the Emerald Isle mine of El Paso Mining and Milling Co. Copper recovery is predicted from fragment size distribution data using a computer model. Data from several blasts are used to show how predicted copper recovery is related to powder factor.

Jan 1, 1977

By T. A. Jones

The Kelsey Centrifugal Jig is an enhanced gravity concentrator capable of separating fine minerals and/or minerals with relatively small differences in specific gravity. Since the first commercial installation at the Renison Bell tin mine in Australia, development and improvement in hardware has continued, including the introduction of the high-capacity J1800model Kelsey Jig. The Kelsey Centrifugal Jig is widely applicable to fine mineral recovery duties, with key application areas including mineral sands, tin, gold and nickel. Other areas of application include: iron ore, base metals, chromite, PGMs, soil remediation and scheelite. The latest developments on the Kelsey Jig are discussed together with a review of recent installations involving: • Fine gold / sulphide recovery from leach tailings • Magnesium mineral removal from nickel sulphide concentrates • High-grade zircon recovery from plant tailings

Jan 1, 2004

By Ahmet Gursoy

Maryland, will be the widest vehicular tunnel ever built by the trench tube method. Careful coordination and planning were required to meet the tight and fast design and construction schedules. During the preliminary design, traditional design drawings were bypassed in favor of 25 preliminary design reports representing major work breakdown structures (tasks). For each task, alternative design solutions were examined and analyzed by means of trade-off studies on the basis of engineering, constructibility, and economic considerations, thus providing an overall conceptual value engineering approach for the entire project. So far, total value engineering proposed by the contractor for Contract I I (largest contract of the project at $245 million) is less than 1.5 percent of the contract value. This is an important indication of the success of the design phase planning.

Jan 1, 1983

By P. G. Semple, K. W. Major, R. M. Nendick

As free milling oxide gold ore reserves are depleted, more mining companies are having to evaluate the available alternatives for treating refractory deposits. The selection of a treatment process can be very difficult; and, despite the claims of their respective proponents, there is no one process that will continuously prove superior. Selection of the optimum process for an individual deposit is contingent on the size of the deposit, the grade of the deposit and the refractory nature of the ore. Since extensive metallurgical test programs are usually required to determine the optimum extraction process, an inappropriate initial selection may prove costly and time consuming. This paper discusses the steps involved in evaluating a refractory ore in order to expedite the evaluation of the required process through the feasibility study stage.

Jan 1, 1990

By Yuusaku Tominaga, Sukumar Bandopadhyay

A power-series trend curve of elapsed time was estimated by using time series data of measured concentrations of carbon monoxide in the Taiheiyo coal mine, Hokkaido, Japan. The difference between the moving average concentration data and the estimated data from the trend curve showed linear correlation when plotted on a normal probability paper and a correlation coefficient value of 0.99. It is concluded that the estimate of carbon monoxide concentration using moving average values of concentrations compares very well with the results obtained from the trend curve within the three-sigma (standard deviation) range of the distribution. Thus, it is believed the results can be used to monitor and detect abnormal ventilation conditions in a ventilation network such as the occurrence of spontaneous combustion at an early stage.

Jan 1, 2002

By Patricia T. Foley

An analysis of the demand for copper shows a widely varying pattern of end use. For example, copper tube is the most popular material for hot water supply in the US and northern Europe, but galvanized steel is used in Japan and plastics are used in developing countries. In addition to such peculiarities of end use, the demand for copper varies among countries depending on the stage of industrialization and the extent that the copper processing industries are developed. Brazil, with its abundant supplies of bauxite and hydroelectric power, uses aluminun in place of copper wherever possible. South Korea, with its export oriented economy and its advanced custom smelting and fabricating industries, favors copper. Understanding the details of demand in different countries enhances statistical derived forecasts and illustrates potential new markets.

Jan 1, 1986

By M. Ericsson

The extractive industries consist of five major sectors: - Mining equipment and services - Dimensional stone - Industrial minerals - Aggregates - Metal mining These industries produce some finished goods but mostly semi-finished products as they feed into other industrial sectors: Basic metals, fabricated metals, construction, chemicals, dyes and pigments, inorganic chemicals, fertilizers, rubber and plastics and non-metallic mineral products. These are the major down-stream industries in this study. Taken together with the extractive industries they form the mineral resource based cluster. The mineral resource based cluster is a substantial part of the Finnish economy: It employs 211 000 persons, 39% of the number of employees in industry. The cluster?s exports account for 20% of industry exports. Value added is 34% of total value added in industry. Investments reach 35% of total industry investments.

Jan 1, 2003

By Oliver Gutsche

High-pressure roll mill comminution of heterogeneous multicomponent feeds was simulated with artificial limestone-quartzite mixtures using a piston-die press. The influence of heterogeneous interactions between components of the mixture on grinding path, energy utilization and energy split have been examined. Primary fractures are governed by differential fracture strength and attrition resistance of the components at heterogeneous contacts; subsequent secondary and tertiary fracture events are governed by coarse-fine interactions in the particle-bed. The weaker component is preferentially ground out of the feed size fraction and concentrates in the fines. Energy split among the components in the mixture is a function of their relative fracture strengths. It doubles for limestone and decreases by a factor of 5 for quartzite over the entire range of the mixing ratio.

Jan 1, 1995

By Welland L. Ott, Hans J. Rumland

The Falconbridge Dominicana laboratory receives samples from all parts of the operation. Ore, metal and oil samples are taken by operating departments, gas and water samples by the laboratory staff. Physical sample preparation is essentially standard and produces comminuted samples for wet-chemical analysis and X-ray fluorescence analysis (XRF). T he main operating sections of the laboratory are described indicating in each case the type of instrumentation and method used, sample types analysed and comments on problems experienced. Emphasis is given to the sample preparation and X-ray sections especially with regard to the difficulties caused by our heterogenous ore material, calibration of the instrument and operational malfunctions. General problems related to our remote location and the tropical climate are discussed. Limited statistics on instrument availability, and stability, accuracy, precision, etc., are given.

Jan 1, 1979

By Wallace W. Wilson

It scarcely 1s possible to read a new issue of any of the principal mining trade journals without noting some mention of a major new overseas mining venture with which one or more domestic companies are involved. These projects seem to follow a fairly consistant pattern; most are large open pit mines, with relatively low grade ore bodies but huge reserves; the total price tag will be in nine significant figures and around half or more of the total cost will be for infrastructure. West1 noted that nearly $7 billion is being invested annually for new mining projects and the expansion of existing mining ventures, in the free world. He anticipates that by the year 1975 such investments would reach the $10-11 billion annual figure, and that in the five year period 1972-76 total capital requirements can be expected to aggregate around $45 billion. The proportion of this total investment which will be financed in some manner is difficult to estimate because of the variety of available financing arrangements. West estimated that around 75% of the total capital would come from internally generated funds, with the balance from external sources. Conceivably a substantially higher percentage could be attributable to external financing, especially it the trend of recent mineral development in Canada and Australia is any criterion, and of course, including local sales of equity as a part of the package.

Jan 1, 1973

By R. H. King

The US coal industry has been using continuous room-and-pillar mining (CRPM) machines for more than 30 years for longwall development. This equipment has also been used for production mining in areas that are not appropriate for longwall mining. From 1977 to 1987, the portion of annual US production mined by continuous miner (CM) sections grew slightly from 65% to 70%. Over this time, mine operators and manufacturers have made some advances to attain the full production potential of this method. This is evidenced by the fact that average tons per eight hour shift for continuous miners in the US grew from 180 t (200 st) in 1977 to 431 t (475 st) in 1987. The authors (1990) reported that the increase in productivity was due to several factors: • a drop in prices; • a more mature workforce; • union stability and incentive programs; •procedural improvements; and •technological advances. The authors estimated that about one-third of the increased production came from the first three and other unaccounted for factors and one-third each for the last two. Even though improvements were considerable, continuous miner capacity is much higher than 431 t/shift (475 st per shift). For example, the machinery is capable of mining more than 9 t (10 st) per machine for the 6.5 available hours per shift or 3.5 kt (3900 st). However, this has never been attained on development. The averages of most mines are less than 900 t/shift

Jan 1, 1991

By 000-000-604

HISTORIACAL INTRODUCTION Mineral processing has three principle branches, to quote Taggart, "Ore Dressing, which comprises the methods of separation of solids in inorganic crude by means which do not affect substantial chemical change; Extractive Metallurgy, which utilizes chemical reactions for separations of constituents from solids in inorganic crude; and, Fuel Technology, which employs both physical and chemical methods for separating and rearrangement of liquid gaseous and solid components in crude oil and natural gas, tar sands, shale oil, or coal." The scope of this handbook covers the first two classifications, that is, "ore dressing" and "extractive metallurgy," which have been combined in one term: "mineral processing." For a brief history of the development of mineral processing, one could well refer to the Introduction, Sec. I of the Handbook of Mineral Dressing by Taggart, Froth Flotation, Principles of Mineral Dressing by Gaudin, and the original Richard's Ore Dressing, volume No. 1, first published in 1903-1905. In these references and the references given in them a coverage of the history of "ore dressing" can be found and studied at the reader's leisure. For the history of extractive metallurgy as well as ore dressing, the bibliography in General References, taken from a History of Ex¬tractive Metallurgy by F. Habashi, will give a good background for those who are interested in more detail on the history of metallurgy in general. Mineral processing covers a very wide field as is illustrated by the topics discussed in Part II of this handbook and dates back to the early history of man which started with the production and use of native minerals such as gold, silver, copper, mercury, and meteoric iron which were washed or picked from deposits on the surface of the earth and worked because of their malleability. Later, melting was discovered and then it was possible to cast objects of these metals, excluding mercury. The discovery of a method for reducing the metal¬lic oxide probably was developed from melting fragments of oxides or roasted sulfides with charcoal, so that the native metal could be produced in simple blast furnaces such as are used today in rural parts of Spain, China, and elsewhere. Eventually, it was learned that iron could be readily worked when hot, which resulted in its replacing bronze for tools, weapons, and cutlery. Carbon dating and correlation with the Brittle Cone pine has

Jan 1, 1985